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SBB Review > Other Blood Group Systems > Flashcards

Other Blood Group Systems Flashcards

(65 cards)

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1
Q

GPI linked glycoprotein on acetylcholinesterase

A

Yt

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2
Q

Yt antigens

A

Yta- high prevalence in all pop.
Ytb- 8% except in israeli’s where it can be up to 26%

No known null phenotype

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3
Q

Yta antigen w/ enzyme or DTT treatment

A

Destroyed

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4
Q

Yt antibodies

A

Usually IgG

No HDFN

anti-yta may cause HTR

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5
Q

Yta with trypsin and a-chymotrypsin

A

Trypsin-not effected

A-chymptrypsin- destroyed

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6
Q

XG blood group antigens

A

Xga and CD99

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7
Q

XG gene locations

A

XG : Xp22.32 tip of the short arm- not inactivated by lyonization

CD99 gene is on both X and Y chromosome

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8
Q

Xga prevalence

A

66% males

89% females

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9
Q

Anti-Xga

A

Usually IgG reactivity at IAT

Not considered clinically significant

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10
Q

Xga with ficin

A

Sensitive

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11
Q

Xga with DTT/AET

A

Resistant

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12
Q

Colton antigens

A

Co^a, Co^b, Co3, Co4

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13
Q

High prevalence Colton antigens

A

Co^a, Co3, Co4

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14
Q

Co^b prevalence

A

10%

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15
Q

Colton antigen location

A

Aquaporin-1 (red cell water transporter)

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16
Q

Colton gene location

A

Chromosome 7p14

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17
Q

Colton antibodies

A

usually IgG

Implicated in HDFN and HTRs

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18
Q

Colton antigen with proteolytic enzymes

A

Resistant

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19
Q

Anti-Co3

A

Made by rare Co(a-b-) phenotypes caused by various inactivating mutations

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20
Q

Co4

A

Required for Co^a expression

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21
Q

Gerbrich high prevalence antigens (6)

A

Ge2, Ge3, Ge4, GEPL, GEAT, GETI

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22
Q

Gerbrich low prevalence antigens (5)

A

Wb, Ls^a, An^a, Dh^a, GEIS

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23
Q

Gerbrich antigen locations

A

GPC and GPD- part of a junctional complex of membrane proteins that interact with protein 4.1 and p55 that help link membrane and it’s skeleton for membrane stability

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24
Q

Gerbrich gene location

A

Chromosome 2q14-21

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25
GPC receptor for what parasite/virus
Plasmodium falciparum Influenza A and B
26
Gerbrich null
Ge:-2,-3,-4 Both GPC and GPD absent Cells are eliptocytes
27
Yus phenotype
Ge:-2,3,4 Make anti-Ge2 No depression of Kell/Vel antigens Lack GPD with altered GPC
28
Gerbich phenotype
Ge:-2,-3,4 Make anti-Ge2 and/or -Ge3 Weakened Kell/Vel expression Lack GPD with altered GPC
29
Leach phenotype
Ge:-2,-3,-4 Make antibodies to all Decreased Kell/Vel expression Lack GPC and GPD Elliptocytes
30
Gerbrich antigens with treatment
Trypsin: destroyed Papain: destroys Ge2,4; Ge3 resistant
31
Distinguish anti-Ge2 from anti-Ge3 in absence of rare cells
Use papain treated cells
32
Gerbrich antibodies
Usually IgG but may be IgM Usually not clinically significant but anti-Ge3 has caused mild HTR/HDFN
33
Cromer antigen location
Decay-accelerating factor (CD55)- a complement regulatory glycoprotein
34
Cromer low incidence antigens
Tc^b, Tc^c, and WES^b Other 15 are high frequency
35
Cromer null
Inab phenotype | Make anti-IFC
36
Cromer antigen with cell treatment
Destroyed by a-chymotrypsin Resistant to papain, ficin, and trypsin Weakened by AET/DTT
37
Cromer antigen is a receptor for what parasite
Plasmodium falciparum
38
Cromer antibodies
Usually IgG Not usually considered to be clinically significant Inhibited by serum or concentrated urine of antigen positive individuals
39
Dombrock gene location
Chromosome 12p13
40
Do a/b frequency Whites
Do(a+b-): 18% Do(a+b+): 49% Do(a-b+): 33%
41
Do a/b prevalence African American
Do(a+b-): 11% Do(a+b+): 44% Do(a-b+): 45%
42
Dombrock null phenotype
Gya- Result of various inactivating mutations Make anti-Gya
43
Hy- and Jo(a-)
Uncommon phenotypes Negative or weak expression of dombrock antigens
44
Dombrock antigens on treated cells
Resistant to papain and ficin Sensitive to trypsin, a-chymotrypskn, pronase Sensitive to DTT/AET
45
Dombrock antibodies
Typically IgG Usually weakly reactive Have been implicated in HTRs but no HDFN
46
Indian antigen location
CD44- cell surface receptor for glycosaminoglycan hyaluranan
47
Indian antigen/ prevalence
In^a: low In^b: high INFA, INJA, INRA: high
48
Indian antigens with RBC treatment
Sensitive: papain, ficin, trypsin, a-chymotrypsin. As well as DTT/AET
49
Indian antigen weak expression on
Cord cells | In(Lu)
50
Indian antibodies
Not generally clinically significant Anti-Inb has caused HTR
51
Vel blood group
1 antigen: Vel- high incidence
52
Vel antigen expression
Weak on cord cells Variable expression among individuals
53
Vel effect on treated RBCs
Enhanced by enzymes Variable effect with DTT/AET
54
Anti-Vel
Often a mix of IgM and IgG Readily activated complement Cause of severe HTRs though HDFN is rare
55
Diego antigen location
Band 3, red cell anion exchanger
56
Diego gene location
Chromosome 17q21.31
57
Di^a prevalence
Rare in European and African 5% Asian Up to 50% in n. and s. American indigenous people
58
Di^b prevalence
High prevalence in all populations
59
Diego Dia and Dib antibodies
Usually IgG reactivity at IAT May cause HDFN but no known HTRs
60
Wra/Wrb
Wra: low Wrb: high Expression dependent on GPA presence
61
Anti-Wra
Usually IgG Relatively common Responsible for severe HDFN and HTRs
62
Diego antigen on treated RBCs
Resistant to proteolytic enzymes ficin, trypsin, and papain Antigens on 3rd extracellular loop sensitive to a-chymotrypsin
63
Chido /Rogers antigen location
On fragment of C4d (complement component) that attaches to RBCs from plasma NOT PRODUCED BY RBCS
64
Chido/Rogers antigen on treated RBCs
Destroyed by proteolytic enzymes (papain, ficin)
65
Chido/Rogers antibodies
Generally IgG detected at IAT No known HDFN/HTRs but may cause anaphylactic reactions Inhibited by plasma of Ch/Rg+ individuals

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