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Flashcards in Past qs 22 Jan 2019 Deck (39)
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1

Which clinical feature is characteristic to hydrogen sulphide toxicosis

A. Both
- Lacrimation, nasal discharge
- Hard breathing

2

In which category does the toxic substance belong if the oral LD50 is 100mg/kg in rats?

B. Moderately toxic

3

Gentamicin is bound with high affinity to...

C. Phosphatidil inositol

4

What are the gross pathological signs in poisoning caused by anticoagulant rodenticides?

D. Haematomas and haemorrhages all over the body

5

Which antidote is NOT used in acute organophosphate toxicosis?

C. Fomepizole

6

Which antidote can be used in lead toxicosis?

A. Ca-Na-EDTA

7

The most toxic organophosphates?

A. Contain fluorine atom

8

Which statement is true to nitrate-nitrite?

D. Both
- Methemoglobin results from the presence of nitrite
- Monogastric animals are less sensitive to nitrates

9

Which compound is found in the venom of Solenopsis spp?

B. Alkaloids

10

Which mechanism of action is characteristic to paraquat?

C. Induces the formation of free radicals in cells which bind to unsaturated fatty acids

11

What is the most toxic part of Golden chain?

B. Seed

12

Which pathological alteration is characteristic in urea poisoning?

C. Both
- Ammonia odour of ruminal content
- Extreme bloating

13

What is NOT characteristic to dipyridyl derivatives?

B. Accumulate within the organism

14

Which factor can influence the absorption of the xenobiotics from the gastrointestinal tract?

B. Both
- The lipid content of the feed
- The pH value of the certain part of the GI tract

15

Which medicine is useful in the treatment of poisoning by lupine spp?

A. Both
- Hepatoprotective agents - Paraffin oil

16

How can the elimination of an acidic substance be facilitated via the kidney?

C. Alkalizing the urine with NaHCO3

17

Which antidote can be used in zinc toxicosis?

D. Both
- Calcium disodium EDTA
- D-penicillamine

18

In which category does the toxic substance belong if the oral LD50 is 20mg/kg in rats?

A. Highly toxic

19

What kind of treatment would you apply in paracetamol toxicosis?

A. Both
- Acetylcysteine
- Vitamine C

20

Which animal species is most sensitive to zearalenone?

B. Swine

21

Which clinical signs are caused by Larkspur spp?

B. Muscle weakness, bloat in ruminants, sudden death

22

Which medicine is useful in the treatment of poisoning caused by drain cleaners?

C. Both
- Neutralisation
- Dilution

23

Which compound is found in bee venom?

C. Cholinesterase

24

Which medicine is useful in the treatment of poisoning caused by anionic detergents?

A. Both
- Neutralisation
- Dilution

25

Which pathological finding is characteristic to fumonisin poisoning?

B. Both
- Transsudate is found in the airways and thoracic cavity in swine
- Edema and hemorrhagies are seen in the white matter of cerebral hemispheres

26

Which substance binds to a specific receptor in the synapsis?

D. Atropine

27

Which mechanism of effect is characteristic to metaldehyde?

A. Damaging the neurotransmitters in the nerve synapses

28

Which clinical signs are caused by Poinsettia?

D. Both
- Diarrhea
- Conjunctivitis

29

Antidote in the poisoning with diazinon and fenthion

C. Atropine

30

Which antidote is a chelating agent?

C. Calcium disodium EDTA

31

Drug used for the treatment of ventricular arrhytmias in case of digoxin toxicosis?

B. Lidocain

32

Which clinical sign is NOT characteristic to ethylene glycol poisoning?

A. Diarrhoea

33

-How can iron-dextran be administered and in which animal species is this iron supplementation frequently used?
-Which is the most severe side effect after administration?
-Which 3 drugs are life-saving when this severe condition occurs?

-IM for piglets
-Anaphylactoid reaction
-Norepinephrine, Antihistamine, Glucose

34

-In case of iron toxicosis which chelating agent can be used?

-Deferoxamine: 20 mg/kg, IM, 15 mg/kg/h IV

35

COMPLETE THE TABLE BELOW (16 points)
POISONING - ANTIDOTES - DOSE OF ANTIDOTES
1. Diazinon
2. Amitraz
3. Permethrin
4. Paracetamol
5. Ethylene-glycole
6. Nitrate-Nitrite
7. Dicumarol

1. Diazinon: Atropine/Pralidoxim - 0.2-0.5 mg/kg/20-50mg/kg
2. Amitraz: Atipamezole/Yohimbine - 5mg/m2/not used
3. Permethrin: Ø specific antidote
4. Paracetamol: Acetylcysteine - 140 (first), 70 mg/kg IV/PO 3x/day
5. Ethylene-glycole: Ethanol/Fomepizole - 5ml/kg, IV 20%/20mg/kg
6. Nitrate-Nitrite: Methylene blue - 5-10mg/kg (1%) IV
7. Dicumarol: Vitamin K1 - SA: 1-5mg/kg IV - LA: 0.5-1mg/kg IV

36

Which substance has enzyme inhibitory effect?

D. Tiamulin

37

Which clinical feature is characteristic to sulphur dioxide toxicosis?

C. Both
- Lung edema
- Lacrimation, coughing

38

What is the recommended dose of acetylcysteine in paracetamol poisoning?

B. 140mg/kg bw

39

WHICH IS THIS PLANT? (2points)
1. This plant damages the bone marrow. It contains also thiaminase and carcinogenic compound. Bleeding in different forms is typical symptom in case of poisoning.
2. This garden plant also contains alkaloids, glycosides and Ca-oxalate. Its bulb is very toxic. It can cause erythema in case of direct skin contact.

1. Bracken fern
2. Daffodil spp (poet’s daffodil, wild daffodil)