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MODHIII - Unit 3 > Obstructive Lung Disease > Flashcards

Flashcards in Obstructive Lung Disease Deck (47)
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1

Type of airflow in small airways

laminar

2

Why is flow turbulent in large airways and laminar in small airways

- high flow rate in large airways causes turbulent flow, and low flow rate in small airways allow for laminar flow

3

Large airway disease process

- greater changes in pressure are required to change airflow
- insensitive to most changes in diameter or pressure
- clinically significant changes in airflow require very large changes in driving pressure or airway diameter

4

Large airway diseases

- obstructive apnea
- aspiration of foreign body
- airway tumors

5

Small airway disease process

- changes in flow are linearly related to changes in pressure but exponentially related to changes in airway radius
- small changes in diameter produce substantial changes in flow

6

Small airway diseases

- asthma
- COPD

7

Differences in total cross sectional area b/w large and small airways

- cross sectional area increases exponentially from large to small airways
- therefore there is a lot less resistance in the smaller airways

8

Significance of larder cross sectional area of small airways

- young adults who smoke have substantial airway inflammation but have few, if any, symptoms of COPD until the disease has progressed for decades

9

Dynamic changes in airway diameter during respiratory cycle

- expansion during inhalation
- compression during exhalation

10

Significance of airway expansion during inhalation and compression during exhalation

- will hear wheezes during exhalation before you will during inhalation

11

How loss of elastic tissue in COPD effects airflow resistance

- emphysema patient airways will collapse during exhalation, b/c damage to walls have made them weak

12

Clinical relevance of wheezing during different points of respiratory cycle

- progression of disease follow wheezing
- wheezing during end of exhalation is early disease followed by wheezing throughout exhalation and finally with late disease patient will have wheezing during inhalation

13

Spirometry parameters and values

- FVC: volume exhaled during very forceful and prolonged exhalation
- FEV1: volume exhaled in the first second-normal is 80%
- FEV1/FVC: percentage of vital capacity exhaled in 1 second-normal is 80%, obstructive diseases

14

Flow-volume loop: explain steady exhalation slope

- steady flow out of lung b/c you can't use expiratory muscles past a certain point or they will collapse airways

15

Flow-volume loop: obstructive disease

- airways collapse easier so the exhalation slope will be steeper and won't reach as high

16

Large airway obstruction: location

- oropharynx, trachea, main bronchi

17

Large airway obstruction diseases

- tumors of trachea
- benign fibrous structures and scarring
- functional disorder: sleep apnea
- aspiration of foreign bodies

18

Clinical features of large airway obstruction

- dyspnea: not changed by medical management (ineffective steroids)
- stridor: MONOphonic wheeze
- KEY feature includes presence during inhalation only or both inhalation and exhalation; not altered or improved with coughing****

19

Asthma statistics

- 1/12 people have asthma (2009), increased from 1/14 (2001)
- 1 in 2 people with asthma have at least one attack every year
- $56 billion medical costs, about $3,300 per person
- 3,404 deaths in 2010
- slightly more prevalent in women for all ages

20

Asthma pathophysiology

1. airway epithelial damage
2. maintenance of inflammatory cell & cytokine environment in airways including lymphocytes, eosinophils, neutrophils, plasma/mast cells
3. airway remodeling

21

Airway remodeling in asthma

- increased thickness of basement membranes
- increased mass of airway smooth muscle
- goblet cell metaplasia with mucus hypersecretion
- increased airway angiogenesis and lymphangiogenesis

22

How is asthma different from COPD

asthma is predominantly an AIRWAY disease and does not lead to lung parenchyma disease

23

Cell most commonly associated with asthma

- Type-2 helper cell cytokine mediated eosinophilic airway inflammation

24

Phenotypes of asthma

1. early onset allergic disease w/ TH2 response
2. TH2 response but not allergic syndrome
3. exercise induced
4. obesity related
5. neutrophil dominated

25

Clinical syndrome of asthma

- chronic disease involving inflammation of pulmonary airways
- hyperresponsiveness resulting in lower respiratory obstruction
- REVERSIBLE

26

Development of asthma

- chronic airflow results from airway remodeling
- acute hyperresponsiveness: bronchoconstriction, airway edema, mucus plug formation
- symptoms

27

Symptoms of asthma

- coughing, particularly at night
- wheezing
- chest tightness
- dyspnea w/ exertion and shortness of breath at rest

28

Physical exam in asthma patients

- wheezing
- prolonged exhalation
- hyperresonance to percussion
- diminished air entry breath sounds
- accessory muscle use

29

Asthma staging

- normal,mild intermittent, mild persistent: FEV1>80%
- moderate persistent: FEV1 60-80%
- severe persistent: FEV1

30

Cornerstone of asthma treatment

- control of underlying inflammation for ALL patients with persistent symptoms