Onco/Hema Flashcards
BM findings in ALL
> 25% of BM cells as a homogenous population of lymphoblasts
Phases of treatment of ALL
Remission induction - 4 weeks
Consolidation phase - 14-28 weeks
Maintenance phase - 2-3 years
Remission in ALL
< 5% blasts in BM and return of platelet and neutrophil count to near normal levels
Sites of relapse for ALL
Bone marrow
CNS, testes - sanctuary sites
Staging classification for Lymphomas
Ann Arbor Staging Claasification
B symptoms important in staging lymphoma
Weight loss > 10% of TBW over 3 months
Unexplained high fever
Drenching night sweats
Reed sternberg cells
Hodgkin’s lymphoma
Which with more extra nodal involvement - Hodgkins or Non-Hodgkins
Non-Hodgkins
Tx for Hodgkins
COPAD Cyclophosphamide Vincristine Prednisone Doxorubicin
MC subtype of NHL
Burkitt lymphoma (40%)
Wilms tumor - crosses the midline or not?
No. Does not cross the midline
Wan side lang
Painless abdominal pain with flank mass that does not cross the midline in a 3 year old
Wilms tumor
Median age of diagnosis of Neuroblastoma
2 years old
Gene associated with Neuroblastoma
N-myc
Opsoclonus/ myoclonus
Neuroblastoma
Dancing eyes, dancing feet
Neuroblastoma
Dx tests for Neuroblastoma
Abdominal CT scan
24- hr urine VMA and HVA (?)
Most common soft tissue sarcoma in children
Rhabdomyosarcoma
Worst histologic subtype of rhabdomyosarcoma
Alveolar
Vaginal grape-like mass - type of rhabdomyosarcoma
Sarcoma botryoides
Highest risk period for development of osteosarcoma
Adolescent growth spurt
Deep bone pain causing nighttime awakening
Osteosarcoma
X-ray finding in osteosarcoma
Sunburst pattern
Due to mineralization and formation of periosteal spicules in the surrounding tissue
Moth eaten lytic lesion on X-ray
Ewing sarcoma
