Overview of Inflammation

Question 1

signs/symptoms of inflammation

Answer 1

redness, swelling, heat, pain

Question 2

acute inflammation

Answer 2

vascular changes and mediators, cellular events and mediators

Question 3

vascular changes in acute inflammation

Answer 3

vasodilation and increased vascular permeability.
Changes in the microvasculature promote fulid (edema) and inflammatory cell accumulation in the tissue at the site of injury

Question 4

vasodilation is mediated by

Answer 4

NO, PG’s, Histamine

Question 5

transudate

Answer 5

low protein content, low specific gravity, non-inflammatory–intact endothelium, inflammatory–early endothelial contraction

Question 6

exudate

Answer 6

high protein content, high spec gravity, fibrinous(protein and few cells) purulent (protein and many cells) sanguineous(protein and blood)

Question 7

mechanisms of increased vascular permeability include

Answer 7

endothelial contraction, endothelial retraction, and direct injury

Question 8

endothelial cell contraction

Answer 8

immediate-transient

mediated by PAF, histamine, bradykinin, leukotrienes

Question 9

direct endothelial injury mediated by

Answer 9

injurious agents or ROS/enzymes from PMNs

Question 10

Endothelial cell retraction mediated by

Answer 10

IL-1, TNF, IFN-y

Question 11

Pain

Answer 11

bradykinin, PGE2

Question 12

Fever

Answer 12

IL-1, TNF, PGE2