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Oncology Flashcards

(45 cards)

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1
Q

Nitrosoureas cause what toxicity?

A

Neurotoxicity

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2
Q

Nitrosourea examples

A

lomustine, carmustine

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3
Q

Platinum-based chemo meds cause what toxicities?

A

nephrotoxicity, peripheral neuropathy, vomiting

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4
Q

Platinum-based med examples

A

Carboplatin, cisplatin

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5
Q

MTX, 5-FU, and capcitabine cause what toxicity?

A

Mucositis

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6
Q

Bleomycin, busulfan, carmustine, lomustine cause what toxicity?

A

Pulmonary fibrosis

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7
Q

Anthracyclines cause what toxicity?

A

Cardiotoxicity

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8
Q

Anthracycline examples

A

Doxorubicin, daunorubicin

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9
Q

Immunotherapy for cancer causes what toxicity?

A

Autoimmune syndromes

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10
Q

Examples of immunotherapy for cancer

A

ipilimumab, atezolizumab, pembrolizumab

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11
Q

Ifosfamide and cyclophosphamide cause what toxicity?

A

Hemorrhagic cystitis

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12
Q

Vinca alkaloids cause what toxicity?

A

peripheral neuropathy

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13
Q

Examples of vinca alkaloids

A

vincristine, vinblastine, vinorelbine

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14
Q

Taxanes cause what toxicity?

A

peripheral neuropathy

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15
Q

Examples of taxanes

A

paclitaxel, docetaxel

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16
Q

What chemo meds cause bone marrow suppression?

A

Most of them, EXCEPT bleomycin, pegaspargase, vincristine

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17
Q

Irinotecan causes what toxicity?

A

DIARRHEA

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18
Q

Chemo-adjunctive treatment: what to give with cisplatin

A

amifostine and hydration

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19
Q

What do amifostine and hydration do to help with cisplatin treatment?

Study These Flashcards
A

Prevent neurotoxicity

20
Q

Chemo-adjunctive treatment: what to give with doxorubicin

21
Q

Purpose of dexarzozane in doxorubicin treatment

Study These Flashcards
A

Prevent cardiotoxicity

22
Q

Chemo-adjunctive treatment: what to give with 5-FU

Study These Flashcards
A

leucovorin, levoleucovorin

23
Q

Purpose of leucovorin/levoleucovorin with 5-FU

Study These Flashcards
A

enhance efficacy

24
Q

Antidote for 5-FU

Study These Flashcards
A

uridine triacetate- give within 96 hours

25
Chemo-adjunctive treatment: what to give with ifosfamide
mesna
26
Purpose of mesna with ifosfamide treatment
prevent hemorrhagic cystitis
27
Antidote for capecitabine
uridine triacetate
28
Chemo-adjunctive treatment: what to give with irinotecan
atropine, loperamide
29
Purpose of atropine and loperamide with irinotecan
Atropine for acute diarrheal episodes loperamide for delayed diarrheal episodes
30
Chemo-adjunctive treatment: what to give with MTX
leucovorin, levoleucovorin
31
Purpose of leucovorin/levoleucovorin with MTX
protect the cells from toxicity after high-dose MTX
32
MTX antidote
glucarpidase, give within 48-60 hours
33
Extravasation treatment: anthracyclines
COLD compresses, give dexrazozane/dimethyl sulfoxide
34
Extravasation treatment: vinca alkaloids
WARM compresses, give hyaluronidase
35
Max doses: bleomycin
cumulative lifetime dose of 400 units
36
Max doses: doxorubicin
cumulative lifetime dose of 450-550mg/m2
37
Max doses: cisplatin
100mg/m2/cycle
38
Max doses: vincristine
single dose capped at 2mg
39
What route should you NOT give vincristine
Intrathecally (duh)
40
TLS management
Aggressive IV hydration electrolyte correction as needed urate lowering treatment: allopurinol, rasburicase
41
Hypercalcemia of malignancy treatment
hydration with NS Calcitonin IV bisphosphonates: Zometa (zoledronic acid) Denosumab (Xgeva)
42
CINV treatment: high emetic risk
NK1-RA+5HT3 RA+olanzapine+dexamethasone
43
CINV treatment: moderate emetic risk
NK1-RA+5HT3 RA+ dexamethasone
44
CINV treatment: low emetic risk
One drug (as long as it's not Emend): dexamethasone, prochlorperazine, metoclopramide
45
CINV treatment: minimal emetic risk
no routine prophylaxis needed

NAPLEX (18 decks)

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