Ovarian Cancer Flashcards
(19 cards)
Commonest category of ovarian cancer?
Epithelial
Common findings on examination?
Abdominal bloating/distention, difficulty eating/feeling full quickly, or a persistent abdominal pain
We do a CA125 tumor marker for women, 85% of cancer patients have a reading higher than what
> 35U/mL
Best imaging to detect ovarian masses?
Transvaginal US and MRI
What is the Tumour staging classification called
FIGO
Stage 1 tumor means
Growth is limited to the ovaries
Tumour stage 1b means?
Involved both ovaries, not just one like A
Tumour stage 1c means?
Involves one or both ovaries, but has gone to shit
Tumor stage 1C means
Malignant cells in the peritoneal washing
The most valuable way of calculating the risk of malignancy is via?
Combining CA125 values, US findings, and menopausal status to thus calculate the RMI (risk of malignancy index)
Surgery is indicated in which stages?
Stages 1 and 2
Chemotherapy is combined to surgery with who and why?
Stage 2-4 this is because the cancer is invasive obviously
What is the upper limit of normal for CA-125 in postmenopausal women?
20U/mL
Which tumor marker is elevated in dysgerminoma?
LDH
What is the most common subtype of epithelial ovarian cancer?
Serous
Carboplatin + paclitaxel is what?
The first-line chemotherapy regimen
What is the most common site of distant metastasis in ovarian cancer?
Liver
35-year-old woman with a BRCA1 mutation asks about ovarian cancer prevention. What is the most effective prophylactic measure?
A) Annual CA-125 screening
B) Oral contraceptive use for 5+ years
C) Bilateral salpingo-oophorectomy
D) Transvaginal ultrasound every 6 months
B
Which chemotherapy drugs are first-line for ovarian cancer?
a) Doxorubicin + cyclophosphamide
b) Carboplatin + paclitaxel
c) Methotrexate + 5-FU
d) Bleomycin + etoposide
Carboplatin + paclitaxel
