Page15 Flashcards
(26 cards)
The nature of drug receptors present on cell membranes is
Protein
Tyrosine kinase receptors are present in
Outer cell membrane
Activation of cAMP-dependent mechanisms in cell membranes is a function of
Enzymes
Cytoskeletal structure connecting extracellular matrix to intracellular intermediate filaments
Integrin
Cytoskeletal to ECM connection
Integrin
Cytoskeletal ECM to ICM connection
Intermediate filament
ECM to ICM connection
Integrin
Cell to cell adhesion is mediated by
Cadherin
Firm adhesion is mediated by
LFA-1 > Integrin
Transient adhesion is mediated by
Selectins
Interwoven cytoskeletal network refers to
Intermediate filaments
Tumor spreads by
Loss of E-cadherin
Metastasis occurs due to
Degradation of E-cadherin
Mechanism of tumor metastasis is
Down regulation of E-cadherin
Structure that helps in transmission of rapid action potentials between cells
Gap junctions
Anatomical basis of conduction in the heart
Gap junctions
Heart acts as syncytium due to
Gap junctions
Desmosomes are made of
Cytokeratin, Cadherin, Intermediate filaments
Structure that connects two epithelial cells
Tight junction
Extracellular matrix and cytoskeleton communicate through
Integrin
Substance on endothelial cells promoting neutrophil migration in inflammation
E-selectin
Molecule aiding in transient adhesion of WBC to endothelium
Selectin
Child with leukocyte adhesion deficiency likely lacks
LFA-1
Initial tethering of leukocytes to endothelium is mediated by
Selectins
