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NAPLEX > Renal Disease > Flashcards

Renal Disease Flashcards

(47 cards)

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1
Q

Where do SGLT2s work?

A

proximal tubule

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2
Q

Where do loops work?

A

ascending limb of the Loop of Henle

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3
Q

Where do thiazides work?

A

distal convoluted tubule

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4
Q

Where do potassium-sparing diuretics work?

A

distal convoluted tubule and collecting duct

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5
Q

Drugs that cause kidney disease

A

AGs
Amphotericin B
Cisplatin
Cyclosporine
Loops
NSAIDs
Polymixins
Contrast dye
Tacrolimus
Vanco

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6
Q

Stage 1 CKD

A

GFR ≥90 with kidney damage

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7
Q

Stage 2 CKD

A

GFR 60-89 with kidney damage

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8
Q

Stage 3a CKD

A

GFR 45-59

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9
Q

Stage 3b CKD

A

GFR 30-44

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10
Q

Stage 4 CKD

A

GFR 15-29

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11
Q

Stage 5 CKD

A

<15 or dialysis dependent

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12
Q

Albuminuria category A1

A

ACR <30

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13
Q

Albuminuria category A2

A

ACR 30-300

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14
Q

Albuminuria category A3

A

ACR >300

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15
Q

First-line treatment for CKD and HTN

A

ACEis/ARBs

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16
Q

Treatment for CKD and diabetes

A

SGLT2i

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17
Q

Drugs that need a decreased dose or increased dosing interval in CKD: anti-infectives

A

AGs
Beta-lactam ABX (except nafcillin, oxacillin, CTX)
Fluconazole
Quinolones (except moxifloxacin)
Vanco

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18
Q

Drugs that need a decreased dose or increased dosing interval in CKD: cardiovascular drugs

A

Enoxaparin
DOACs (Xarelto, Eliquis, Pradaxa)

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19
Q

Drugs that need a decreased dose or increased dosing interval in CKD: GI drugs

Study These Flashcards
A

Famotidine, ranitidine
Metoclopramide

20
Q

Drugs that need a decreased dose or increased dosing interval in CKD: other

Study These Flashcards
A

lithium, bisphosphonates

21
Q

Drugs that are CI’ed in CKD: <60ml/min

22
Q

Drugs that are CI’ed in CKD: <50ml/min

Study These Flashcards
A

TDF-containing products (Complera, Delstrigo, Stribild, Symfi), IV voriconazole

23
Q

Exception about Stribild

Study These Flashcards
A

If currently being treated with it, it is CI’ed in CrCl <50. If starting treatment, can’t be <70ml/min

24
Q

Drugs that are CI’ed in CKD: <30ml/min

Study These Flashcards
A

TAF-containing products (Descovy, Biktarvy, Genvoya, Odefsey, Symtuza), NSAIDs, Pradaxa, Xarelto

25
Drugs that are CI'ed in CKD: eGFR <30
metformin
26
Exception about metformin
If already on metformin, eGFR can't fall less than 30 If about to start metformin, eGFR has to be >45
27
CI'ed in CKD
meperidine, SGLT2is
28
Phosphate binders: aluminum based
aluminum hydroxide
29
Aluminum hydroxide side effect
"Dialysis dementia"
30
Phosphate binders: calcium-based
Calcium acetate Calcium carbonate
31
Calcium-based phosphate binders side effects
Constipation, hypercalcemia
32
Phosphate binders: aluminum free and calcium free
Sucroferric oxyhydroxide, ferric citrate, lanthanum carbonate
33
Sevelamer side effects
N/V/D, can lower total cholesterol and LDL by 15-30%
34
All phosphate binders must be taken with what?
FOOD
35
Vitamin D analogs for hyperparathyroidism
calcitriol, calcifediol, doxercalciferol, paricalcitol
36
Calcimimetics for hyperparathyroidism
cinacalcet, etelcalcetide
37
Anemia of CKD treatment options
Procrit/Epogen/Retacrit, Aranesp needs sufficient iron stores for it to be effective
38
Drugs that raise potassium levels
ACEis Aldosterone receptor antagonists Aliskiren ARBs Canagliflozin Drosperinone-containing COCs Potassium-containing IV fluids, potassium supplements high doses of Bactrim Transplant drugs (tacrolimus, cyclosporine, everolimus)
39
Hyperkalemia treatment: stabilizes the heart
calcium glutinate, calcium chloride
40
Hyperkalemia treatment: moves potassium intracellularly
regular insulin with dextrose, sodium bicarb, albuterol
41
Hyperkalemia treatment: what removes potassium from the body
furosemide SPS patiromer sodium zirconium cyclosilicate hemodialysis
42
Warnings for SPS
can bind other PO meds, GI necrosis
43
Patiromer warnings
hypomagnesemia, binds to PO drugs
44
Patiromer side effects
Constipation, nausea, diarrhea
45
Caveat about patriomer
Slow onset of action
46
Sodium zirconium cyclosilicate warning
Can bind other drugs
47
Best thing about Lokelma
Has the fastest onset of action

NAPLEX (18 decks)

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