Onco/Hema Flashcards Preview

Pedia > Onco/Hema > Flashcards

Flashcards in Onco/Hema Deck (35)
Loading flashcards...
0

Phases of treatment of ALL

Remission induction - 4 weeks
Consolidation phase - 14-28 weeks
Maintenance phase - 2-3 years

1

BM findings in ALL

> 25% of BM cells as a homogenous population of lymphoblasts

2

Remission in ALL

< 5% blasts in BM and return of platelet and neutrophil count to near normal levels

3

Sites of relapse for ALL

Bone marrow
CNS, testes - sanctuary sites

4

Staging classification for Lymphomas

Ann Arbor Staging Claasification

5

B symptoms important in staging lymphoma

Weight loss > 10% of TBW over 3 months
Unexplained high fever
Drenching night sweats

6

Reed sternberg cells

Hodgkin's lymphoma

7

Which with more extra nodal involvement - Hodgkins or Non-Hodgkins

Non-Hodgkins

8

Tx for Hodgkins

COPAD
Cyclophosphamide
Vincristine
Prednisone
Doxorubicin

9

MC subtype of NHL

Burkitt lymphoma (40%)

10

Wilms tumor - crosses the midline or not?

No. Does not cross the midline

Wan side lang

11

Painless abdominal pain with flank mass that does not cross the midline in a 3 year old

Wilms tumor

12

Median age of diagnosis of Neuroblastoma

2 years old

13

Gene associated with Neuroblastoma

N-myc

14

Opsoclonus/ myoclonus

Neuroblastoma

15

Dancing eyes, dancing feet

Neuroblastoma

16

Dx tests for Neuroblastoma

Abdominal CT scan
24- hr urine VMA and HVA (?)

17

Most common soft tissue sarcoma in children

Rhabdomyosarcoma

18

Worst histologic subtype of rhabdomyosarcoma

Alveolar

19

Vaginal grape-like mass - type of rhabdomyosarcoma

Sarcoma botryoides

20

Highest risk period for development of osteosarcoma

Adolescent growth spurt

21

Deep bone pain causing nighttime awakening

Osteosarcoma

22

X-ray finding in osteosarcoma

Sunburst pattern
Due to mineralization and formation of periosteal spicules in the surrounding tissue

23

Moth eaten lytic lesion on X-ray

Ewing sarcoma

24

Origin of Ewing sarcoma

Neural crest

25

Ewing sarcoma arising from the chest wall

Askin tumors

26

MC chromosomal aberration of Ewing sarcoma

t(11;22) translocation

27

Classic X-ray finding of Ewing sarcoma

Onion skinning or moth eaten appearance

28

Location of osteosarcoma in bone

Metaphyses of long bones

29

Location of Ewing sarcoma on bone

Diaphysis of long bones