Oogenesis and Spermatogenesis Flashcards

(46 cards)

1
Q

Where does Oogenesis begin

A

In utero

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2
Q

When is oogenesis completed

A

Fertilisation

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3
Q

When does oogenesis cease

A

At the menopause

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4
Q

Describe the production of oocytes

A

cyclical

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5
Q

What is the earliest recognisable terminal cell

A

The primordial germ cell

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6
Q

What is a primordial germ cell capable of

A

Mitosis

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7
Q

Where do primordial germ cells migrate to and when

A

The genital ridge by week 6 of embryo development

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8
Q

What is one of the two products in the first stage of meiosis

A

The first polar body

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9
Q

What does the presence of two polar bodies signify

A

Sperm entry and the completion of the 2nd meiotic division

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10
Q

What is the difference between the divisions in females to males

A

Unequal division in females

Equal division in males

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11
Q

When is there the largest number of germ cells in the female

A

8 months of development

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12
Q

Why is there a massive death of germ cells at birth

A

Unknown

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13
Q

Roughly how many germ cells will be ovulated

A

400-500

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14
Q

Roughly how many germ cells are females born with

A

2million

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15
Q

How long does the ovarian cycle last

A

28 days

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16
Q

What are the 2 phases of the ovarian cycle

A

Follicular and Luteal

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17
Q

What happens in the follicular phase of the ovarian cycle

A

Maturation of egg, ready for ovulation at mid-cycle

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18
Q

What signals end of follicular phase

A

Ovulation

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19
Q

What happens in the Luteal phase of the ovarian cycle

A

Development of the corpus luteum

Induces preparation of reproductive tract for pregnancy (if fertilisation occurs)

20
Q

What is the primary follicle

A

The single layer of granolas cells that surrounds the primary oocyte

21
Q

What do a lot of primary follicles do before ovulation

A

Undergo atresia or death

22
Q

What do follicular cells left behind after ovulation undergo

A

Luteinisation - transformation to the corpus luteum

23
Q

What does the corpus luteum secrete

24
Q

What happens to the corpus luteum after ovulation

A

It grows for 8-9 days

25
What happens to the corpus luteum if no fertilisation has occurred
It will survive no longer than 14 days after ovulation
26
What does the degeneration of the corpus luteum signal
The start of a new follicular phase
27
What happens to the corpus luteum is fertilisation has occurred
Corpus luteum persists and produces increasing quantities of progesterone and oestrogen until after pregnancy
28
Where is GnRH secreted from
The hypothalamus
29
What two hormones does the anterior pituitary secrete that is important in females
FSH and LH
30
What does FSH do?
Stimulates development of follicles
31
What does LH do
Stimulates follicule maturation, ovulation and development of the corpus luteum
32
Where do both LH and FSH act
The ovary
33
What do FSH and LH stimulate
The secretion of estradiol and ovulation
34
What do the theca cells produce
Androgen
35
What is androgen converted to and by what
Oestradiol and by the granulosa
36
What does estradiol do
Thickens endometrium / thins cervical mucus
37
What does oestrogen do to FSH
Suppresses the production
38
What does the granolas in the dominant follicle express
LH receptor
39
What do high levels of oestrogen at mid cycle cause
hypothalamus to release GnRH
40
What happens to the levels of LH and FSH during ovulation
The levels fall
41
How can we detect ovulation
Measure LH levels from a dipstick In clinic using US Measuring temperature
42
What forms the corpus luteum
Remaining granulosa
43
What does the corpus luteum degenerate to form
The corpus albicans
44
If pregnancy occurs, what does the developing embryo produce
hCG (chorionic gonadotrophin)
45
What does hCG do?
Maintains the corpus luteum
46
The placenta takes over the role of what at around 6 weeks
The corpus luteum