Oncology drugs Flashcards Preview

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Flashcards in Oncology drugs Deck (11)
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1
Q

What are some side effects of tamoxifen?

A

hot flushes, weight gain, thromboembolism, endometrial hyperplasia

2
Q

how do chemotherapeutic agents work?

A

usually target a part of the cell cycle to prevent cell division and proliferation

3
Q

what are the endocrine drug of choice for breast cancer in post menopausal women?

A

aromatase inhibitors

4
Q

what are some bladder consequences of cyclophosphamide?

A

haemorrhagic cystitis

5
Q

what should also be prescribed with cyclophosphamide?

A

PCP prophylaxis- trimethoprim and sulfamethoxole (bactrim) unless contraindicated due to allergy

6
Q

what is the main mode of action of cyclophosphamide?

A

cytotoxic effects on lymphocytes

7
Q

what are the main SE of cytotoxic antineoplastic drugs?

A

alopecia, bone marrow suppression, damage to mucous membranes, delayed healing, teratogenicity

8
Q

what type of drug is methotrexate? how does it work?

A

Folic acid antagonist. Inhibits DNA synthesis and cell replication by competitively inhibiting the conversion of folic acid to folinic acid

9
Q

what are some SE of adriamycin?

A

cardiac toxicity

10
Q

what are some SE of oncovan?

A

peripheral neuropathy

11
Q

what is a SE of bleomycin?

A

pulmonary inflammation