Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

FA > Path > Flashcards

Path Flashcards

1
Q

BAX

A

pro-apoptotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Bcl-2

A

anti-apoptotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

neutrophil rolling

A

E/P-selectin –> sialyl-lewisX

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

neutrophil tight binding

A

ICAM1 –> LFA-1 (integrin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

neutrophil diapedesis

A

PECAM1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

neutrophil migration

A

CILK - C5a, IL-8, LTB4, Kallikrein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

disease conditions associated with down syndrome

A

ALL, AML

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

disease conditions associated with xeroderma pigmentosum, albinism

A

melanoma, basal cell carcinoma, squamous cell carcinoma of skin**

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

disease conditions associated with tuberous sclerosis (facial angiofibroma, seizures, mental retardation)

A

giant cell astrocytoma, renal angiomyolipoma and cardiac rhabdomyoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

disease conditions associated with actinic keratosis

A

squamous cell carcinoma ofskin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

disease conditions associated with barrett’s esophagus (chronic GI reflux)

A

esophageal adenocarcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

disease conditions associated with plummer-vinson syndrome (low iron)

A

squamous cell caricnoma of esophagus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

disease conditions associated with cirrhosis (alcoholic, hep B or B)

A

hepatocellular carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

disease conditions associated with ulcerative colitis

A

colonic adenocarcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

disease conditions associated with pagets disease of bone

A

secondary osteosarcoma and fibrosarcoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

disease conditions associated with immunodeficiency states

A

malignant lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

disease conditions associated with AIDS

A

aggressive malignant lymphoma (NH) and kaposis sarcoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

disease conditions associated with autoimmune diseases (hashimoto, MG)

A

lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

disease conditions associated with acanthosis nigricans (hyperpigmentation and epidermal thickenign)

A

visceral malignancy (stomach, lung, uterus)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

disease conditions associated with dysplastic nevus

A

malignant melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

disease conditions associated with radiation exposure

A

leukema, sarcoma, papillary thyroid cancer, breast cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

abl

A

oncogene* CML –> tyrosine kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

c-myc

A

oncogene* burkitts lymphoma –> transcription factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

bcl-2

A

oncogene* follicular and undifferentiation lymphomas (inhibits apoptosis) –> anti-apoptotic molecule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
HER2/neu (c-erbB2)
oncogene* breast ovarian and gastric carcinoma --> tyrosine kinase
26
ras
oncogene* colon carcinoma --> GTPase
27
L-myc
oncogene* lung tumor --> transcription factor
28
N-myc
oncogene* neuroblastoma --> transcription factor
29
ret
oncogene* MEN 2a and 2b --> tyrosine kinase
30
c-kit
oncogene* GI stromal tumor --> cytokine receptor
31
Rb
tumor suppressor gene* retinoblastoma, osteosarcoma --> inhibits E2F; blocks G --> S phase
32
p53
tumor suppressor gene* most human cancers, li-fraumenni syndrome --> transcription factor for p21, blocks G1 --> S
33
BRCA1 and BRCA2
tumor suppressor gene* breast and ovarian cancer --> DNA repair protein
34
p16
tumor suppressor gene* melanoma
35
BRAF
tumor suppressor gene* melanoma --> B-raf
36
APC
tumor suppressor gene* colorectal cancer (FAP)
37
WTT
tumor suppressor gene* Wilms tumor (nephroblastoma)
38
NF1
tumor suppressor gene* neurofibromatosis type 1 --> RAS GTPase activating protein (RAS-GAP)
39
NF2
tumor suppressor gene* neurofibromatosis type 2 --> merlin (schwannomin) protein
40
DPC4
tumor suppressor gene* pancreatic cancer --> DPC = DELETED IN PANC CANCER
41
DCC
tumor suppressor gene* colon cancer --> DCC = DELETED IN COLON CANCER
42
PSA
prostate specific antigen
43
prostatic acid phosphatase
prostate carcinoma
44
CEA
carcinoembryonic antigen
45
alpha fetoprotein
hepatocellular carincoma | nonseminmotous germ cell tumors (testis/ovarY)
46
beta-HCG
hydatidiform moles and choriocarcinomas (gestational trophoblastic disease)
47
CA-125
ovarian cancer
48
S-100
melanoma, neural tumors, schwannoma
49
alkaline phosphatase
metastases to bone, liver, pagets disease of bone
50
bombesin
neuroblastoma, lung and gastric cancer
51
TRAP
hairy cell leukemia - B cell neoplasm
52
CA-19-9
pancreatic adenocarcinoma
53
calcitonin
medullary thyroid carcinoma
54
HTLV-1
adult T-cell leukema/lymphoma
55
HBV/HCV
hepatocellular carcinoma
56
EBV
burkitts lymphoma, hodgkins lmohoma, nasopharyngeal carcinoma, CNS lymphoma (IC patients)
57
HPV
cervical carcinoma (16,18), penile/anal carcinoma, upper resp SCC
58
HHV-8 (kaposi's sarcoma-associated herpesvirus)
kaposis sarcoma, body cavity fluid B-cell lymphoma
59
H. pylori
gastric adenocarcinoma and lymphoma
60
schistosoma haematobium
bladder cancer (squamous cell)
61
liver fluke (clonorchis sinensis)
cholangiocarcinoma
62
aflatoxin (aspergillus)
liver --> hepatocellular carcinoma
63
vinyl chloride
liver --> angiosarcoma
64
carbon tetrachloride
liver --> centrilobular necrosis, fatty change
65
nitrosamines (smoked foods)
stomach --> gastric cancer
66
cig smoke
``` larynx --> squamous cell carcinoma lung --> squamous cell and small cell carcinoma kidnye --> renal cell carcinoma bladder --> transitional cell carcinoma pancreas --> panc adenocarcinoma ```
67
asbestos
lung --> bronchogenic carcinoma > mestholeioma
68
arsenic
skin --> squamous cell carcinoma | liver --> angiosarcoma
69
naphthalene (aniline) dyes
bladder --> transitional cell carcinoma
70
alkylating agents
blood --> leukemia
71
ACTH
cusshings syndrome --> small cell lung carcinoma
72
ADh
SIADH --> small cell lung carcinoma and intracranial neoplasma
73
PTHrP
hypercalcemia --> squamous cell lung carcinoma, renal cell carcinoma, breast cnacer
74
1,25-OH2 D3 = calcitrol
hypercalcemia --> hodgkins lymphoma, some NHL
75
erythropoietin
polycythemia --> renal cell carcinoma, hemagioblastoma, hepatocellular carcinoma, pheochromocytoma
76
antibodies vs presynaptic calcium channels at NMJ
lambert eaton syndrome (muscle weakness) --> small cell lung carcinoma
77
psammoma bodies
laminted concentrated calcific spherules seen in papillary andenocarcinoma or thyroid, serous papillary cystadenocarcinoma of ovary, meningioma, malignant mesothelioma

FA (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions