Obstetrics - 1M Flashcards
(100 cards)
Which of the following statements on the
pharmacokinetic properties of drugs used in
pregnancy is/are correct?
A. Fat-soluble drugs are distributed more
widely and tend to linger in the body
because they are slowly released from the
storage sites.
B. The absorption of an intramuscularly
administered drug is highly effective.
C. Since the placenta is a semi-permeable
membrane and a site of metabolism, all drugs
that pass through the placenta will be nontoxic to the fetus.
D. All of the above
A. Fat-soluble drugs are distributed more
widely and tend to linger in the body
because they are slowly released from the
storage sites
To be considered a teratogen, a candidate substance
or process should:
A. Result in a characteristic set of
malformation, including a selectivity for
certain target organs
B. Exert its effects at any stage of fetal
development
C. Show a dose-independent incidence
D. All of the above
A. Result in a characteristic set of
malformation, including a selectivity for
certain target organs
Fetal anoxia secondary to the use of
vasoconstrictors like prostaglandin and ergot is an
example of which teratogenic mechanism?
A. Direct drug actions on the process of
differentiation
B. Deficiency of a critical substance
C. Indirect effects on fetal tissue
D. Continued exposure to a teratogen may
produce cumulative effects or may affect
several organs going through varying stages
of development
C. Indirect effects on fetal tissue
The most crucial period of organogenesis and
therefore the time of greatest theoretical risk for
congenital malformations is
A. Pre-embryonic phase
B. Embryonic phase
C. Fetal phase
B. Embryonic phase
Thalidomide may affect the development of arms
and legs after only a brief exposure during
A. 3rd-8th weeks of gestation
B. 3rd-7th weeks of gestation
C. 4th-8th weeks of gestation
D. 4th-7th weeks of gestation
D. 4th-7th weeks of gestation
The principle of rational prescribing in pregnancy
will include the following:
A. Drugs that have teratogenic effects in animal
studies always present with risk of
malformation in humans when given in
clinical doses
B. Drugs that have been proven effective
should be continued and experimenting
new drugs should be avoided
C. Since pregnant women are orphan patients, it
is safe to assume that absence of data in
clinical studies means no teratogenic risk to
the fetus
D. All of the above
B. Drugs that have been proven effective
should be continued and experimenting
new drugs should be avoided
The following statements on physiologic and
relative pharmacokinetic changes of pregnancy is/are
true:
A. Because of the 50% increase in blood
volume and body water, drug dosage
should be increased in women taking
water-soluble drugs
B. Drug dosage should be increased in drugs
that are highly protein-bound since more free
drug is available for therapeutic effects on
mother and for placental transfer to the fetus
C. The dose of amoxicillin for a pregnant patient
with a UTI should be doubled because
amoxicillin is excreted unchanged in urine
D. All of the above
A. Because of the 50% increase in blood
volume and body water, drug dosage
should be increased in women taking
water-soluble drugs
Choose the best anticoagulant for a 32-year-old
primigravid on her 18th week AOG with lower limb
deep vein thrombosis
A. Heparin
B. Warfarin
C. Aspirin
D. Streptokinase
A. Heparin
A 25-year-old G1P0 on her 24th week AOG was
diagnosed to have UTI. Drug of choice for this patient
will include:
A. Tetracycline
B. Penicillin
C. Quinolones
D. All of the above
B. Penicillin
Which of the following is a correct combination of
a drug and its associated congenital anomaly?
A. Warfarin: DiSala Syndrome
B. Phenytoin: Cleft lip palate
C. Valproic acid: Ebstein anomaly
D. ACEI: Microcephaly
A. Warfarin: DiSala Syndrome
True statements about epilepsy in pregnancy
A. The incidence of congenital malformation
secondary to monotherapy or use of single
drugs in treatment of epilepsy is 0.5-1%
B. The dose of anti-epileptic drugs postpartum
is the same dose given during pregnancy
C. The first line of drug in the treatment of
epilepsy in pregnancy is valproic acid
D. All of the above
A. The incidence of congenital malformation
secondary to monotherapy or use of single
drugs in treatment of epilepsy is 0.5-1%
Which of the following associations between first
trimester antibiotic exposure and the given birth defect
is true?
A. Aminoglycoside may cause ototoxicity
B. Chloramphenicol may cause ashen-gray skin
coloration
C. Tetracycline may cause deciduous teeth
discoloration
D. Nitrofuratoin may cause cleft lip
Nitrofuratoin may cause cleft lip
Which of the following herbal remedies is
associated with increased risk of bleeding by
inhibiting COX?
A. Garlic
B. Ginger
C. Ginseng
D. Ginkgo biloba
D. Ginkgo biloba
(Disputed: Ginger is COX inhibitor according to
Williams)
Which of the following fetal concerns made the
FDA reclassify magnesium sulfate from category A to
category D?
A. Cleft lip & palate
B. Cardiac defects
C. Bone demineralization
D. Facial deformities
C. Bone demineralization
Which of the following is potential fetal
consequence of nitrofurantoin if given at or near term
A. Staining of deciduous teeth
B. Hemolytic anemia
C. Fetal arrhythmia
D. Neural tube defects
B. Hemolytic anemia
Fern formation of dried cervical mucus is due to the effect of which hormone? A. Progesterone B. Human placental lactogen C. Estrogen D. Prolactin
C. Estrogen
Softening of the uterine is most resulting in its
compressibility on bimanual examination is called?
A. Goodell’s sign
B. ?
C. Hegar’s sign
D. Chadwick’s sign
C. Hegar’s sign
A 24-year-old came in for vaginal spotting. Her
LMP was Oct. 4, which of the following clinical
findings will be most suggestive of pregnancy?
A. Previous menses every 28-30 days
B. Breast pain
C. Increase vaginal discharge
D. Bluish discoloration of the vagina
A. Previous menses every 28-30 days
A 28-year-old primigravid came in for her first
prenatal check-up. Her last LMP was Aug. 17, 2020.
She started vomiting 1 week ago. Her ultrasound
findings last Nov. 2 showed a live intrauterine
pregnancy compatible with 7 weeks intrauterine
gestation. What will be her AOG today?
A. 13 weeks
B. 9 weeks
C. 10 weeks
D. 8 weeks
B. 9 weeks
A 24-year-old consulted for vaginal spotting. Her
LMP was Oct. 12, 2020. Pregnancy test was positive.
Pelvic ultrasound showed a well-formed intrauterine
gestational sac, no fetus seen. Which of the following
is the most likely diagnosis?
A. Abortion
B. Failure of implantation
C. Ectopic pregnancy
D. 5 weeks gestation
D. 5 weeks gestation
A woman who has had 2 full term deliveries, 1
preterm delivery, 1 abortion, and 2 living children
would have this OB score:
A. G4P3 (2112)
B. G4P2 (2112)
C. G3P3 (2112)
D. G3P2 (2112
A. G4P3 (2112)
Which of the following vaccines is recommended during pregnancy? A. DPT B. HPV C. Hep B D. MMR
A. DPT
A 38-year-old G6P5 had her prenatal check-up on
her 28th week of gestation showed a fundic height of
24 cm. What are the possibilities?
A. Normal pregnancy
B. Intrauterine growth restriction
C. Oligohydramnios
D. Genetic disorder
B. Intrauterine growth restriction
What information aside from gestational age is
considered especially important during prenatal visits?
A. Maternal heart rate
B. Accurate maternal BP
C. Activity
D. Occupation
B. Accurate maternal BP