Opioids

Question 1

Morphine Dose

Answer 1

Intra: 1- 10 mg
PostOp: 2- 10 mg

Question 2

Fentanyl Dose + Trade Name

Answer 2

Sublimaze

1 - 3 mcg/kg

Question 3

Sufentanil Dose

Answer 3

Intra: 0.3 - 1 mcg/kg
Infusion: 0.5 - 1 mcg/kg/hr

Question 4

Remifentanil Dose + Trade Name

Answer 4

Ultiva

DOSED on IDEAL BW

Loading 0.5 - 1 mcg/kg over 1 min
Infusion: 0.125 - 0.375 mcg/kg/min

Question 5

Meperidine Dose + Trade Name

Answer 5

Demerol

Used for Post-op shivering

12.5 mg

Question 6

Hydromorphone Dose + Trade Name

Answer 6

Dilaudid

Intra: 1- 4 mg
PostOp: 1.5 - 4 mg

Question 7

Naloxone Dose + Trade Name

Answer 7

Narcan

40 - 80 mcg

Question 8

Morphine Onset

Answer 8

10 - 20 min

Question 9

Morphine Duration

Answer 9

4 - 5 hr

Question 10

Fentanyl Onset

Answer 10

30 - 60 sec

Question 11

Sufentanil Onset

Answer 11

30 - 60 sec

Question 12

Fentanyl Duration

Answer 12

1 - 1.5 hr

Question 13

Sufentanil Duration

Answer 13

1 - 1.5 hr

Question 14

Remifentanil Onset

Answer 14

30 - 60 sec

Question 15

Remifentanil Duration

Answer 15

6 - 8 min

Question 16

Meperidine Onset

Answer 16

5 - 15 min

Question 17

Meperidine Duration

Answer 17

2 - 4 hr

Question 18

Hydromorphone Onset

Answer 18

5 - 15 min

Question 19

Hydromorphone Duration

Answer 19

2 - 4 hr

Question 20

Naloxone Onset

Answer 20

1 - 5 min

Question 21

Naloxone Duration

Answer 21

30 min

Question 22

Mu1

Answer 22

Analgesia
Euphoria
Miosis
Bradycardia
Hypothermia
Urinary Retention

Question 23

Mu2

Answer 23

Analgesia
Resp Depression
Physical Dependence
Constipation

Question 24

Kappa

Answer 24

Analgesia
Dysphoria
Sedation
Miosis
Diuresis

Question 25

Delta

Answer 25

Analgesia Resp Depression Dependence Urinary Retention

Question 26

Opioid MOA

Answer 26

Activate mu, kappa, and delta receptors Presynaptic inhibition of acetylcholine, dopamine, norepinephrine, Substance P Decreased calcium channel activity Increased potassium conductance Hyperpolarize cell

Question 27

Morphine Pharmacodynamics

Answer 27

Primarily mu 1 & mu 2 Active metabolite Morphine -6- glucuronide Poor lipid solubility Highly protein bound Clearance: Renal

Question 28

Fentanyl Pharmacodynamics

Answer 28

Mu 1 & Mu 2 Lipid Soluble Non ionized form high in physiologic pH Active metabolite: norfentanyl Metabolism: Hepatic P450s Clearance: Renal

Question 29

Sufentanil Pharmacodynamics

Answer 29

Mu 1 & Mu 2 Lipid soluble Metabolism: Hepatic Clearance: Renal & Fecal

Question 30

Remifentanil Pharmacodynamics

Answer 30

Mu 1 & Mu 2 lipid soluble Metabolism: Plasma esterases Clearance: Renal

Question 31

Meperidine Pharmacodynamics

Answer 31

mu1, mu2, kappa Active metabolite: normerperidine Metabolism: Hepatic Clearance: Renal

Question 32

Hydromorphone Pharmacodynamics

Answer 32

Mu 1 & Mu 2 Water soluble Metabolism: Hepatic

Question 33

Naloxone Pharmacodynamics

Answer 33

Nonselective for Mu, Delta, Kappa Opioid antagonist Metabolism: Hepatic

Question 34

Morphine E 1/2 time

Answer 34

2-3 hours

Question 35

Naloxone E 1/2 time

Answer 35

1 - 1.5 hours

Question 36

Hydromorphone E 1/2 time

Answer 36

3 - 5 hours

Question 37

Remifentanil E 1/2 time

Answer 37

6 min

Question 38

Sufentanil E 1/2 time

Answer 38

2-5 hours

Question 39

Fentanyl E 1/2 time

Answer 39

3-7 hours