Oxytocics Tocolytics facts Flashcards
What is an oxytocic?
Stimulates uterine smooth muscle contraction
What is a tocolytic?
Uterine smooth muscle suppressor
What type of receptor is the oxytocin receptor?
Gq protein
When does oxytocin only work well in contraction?
Third trimester of pregnancy
What can oxytocin act like at high concentration?
ADH
How must oxytocin be given?
Anything not oral (it’s a peptide)
What do prostaglandins do during labor?
Raise levels of amniotic fluid
Induce myometrial contraction
Promote cervical ripening
How do ergots work?
Contract smooth muscle
What does ergot poisoning look like?
Nervous dysfunction (twisting, contortion, hallucinations) Gangrene in extremities
Which ergot is used for postpartum bleeding treatment?
Ergonovine/ergometrine
How do beta 2 receptor agonists act as tocolytics?
Activate adenylyl cyclase, decreasing myosin light chain kinase activity
What pregnancy condition is magnesium sulfate best to be used for?
Seizure prevention with eclampsia
Why should atosiban not be used?
Increases fetal mortality
When is indomethacin used?
Delays labor
When is ergotamine used?
Headache treatment
