Flashcards in Papillomaviridae - General Characteristics Deck (10):
What is the general structure?
Circular double-stranded DNA
What is the key characteristic?
They produce warts on skin and mucous membranes of most animal species.
Are the warts benign or malignant?
Benign and they usually regress on their own.
Can a dog get infected with bovine papilloma?
No, they are all species and site specific.
Can the warts become malignant?
Occasionally. For example HPV causes cervical carcinoma in women.
Where does papilloma replicate?
Stratified squamous epithelium of the skin and some mucous membranes.
What does it mean that papillomavirus DNA is episomal?
It is not integrated into the host-cell DNA and can persist on its own.
What happens to the DNA in the case of malignant cancer?
The DNA becomes integrated into the host.
Integration disrupts E2 (a viral repressor)
E6 and E7 (viral oncogenes) remain intact and allow malignant transformation
When there is DNA damage, what protein usually steps in?
E6 prevents P53 from allowing cell suicide.