Ortho Flashcards
(100 cards)
Tx cascade for OA
1st line = topical analgesia i.e. topical NSAID (diclofenac)
2nd line = paracetamol + local analgesia
3rd line = NSAID + paracetamol + local analgesia (+PPI)
4th line = Opioid (e.g. oxycodone) + paracetamol + NSAID + local analgesia
Adjunct = IA Corticosteroid injection
Surgical options = arthrodesis, THR/TKR
what is mnemonic for OA on x-ray
L – loss of joint space
O – osteophytes
S – sclerosis
S - subchondral cysts
what are the Ix results for RA (antibodies)
Auto-Ab – Rheumatoid factor, Anti-CCP
Bloods – CRP raised
how does RA present
swelling, morning stiffness, pain, deformity, loss of function, nodules
affects small joints and c-spine
what might be seen in hands in RA
Boutonniere deformity
Ulnar deviation
Swan-Neck deformity
Mx of RA
DMARD monotherapy +/-bridging prednisolone
= Methotrexate
TNF inhibitors
- infliximab
side effects of methotrexate
myelosuppression – monitor FBC + LFTs
pneumonitis
what are the seronegative/HLA B27 arthritis
AS
Psoriatic arthritis
Reactive arthritis
Inflammatory Bowel Disease arthritis
how does AS present
Chronic inflammation – spine and sacroiliac joints fusion of joints
Young males
Symptoms – pain, stiffness, hip/knee arthritis
Ix of AS
X-Ray
Key Buzzwords = ‘sacroiliitis’ ‘bamboo spine’, ’squaring of lumbar vertebrae’
Mx of AS
- important
1st line = NSAIDs, physio, EXERCISE [gets much better w/ exercise]
2nd line = Anti-TNF therapy = etanercept/adalumumab
DMARDS only useful if peripheral joint disease
Adjunct = IA corticosteroids
how does psoriatic arthritis present
30% skin psoriasis
Asymmetrical, oligoarthritis, sacroiliitis, spondylitis, dactylitis and enthesitis
nail changes: pitting, onycholysis, arthritis DIP joints
Ix of psoriatic arthritis
x-ray
- pencil-in-cup appearance
what are common causative organisms for reactive arthritis
GI - campylobacter, shigella, salmonella, yersinia
GU - chlamydia, gonorrhoea
Sx of reactive arthritis
urethritis, uveitis, arthritis
“can’t see, can’t pee, can’t climb a tree”
Mx of reactive arthritis
Rx underlying infection, symptomatic relief, +/- DMARDS
what is gout and what causes it
Urate crystals in joints – hyperuricaemia
Renal underexcretion or excessive intake of alcohol, red meat, seafood
how does gout present
Classic site – 1st MTP joint, ‘podagra’
CF – intensely painful, hot, swollen joint, tophi
Ix for gout
1st line = joint aspiration
- Synovial fluid with needle shaped, negative birefringence
Mx of gout
Acute = NSAIDS, colchicine, intra-articular corticosteroid
Long term = allopurinol
what can allopurinol interact with and what can it cause
Azathioprine
- can cause pancytopenia
what is pseudogout
1 - Calcium pyrophosphate crystals – causing acute arthritis
2 - Chondrocalcinosis - deposits in cartilage/soft tissue, but no inflammation
Ix of pseudogout
joint aspirate
= Synovial fluid w/ positively birefringent crystals
Mx of pseudogout
NSAIDS, corticosteroids, +/- colchicine
hydroxychloroquinine