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Flashcards in Other Exam 1 Questions Deck (16):
1

Which of the following is NOT a potential consequence of acute inflammation
A. Resolution
B. Autoinflammation
C. Scarring
D. Chronic inflammation
E. Abscess formation

B. Autoinflammation

2

A three-year-old male presents with increased susceptibility to infection with Neisseria meningitidis. Which of the following complement components/regulators is he most likely missing?
A. C1
B. C1 inhibitor
C. DAF
D. C4
E. C5

E. C5

3

Identify the PAMP from the list below
A. C5a
B. TGFβ
C. TLR4
D. LPS
E. CD31

D. LPS

4

One of the consequences of TLR ligation is
A. Activation of NFκB
B. Phagocytosis
C. Inhibition of IRFs
D. Caspase-1 activation
E. IL-1 production

A. Activation of NFκB

5

Which of the following is most important for host defense?
A. NADPH oxidase
B. Epithelial barrier function
C. Phagocytosis
D. TNF production
E. Interferon production

B. Epithelial barrier function

6

Natural Killer cell mediated ADCC requires
A. Antibody binding to bacteria
B. Antibody binding to host cell
C. Antibody binding to a virus
D. Antibody that does not bind to a target

B. Antibody binding to host cell

7

The three main effector functions of complement are
A. Opsonization, leukocyte migration, pathogen lysis
B. Phagocytosis, leukocyte migration, pathogen lysis
C. Opsonization, leukocyte activation, pathogen lysis
D. Phagocytosis, leukocyte activation, pathogen lysis

A. Opsonization, leukocyte migration, pathogen lysis

8

Which of the following pathogen surfaces would NOT be amenable to triggering complement activation?
A. A pathogen that is opsonized with IgG
B. A pathogen that is opsonized with IgM
C. A pathogen that is expressing mannose
D. A non-opsonized pathogen
E. All of the above are amenable to complement activation

E. All of the above are amenable to complement activation
?

9

Which of the following enzyme complexes is directly responsible for generation of the most potent complement anaphylatoxin?
A. C1 convertase
B. C3 convertase
C. C5 convertase
D. Membrane attack complex
E. C1 inhibitor

B. C5 convertase. C5a is the most potent complement anaphylatoxin

10

Which of the following cytokines would most likely be the most effective anti-viral therapy?
A. TNF
B. IL1
C. IL6
D. IFNγ
E. IFNα

E. IFN-alpha

11

Which of the following is NOT a cardinal sign of inflammation?
A. Pus
B. Redness
C. Swelling
D. Heat
E. Pain

A. Pus

12

Which of the following inflammatory mediators directly promotes vasodilation and vascular permeability?
A. TNF
B. IL1
C. Histamine
D. C5a
E. Bradykinin

C. Histamine

13

Hageman factor is activated by which of the following?
A. Microbial surfaces
B. Epithelium
C. Endothelium
D. Basement membrane
E. Histamine

D. Basement membrane

14

PMN tethering (aka rolling) to endothelium is mediated by which pair of receptors?
A. Chemokines and chemokine receptors
B. Integrins and integrin ligands
C. Selectins and selectin ligands
D. PECAM:PECAM

C. Selectins and selectin ligands

15

P-selectin is stored in which intracellular compartment?
A. Mast cell granule
B. PMN granule
C. Endothelial Weibel-Palade bodies
D. Monocyte/macrophage endosome
E. Epithelial body

C. Endothelial Weibel-Palade bodies

16

Which of the following cytokines is most likely to be involved in tissue repair and resolution of inflammation?
A. IFNγ
B. TNF
C. IL-1
D. IL-6
E. TGFβ

E. TGF-beta