Opioids Flashcards Preview

Pharmacology > Opioids > Flashcards

Flashcards in Opioids Deck (11):
1

MOA

Cellular level - activate receptors.
Relieve dull, deep, visceral pain

2

Receptor locations

PAG
Limbic system
Thalamus and hypothalamus
Medulla oblongata

3

Receptor types

Mu1 - analgesic, euphoria
Mu2- brain + GIT = respiratory depression and constipation
Kappa - analgesic, sedation
Delta - analgesic

4

Pure agonists

Morphine
Pethidine
Codeine
Tramadol
Heroine
Methadone

5

Partial agonists

Pentazocine
Buprenorphine

6

Antagonists

Naloxone
Naltrexone

7

Pethidine

Analgesic in fetus - cross placenta
Do not constrict pupils, release histamine or suppress a cough

8

Pentazocine

Increase pulmonary arterial pressure and is not recommended

9

Side effects of opioids

GIT - vomit and nausea
Dependence

10

Side effects of Tramadol

Seizures
Psychiatric
Hypotension

11

Naloxone uses

Apnoeic infant
Opioid poisoning