Reproductive Drugs Flashcards
When are natural gonadotropins used?
Produce ovulation
Multiple follicle porduction
PCOS
What are common side effects of gonadotropin stimulators?
Hyperstimulation
Multiple fetuses
Ovarian hyperstimulation syndrome
How should you use leuprolide to suppress FSH/LH?
Nonpulsatile administration
What do you initially see with leuprolide treatment?
FSH/LH transient increase
What effect does estrogen have on skeletal tissue?
Grows it
What limits the usefulness of estradiol 17b?
1st pass metabolism
How do you fix estradiol first pass metabolism?
addition of an acetylene group at C17
What are side effects of clomiphene citrate?
Nausea, vomiting, skin rashes
Hot flashes
Thromboembolic events
Endometrial cancer risk
What are uses of synthetic progestins?
Oral contraceptives Hormone replacement therapy Dysmenorrhea treatment Luteal support for pregnancy implantation Plan B
What are common side effects of oral contraceptives?
Depression Weight gain Nausea HTN DVT
Which tissues are targeted by testosterone?
Muscle
Seminal vesicle
Epididymis
Bone
What tissues are targeted by DHT?
Prostate
External genitalia
Skin (hair)
Where is most testosterone produced in a male?
95% leydig cells
5% adrenals
What are the desired androgenic effects of hormone replacement?
Treat hypogonadism
Treat hypopituitarism
What are the desired anabolic effects of androgens?
Muscle synthesis
Trauma treatment
Athletic performance
