Other Drugs

Question 1

What is fomepizole?

Answer 1

Inhibitor of alcohol dehydrogenase - used for ethylene glycol or methanol ingestion

Question 2

What is pralidoxime?

Answer 2

Antidote for cholinergic toxicity (e.g. organophosphates (acetylcholinesterase inhibitor))
Given with atropine to reactive choliesterase

Question 3

Explain salicylate pH shifts

Answer 3

Respiratory alkalosis from direct stimulation of medullary respiration center

Then metabolic acidosis from oxidative phosphorylation cutoff and buildup of lactate, ketoacids

Note tinnitus, fever, tachypnea, nausea, GI disturbance