Flashcards in Past qs 22 Jan 2019 Deck (39)
Which clinical feature is characteristic to hydrogen sulphide toxicosis
- Lacrimation, nasal discharge
- Hard breathing
In which category does the toxic substance belong if the oral LD50 is 100mg/kg in rats?
B. Moderately toxic
Gentamicin is bound with high affinity to...
C. Phosphatidil inositol
What are the gross pathological signs in poisoning caused by anticoagulant rodenticides?
D. Haematomas and haemorrhages all over the body
Which antidote is NOT used in acute organophosphate toxicosis?
Which antidote can be used in lead toxicosis?
The most toxic organophosphates?
A. Contain fluorine atom
Which statement is true to nitrate-nitrite?
- Methemoglobin results from the presence of nitrite
- Monogastric animals are less sensitive to nitrates
Which compound is found in the venom of Solenopsis spp?
Which mechanism of action is characteristic to paraquat?
C. Induces the formation of free radicals in cells which bind to unsaturated fatty acids
What is the most toxic part of Golden chain?
Which pathological alteration is characteristic in urea poisoning?
- Ammonia odour of ruminal content
- Extreme bloating
What is NOT characteristic to dipyridyl derivatives?
B. Accumulate within the organism
Which factor can influence the absorption of the xenobiotics from the gastrointestinal tract?
- The lipid content of the feed
- The pH value of the certain part of the GI tract
Which medicine is useful in the treatment of poisoning by lupine spp?
- Hepatoprotective agents - Paraffin oil
How can the elimination of an acidic substance be facilitated via the kidney?
C. Alkalizing the urine with NaHCO3
Which antidote can be used in zinc toxicosis?
- Calcium disodium EDTA
In which category does the toxic substance belong if the oral LD50 is 20mg/kg in rats?
A. Highly toxic
What kind of treatment would you apply in paracetamol toxicosis?
- Vitamine C
Which animal species is most sensitive to zearalenone?
Which clinical signs are caused by Larkspur spp?
B. Muscle weakness, bloat in ruminants, sudden death
Which medicine is useful in the treatment of poisoning caused by drain cleaners?
Which compound is found in bee venom?
Which medicine is useful in the treatment of poisoning caused by anionic detergents?
Which pathological finding is characteristic to fumonisin poisoning?
- Transsudate is found in the airways and thoracic cavity in swine
- Edema and hemorrhagies are seen in the white matter of cerebral hemispheres
Which substance binds to a specific receptor in the synapsis?
Which mechanism of effect is characteristic to metaldehyde?
A. Damaging the neurotransmitters in the nerve synapses
Which clinical signs are caused by Poinsettia?
Antidote in the poisoning with diazinon and fenthion
Which antidote is a chelating agent?
C. Calcium disodium EDTA
Drug used for the treatment of ventricular arrhytmias in case of digoxin toxicosis?
Which clinical sign is NOT characteristic to ethylene glycol poisoning?
-How can iron-dextran be administered and in which animal species is this iron supplementation frequently used?
-Which is the most severe side effect after administration?
-Which 3 drugs are life-saving when this severe condition occurs?
-IM for piglets
-Norepinephrine, Antihistamine, Glucose
-In case of iron toxicosis which chelating agent can be used?
-Deferoxamine: 20 mg/kg, IM, 15 mg/kg/h IV
COMPLETE THE TABLE BELOW (16 points)
POISONING - ANTIDOTES - DOSE OF ANTIDOTES
1. Diazinon: Atropine/Pralidoxim - 0.2-0.5 mg/kg/20-50mg/kg
2. Amitraz: Atipamezole/Yohimbine - 5mg/m2/not used
3. Permethrin: Ø specific antidote
4. Paracetamol: Acetylcysteine - 140 (first), 70 mg/kg IV/PO 3x/day
5. Ethylene-glycole: Ethanol/Fomepizole - 5ml/kg, IV 20%/20mg/kg
6. Nitrate-Nitrite: Methylene blue - 5-10mg/kg (1%) IV
7. Dicumarol: Vitamin K1 - SA: 1-5mg/kg IV - LA: 0.5-1mg/kg IV
Which substance has enzyme inhibitory effect?
Which clinical feature is characteristic to sulphur dioxide toxicosis?
- Lung edema
- Lacrimation, coughing
What is the recommended dose of acetylcysteine in paracetamol poisoning?
B. 140mg/kg bw