Oncology Flashcards

1
Q

What is required of a pre-cancer treatment assessment to make someone dentally fit?

A

Identify all existing oral disease and potential risk of disease

Remove infection and potential infection

Prepare pt for possible side fx

Develop plan for maintaining oral hygiene

Plan post treatment prosthetic oral rehab

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2
Q

What treatment should I provide during pre cancer treatment?

A

Detailed OHI

Fluoride delivery

Diet advice that coincides with dietician - focus on comfort during treatment

PMPR to stabilise perio and consider chlorhexadine

Restore all carious teeth

Remove any trauma - sharp edges of dentures for e.g.

Impressions to construct fluoride trays or soft splints

Denture hygiene

XLA teeth at least 10 days before cancer treatment begins

Consider antibiotic prophylaxis if low neutrophils - liaise with physician

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3
Q

What are some possible side FX of cancer treatment?

A

Mucositis - due to high turnover of oral epithelium

HSV reactivation due to immunosuppression (aciclovir)

Candida infection - opportunistic

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4
Q

What is the gold standard narrow spectrum antibiotic used in dentistry now?

A

Phenoxymethylpenicillin

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5
Q

If a patient was to develop a dental infection mid chemotherapy, what concerns would there be?

A

Platelet count - bleeding risk

Further Infection

Get a full blood count and coagulation screening

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6
Q

What is mucositis?

How manage?

A

Chemotherapy / radiotherapy targets oral epithelium

Severe pain which can inhibit eating and OH measures

Treat with:

gelclair
Aloe Vera
Soluble aspirin
Morphine or opioids as analgesic
Rinse with saline water
Lidocaine mouthwash prior to eating

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7
Q

Why might candida develop in an oncology patient?

How treat?

A

Candida is opportunistic, cancer patients are immuncompromised

Chlorhexadine

Miconazole topical

Fluconazole systemic

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8
Q

How might ulceration occur to oncology patient? How treat?

A

Sensitive oral mucosa damaged by sharp or rubbing area

Treat with soft splint from impressions

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9
Q

Why might HSV reappear in oncology patient? How manage?

A

Immunosuppression patient allows re activation of latent virus

Has a prodromal period of pain prior to ulceration

Needs treated immediately with systemic antivirals such as aciclovir

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10
Q

Why might a cancer patient have xerostomia?

How treat?

A

Cancer treatment reduces salivary flor 50-60% in first week, leading to dry mouth due to damage to salivary glands

Saliva becomes more viscous and also more acidic

Treat with fluoride supplementation due to increased caries risk

Also treat with oral gel or lubricants on soft tissues e.g. Vaseline

Pilocarpine HCL can enhance salivary production if some functioning gland remains - 5mg 3 x daily

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11
Q

Why might an oncology patient present with gross caries?

A

Radiation-induced caries which is rapidly developing

Coupled with xerostomia and high protein high calorie diet for cancer patients

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12
Q

What is ORN? How does it occur?

A

Osteoradionecrosis

It is exposed necrotising bone exposed by radiation therapy, resulting in need for XLA of teeth in radiotherapy field

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13
Q

When might a cancer patient be discharged to a GDP from hospital?

A

Side fx settled

Carious food intake stopped

Good OH reestablished

Fluoride is tolerated comfortably

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14
Q

How is someone made dentally fit?

A

Detailed oral hygiene

Topical fluoride application

GC tooth mousse

Diet advice with dietician

PMPR to stabilise perio

Consider chlorhexadine mouthwash

Definitive restorations

Removal of any trauma
- sharp edges

Removal of any source of infection / poor prognosis teeth
- no less than 10 days before starting tx

Impressions for fluoride trays

AB prophylaxis - low neutrophils?

Smoking and alcohol advice

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15
Q

Dentist role during cancer therapy?

A

Hygienist support

Oral and denture hygiene

Chlorhexadine MW if brushing not possible

Diet advice

Fluoride delivery all the time
- topical
- trays etc

Relief of symptoms
- xerostomia
- mucositis
- soft splints to prevent trauma

Emergency dental tx
- liaise with cancer team if pt has infection

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16
Q

Aetiology mucositis?

A

1-2 weeks after tx starts and lasts around 6 weeks after treatment is complete

17
Q

How manage mucositis?

A

Neutral, supersaturated calcium phosphate mouth rinse (Caphosol)

Sodium hyaluronate gel (gelclair)

Mucoadhesive oral rinse (mugard)

Benzydamine mouthwash (difflam)

Lidocaine ointment / mouth rinse 2%

Remove sharp edges / poorly fitting dentures

Soft splints

Ice (oral cooling)

18
Q

How can mucositis be assessed?

A

Voice

Swallowing

Lips

Tongue

Saliva

Mucous membrane

19
Q

What viral issues may arise during cancer tx?

A

Reactivation of HSV

  • prodromal period!!!!
  • pain prior to ulceration and must recieve urgent treatment with systemic antivirals
20
Q

Cancer tx effects on saliva?

A

50-60% reduction in salivary flow
- further 20% in next 5-6 weeks

Saliva becomes more viscous and acidic!
- damage to dentition

Recovery over years or not at all

21
Q

Why is saliva reduced in cancer pts? How tx?

A

Ionising radiation to the salivary tissue in the radiotherapy field

  • fluoride supplements due to caries risk
  • oral gel / petroleum jelly to coat soft tissues
  • pilocarpine
  • Sugar free chewing gum / regular small sips
  • biotene saliva replacements
22
Q

How can trismus occur post cancer tx?

A

Post surgery inflammation

Fibrosis of tissue due to tx

(Tumour recurrence causing limited opening must be excluded)

23
Q

Characteristics of post cancer tx trismus?

Tx?

A

Following radiotherapy:
- occur rapidly in first 9 months
- tends to be progressive and may be irreversible

Physical therapy
- passive and active stretching
- therabite
- trismus screw
- stacked tongue depressors

24
Q

What is an ORN diagnosis?

A

Area of exposed bone
- at least 3 months
- in radiotherapy field
- not due to tumour recurrenc

25
Q

How prevent ORN?

A
  • remove teeth of doubtful prognosis in field
  • heavy prevention! OHI, fluoride etc
  • extractions 10 days prior to radiotherapy (at least)

Liaise with oncologist

26
Q

% of ORN after extraction in irradiated pts?

A

7%

4% with HBOT

6% with antibiotics

27
Q

Who is high risk of ORN?

A

Dose exceeded 60Gy

Dose fraction is large with high number of fractions

Local trauma
- extractions (esp mandible)
- ill fitting prosthesis
- uncontrolled perio

Immunocompromised

Malnourished

28
Q

Suggested tx of ORN?

A

Surgical debridement of necrotic tissue

Antibiotics - co-amoxiclav / penicillin (prophylaxis)

Pentoxyfylline and vitamin E (treatment)

Hyperbaric oxygen

OH!

29
Q

How stage ORN?

A

0 = mucosal defects only

1 = dentoalveolar bone necrosis

2 = positive findings above IAN canal with denuded bone intra orally

3 = clinically exposed radionecrotic bone, skin fistulas and infection, possible pathological fracture

30
Q

How can reconstruction and maintenance be carried out for those with ORN?

A

Implants!
- failure less likely when dose <45Gy
- requires lots of maintenance

Dentures
- avoided where possible
- hygiene essential
- excellent fit essential