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HRM - Pharmacology > Pituitary Pharmacology > Flashcards

Pituitary Pharmacology Flashcards

1
Q

Sermorelin

A

GHRH analogue

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2
Q

When is Sermorelin used in children?

A 
Promote growth in children with:
Hypopituiarism
Idiopathic shortness
Turner Syndrome
SHOX mutations
Trauma
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3
Q

When is Sermorelin used in adults?

A

Structural hypothalmic/pituitary deficiency
Surgery, irradiation
Trauma

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4
Q

Omnitrope

A

recombinant human growth hormone

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5
Q

Siazin

A

recombinant human growth hormone

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6
Q

Norditropin

A

recombinant human growth hormone

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7
Q

What do you monitor for rhGH dosing regimens?

A

IGF-1 and IBP3 levels

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8
Q

When are rhGH’s used?

A

Children: Growth
Adults: Lipid profile, fasting glucose, bone density

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9
Q

What are some side effects of rhGH’s?

A

Antibodies to GH sometimes
Scoliosis during rapid growth
Diabetogenic

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10
Q

Mecasermin

A

rhIGF

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11
Q

What are the side effects of mecasermin?

A

Hypoglycemia

CP450 induction

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12
Q

Bromocriptine

A

Dopamine agonist

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13
Q

Octreotide

A

Somatostatin analogue

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14
Q

Octreotide side effects?

A

Loos stools, cramps, malabsorption, nausea, flatulence, gall stones

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15
Q

Pegvisomant?

A

GH receptor antagonist

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16
Q

Side effects of pegvisomant?

A

Antibody formation

Liver toxicity

17
Q

What is bromocriptine used for?

A

Prolactin secretion control

18
Q

Cabergoline

A

Dopamine agonist, better efficacy for prolactin

19
Q

Cabergoline side effects?

A

nausea, vomiting, dizziness, orthostatic hypotension

HRM - Pharmacology (12 decks)

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