Pancreas histo Flashcards

(38 cards)

1
Q

Where is the pancreas located in the body

A

retroperitoneal at level of 2nd lumbar

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

whic artery defines the neck of the pancreas

A

gastroduodenal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What lays antero superior to the pancreas

A

the stomach

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What merges directly behind the pancreas

A

superior mesenteric vein and portal vein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

At what level in the body is the tail of the pacreas approx at

A

T12

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

where does the pancreas terminate

A

within splenophrenic lig

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What part of the colon can be injured during a splenectomy

A

the splenic or R flexure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Describe the P difference in the common bile duct than pancreas

A

pancreas has higher P to proven backflow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what does the main pancreatic duct merge with and where

A

merges with common bile duct at the ampulla of Vater, main hepatopancreatic ampulla

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What does the acessory duct of Santorini drain

A

superior portion of head and empties separately into duodenum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Where do the superior pancreaticoduodenal aa come from

A

gastroduodenal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

where do the inferior pancreaticoduodenal aa come from

A

superior mesenteric

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

where does the dorsal pancreatic a come from

A

splenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

where does the great pancreatic a come from

A

splenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

where does the caudal pancreatic a come from

A

splenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Describe venous drainage of pancreas

A

anterior and posterior drain head and body to SMV or portal vein
splenic vein drains body and tail, ultimately to hepatic portal vein

17
Q

What are the 2 major components of the pancreas

A

acini and ducts

18
Q

what is the role of acinar cells

A

secrete digestive enzymes like amylase, lipase and trypsinogen

19
Q

What is the role of duct cells

A

secrete water and electrolytes

centroacinar and intercalated duct cells secrete bicarb

20
Q

what can larger duct cells secrete too

21
Q

What is the fluid like in the pancreas

A

alkaline and isoosmotic

22
Q

How can the pancreatic fluid be alkaline with digestive enzymes

A

enzymes ar activated in the duodenum by an acidic pH

23
Q

Is the pancreas more exocrine or endocrine

A

exocrine, less than 2% has endocrine functions

24
Q

What are the endocrine cells in the pancreas

A

islets of Langerhans

25
What are the 4 main cell types in the islets of langerhans
alpha that produce glucagon beta (majority) produce insulin and amylin delta produce somatostatin PP cells that produce pancreatic peptide
26
What are the 3 minor cell types in the islets of langerhans
delta 1 cells produce VIP EC beta cells that produce secretin, motilin and substance P epsilon cells that produce ghrelin
27
What are the 2 primary hormones secreted by pancreas
insulin when there is glucose | glucagon when there is low glucose
28
what does glucagon do
promote production of glucose in the liver
29
What are stimulatory inputs to insulin release
glucosem aa, glucagon, GIP, CCK, sulfonylurea, B sympathetic fibers
30
what are inhibitory inputs to insulin release
somatotstatin | amylin, pancreastatin, alpha sympathetic fibers
31
What is the role of pancreatic polypeptide
stimulates gastric chief cells inhibits bile secretion and intestinal motility inhibits pancreatic enzymes and HCO3 secretion
32
What is the role of vasoactive intestinal peptide VIP
similar to glucagon affects secretory and motility of gut stimulates pancreatic exocrine secretion
33
what is the role of secretin
acts locally to stimulate HCO3 secretion and enzyme secretion from pancreas
34
what is the role of motilin
increases gastric and intestinal motility
35
what is the role of substance P
neurotransmitter
36
what is the role of ghrelin
stimulates appetite
37
How are human islets arranged in the body
around so that all the cells can be in touch with vasculature
38
How does intercellular communication work in the pancreatic islets and what does this mean
islet-acinar axis or islet acinar portal system | does not need neuronal input to work