Pancytopenia and Bone Marrow Failures

Question 1

what cels are mutated in Polycythemia Rubra Vera

Answer 1

erythroid cells

Question 2

what are the clinical features of polycaetema rubra vera?

Answer 2

symtoms of high viscosity of blood

erythromyalgia

Question 3

What is erythromyalgia?

Answer 3

red painful extremites

Question 4

How is polycythaemia rubra vera investigated?

Answer 4

bloods - raised Hb

Question 5

How is polycythaemia rubra vera treated?

Answer 5

Venesection

Question 6

What is essential thombocythaemia>

Answer 6

clonal proliferation of megakaryocytes which results in excess rubbish platelets

Question 7

What are the features of essential thrombcythaemia?

Answer 7

lots of clots
bleeding (platelets are poor quality)
platelets over 1000