Flashcards in Cytokines and their respective functions Deck (26):
Most potent macrophage activator
Cytokines involved in wound healing
TGF-beta and IL-10
What induces IgG switching?
IFN-gamma (to IgG1 & 3).
IL-4 directs switching to IgG4
TNF and IL-1
What induces IgE switching?
Also IL-5 (mostly through accumulation of eosinophils) and IL-13
What induces IgA switching?
IL-5 (weak against helminths) and TGF-beta
Cytokines involved in TH2 development
TH2 T cell output
IL-4, IL-5, IL-13
Cytokines involved in TH17 development
IL-1, IL-6, TGF-beta and IL-23 (for stabilization of TH17 phenotype)
TH17 T cell output
Cytokines involved in TH1 development
TH1 T cell output
IFN-gamma (major output), IL-2, TNF(alpha)
Cytokines involved in Treg T cell development
Treg T cell output
Cytokine activators of NK cells
IL-2, IL-12 and IFN type I (enhances cytolytic capacity)
Activators of TH1 T cells
IL-2 (produced for autocrine use)
Cytokine produced by virally-infected host cells
IFN type I (alpha/beta)
Inhibitors of TH1 T cells
Everything produced by TH2 cells (IL-4, IL-5, IL-13) and everything produced by Treg cells (IL-10, TGF-beta)
What cytokine reduces expression of class II MHC?
What cytokine up regulates expression of class I and II MHC?
Inhibitors of TH2 T cells
Cytokines that boost intestinal barrier
IL-17 and IL-22
Cytokine that causes synthesis and release of acute phase proteins
Cytokines that induce neutrophilia
Cytokines that cause fever