Oral Environment Flashcards
what are the two forms of mucins?
anchored form MG2
soluble form MG1
what is a negative of the anchored form of mucins?
Bacteria bind to it and modify side chains it to help adhesion
what is a positive of the anchored form of mucins?
Invitro peptides that are antibacterial
Antifungal peptides
what is a positive of the soluble form of mucins?
Is flushed out along with any bacteria associated with it -> antibacterial
what are proline rich peptides (PRPs) bound to?
hydroxyapatite -> newly formed pellicle
negative of proline rich peptides (PRPs)
Bacterial adhesion with carboxy terminal
positive of proline rich peptides (PRPs)
Acidic type are degraded and have antibacterial properties
More PRPs in caries free patients
what is the function of statherin?
calcium posphate control
- regulate pH and remineralisation
what are the functions of glucans?
adhesion
carbohydrate storage
negative of glucans?
Glucantransferase binding site for bacteria
positive of pellicle-attached immunoglobulins
Can mark pathogens for destruction
Underpins the idea to immunise against S.mutans
negative of pellicle-attached ummunoglobulins
Streptococci can degrade antibodies for nutrients
positive of cystatins
Degrade bacterial proteins that cause damage impairing bacterial pathogenicity e.g. cysteine proteases
positive of histatins
Promotes wound healing
Histatin 5 is antifungal (anti-candida)
Antibacterial especially red complex
positive of lysozymes
Break down membranes leading to the destruction of bacteria
