Pancreas Flashcards

1
Q

How much enzymic HCO3- rich fluid does the pancreas produce per day

A

2L

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2
Q

What stimulates the release of enzymic HCO3- rich fluid from the pancreas

A

Cholecystokinin (CKK)

Secretin

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3
Q

What cell produces secretin and where

A

S-cells in the duodenum

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4
Q

What does secretin do

A

Controls gastric acid secretion and buffering with HCO3-

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5
Q

What cell produces CCK and where

A

I cells in the duodenum

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6
Q

What does CCK do

A

Causes release of digestive enzymes

Responsible for stimulating digestion of protein and fat

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7
Q

Vasoactive peptide which stimulates the secretion of H2O into the pancreatic system

A

D1

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8
Q

Criteria for metabolic syndrome

A
Fasting Hyperglycaemia (>6mmol/l)
Hypertension (>140/90mmHg)
Microalbuminuria 
Central obesity (>94cm M, >80cm F)
Dyslipidaemia (decrease HDL <1mmol/l AND increased TG >2mmol/l)
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9
Q

Diagnosis of diabetes mellitus

A

Fasting plasma glucose = >7mmol/l

Random blood glucose = >11.1 mmol/l

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10
Q

Renal complication of diabetes

A

Glomerulonephritis

Pyelonephritis

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11
Q

What scoring scale used for acute pancreatitis

A

GLASGOW scale

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12
Q

What score on Glasgow scale means patient should be referred to ITU

A

Score of 3 or more

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13
Q

I GETSMASHED

A
Idiopathic
Gallstones 
Ethanol 
Trauma 
Steroids 
Mumps 
Autoimmune
Scorpion venom
Hyperlipidaemia 
ERCP
Drugs e.g. thiazides
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14
Q

Most common cause of acute pancreatitis

A

Gallstones

50% in the U.K. due to this

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15
Q

The most common WORLDWIDE cause of acute pancreatitis

A

Alcohol

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16
Q

Drugs which can cause acute pancreatitis

A
furosemide
didanosine
oestrogens
azathioprine
thiazide diuretics
sulfonamides
tetracyclines
sulindac
mercaptopurine
valproic acid
L-asparaginase
17
Q

Histology of acute pancreatitis

A

Coagulative necrosis

18
Q

Sensitive test for acute pancreatitis

A

Serum lipase

19
Q

Most common cause of chronic pancreatitis

A

Alcohol

20
Q

Causes of chronic pancreatitis

A

Alcoholism
Hereditary eg CF
Autoimmune eg IgG4 sclerosing
Pancreatic duct obstruction eg stones/tumour

21
Q

Histology of chronic pancreatitis

A

Fibrosis and loss of exocrine tissue
Duct dilation with secretions
Calcification

22
Q

Acinar cell carcinoma has positive immunoreactivity for

A

Lipase
Trypsin
Chymotrypsin

23
Q

Histopathology of acinar cell carcinoma

A

Neoplastic epithelial cells with eosinophilic granular cytoplasm
Positive immunoreactivity for lipase, Tripsin and chymotripsin

24
Q

85% of all pancreatic malignancies

A

Ductal adenocarcinoma of the pancreas

25
Q

Common location of ductal adenocarcinoma of the pancreas

A

Head of the pancreas

26
Q

Tumour marker of ductal adenocarcinoma of pancreas

A

CA 19.9 (>70IU/mL)

27
Q

How are cells arranged in neuroendocrine tumours (islet cell tumours)

A

Nests or trabeculae with a granular cytoplasm

28
Q

VIPOMA

A
Vasoactive intestinal peptide 
Neuroendocrine tumour (islet cell tumour) 
Causes diarrhoea
29
Q

Gastrinoma causes

A

Zollinger Ellison syndrome which causes recurrent ulceration

30
Q

Which MEN has marfanoid phenotype

A

MEN 2B

31
Q

MEN 1

A

Parathyroid
Pancreatic endocrine tumour (often Phaeo)
Pituitary adenoma

32
Q

MEN 2A

A

Parathyroid
Thyroid
Phaeo

33
Q

Men2B

A

Medullary thyroid
Phaeo
Neuroma
Marfanoid phenotype

34
Q

A pancreatic malformation which which can present with duodenal obstruction in a 1 YO

A

Annular pancreas