(P7) Nervous Syst. Path. (Lab 26)

Question 1

Identify

Answer 1

Tuberculous meningitis

Question 2

Identify and Lable

Answer 2

Tuberculous meningitis

Brain Artery

Langhan’s Giant Cell

Purulent Exudate

Vessel Lymphocyte

Granuloma

Epithelioid Cell

Question 3

Identify

Answer 3

Abscess of the brain

Question 4

Identify and Label

Answer 4

Abscess of the brain

Congested vessel

Foci of neutrophils (purulent exude, pus)

Necrotic tissue

Blood vesse.

Hemorrhage

Question 5

Identify

Answer 5

Glioblastoma multiforme

Question 6

Identify and label

Answer 6

Glioblastoma multiforme

Area of hemorrhage

(Outline) Pseudopalisading of malignant nuclei

(Circled area) Pleomorphism

Question 7

Identify

Answer 7

Medulloblastoma

Question 8

Identify and Label

Answer 8

Medulloblastoma

Homer-Wright rosettes

Highly cellular - composed of masses of small oval/round cells

(circled) dense disperse cells surrounding vessel

Question 9

Identify

Answer 9

Meningioma

Question 10

Identify and Label

Answer 10

Meningioma

Psammoma body

(circled) Onion-skin arrangement surrounded by fibrous tissue (meningothelial cells)

(Dark cell) Meningothelial cells in associateoin with Psammoma bodies (calcified nodules)

Question 11

Identify

Answer 11

Schwannoma

Question 12

Identify and Label

Answer 12

Schwannoma

Palisading nuclei

Verocay Body (between palisading nuclei)

(Circle) Verocay Body

Question 13

Q. According to the general classification of inflammatory, this lesion represents teh following category?

Answer 13

• Tuberculous meningitis*
• -Granulomatous (proliferative)*

Question 14

Q. The lesion involves the following space ?

Answer 14

• Tuberculous meningitis*
• Subarachnoid space-

Question 15

Q. This lesion originates from the following type of cells?

Answer 15

• Glioblastoma multiforme*
• -Astrocytes-*

Question 16

Q. List 2 characteristic histological features of this lesion?

Answer 16

• Glioblastoma multiforme*
• -Marked cellularity and pleomorphism*
• -high mitotic rate*
• -presence of necrosis*
• -palisading of tumor cells around necrosis*

Question 17

Q. List 3 main groups of glial tumors according to histological (WHO)

Q. WHO grade?

Answer 17

Glioblastoma multiforme

• Astrocytic
• Ependymal
• Oligodendrocytes
• IV-

Question 18

Q. Name other lesion (known from previous labs) that contains the structure indicate on the slide?

Answer 18

• Meningioma*
• -Psammoma bodies (papillary carcinoma of the thyroid gland, other papillary adenocarcinoma*

Question 19

Q. Give the most common location of this lesion ?

Q. This lesion arises 90% in what Cranial Nerve?

Answer 19

• Schwannoma*
• -Cerebellum-*
• CN 8 (Vestibulocochlear: Hearing/balance)