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Flashcards in NSAIDS Deck (16)
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1
Q

injury to tissue specific PGs

A

injury>phospholipids, Phospholipase A2 converts to Arachidonic acid. COX converts to PGH2 which is converted to tissue specific PG

2
Q

COX1 vs COX2

A

housekeeping; inflammatory

3
Q

celebrex (celecoxib)

A

COX2 specific inhibitor. Still affects kidney but not GI tract and not platelets

4
Q

allodynia

A

touch causes pain (sunburn) (periphery)

5
Q

hyperalgesia

A

pain is amplified (poke sunburn with pin) (central)

6
Q

Are NSAIDs analgesics

A

They are anti-hyperalgesics. Cut hurts just as much but afterward not as much

7
Q

how do you reduce ulcers from NSAIDS?

A

give a PPI or MISOPROSTOL (increases mucus formation. Causes diarrhea

8
Q

how do NSAIDS affect kidney? which COXs?

A

COX1 &2. BP elevation in pts treated for htn and necrosis in pts with reduced renal flow

9
Q

what cox do platelets have? haw does it make?

A

COX1. forms thromboxane A2

10
Q

how does aspirin have such a long effect on platelets

A

no cell nucleus means no more COX so its inhibition is irreversible.

11
Q

Reye’s syndrom

A

dont give ASA to kids with viral illness. you get seizures, coma, death

12
Q

Acetaminophen actions

A

not anti-inflammatory. Decent antipyretic and analgesic

13
Q

toxicity of acetaminophen

A

liver

14
Q

go back over NSAID names

A

motrin, naprosyn, indocin, diclofenac (voltaren), nabumetone (relafen), ketorolac (toradol), mobic (meloxicam)

15
Q

ketorolac

A

IV

16
Q

NSAIDS are ideal for

A

perioperative use (no ileus but causes bleeding), incident pain