Cytokines and their respective functions Flashcards Preview

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Flashcards in Cytokines and their respective functions Deck (26):
1

Most potent macrophage activator

IFN-gamma

2

Cytokines involved in wound healing

TGF-beta and IL-10

3

What induces IgG switching?

IFN-gamma (to IgG1 & 3).
IL-4 directs switching to IgG4

4

Pro-inflammatory cytokines

TNF and IL-1

5

What induces IgE switching?

Primarily IL-4
Also IL-5 (mostly through accumulation of eosinophils) and IL-13

6

What induces IgA switching?

IL-5 (weak against helminths) and TGF-beta

7

Cytokines involved in TH2 development

IL-4

8

TH2 T cell output

IL-4, IL-5, IL-13

9

Cytokines involved in TH17 development

IL-1, IL-6, TGF-beta and IL-23 (for stabilization of TH17 phenotype)

10

TH17 T cell output

IL-17, IL-22

11

Cytokines involved in TH1 development

IL-12

12

TH1 T cell output

IFN-gamma (major output), IL-2, TNF(alpha)

13

Cytokines involved in Treg T cell development

TGF-beta

14

Treg T cell output

TGF-beta, IL-10

15

Cytokine activators of NK cells

IL-2, IL-12 and IFN type I (enhances cytolytic capacity)

16

Activators of TH1 T cells

IL-2 (produced for autocrine use)

17

Cytokine produced by virally-infected host cells

IFN type I (alpha/beta)

18

Inhibitors of TH1 T cells

Everything produced by TH2 cells (IL-4, IL-5, IL-13) and everything produced by Treg cells (IL-10, TGF-beta)

19

What cytokine reduces expression of class II MHC?

IL-10

20

What cytokine up regulates expression of class I and II MHC?

IFN-gamma

21

Inhibitors of TH2 T cells

IFN-gamma

22

Cytokines that boost intestinal barrier

IL-17 and IL-22

23

Cytokine that causes synthesis and release of acute phase proteins

IL-6

24

Cytokines that induce neutrophilia

IL-1, TNF

25

Cytokines that cause fever

IL-1, TNF

26

Best recruiter of neutrophils

IL-8