Path 3 final Histology Flashcards Preview

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Flashcards in Path 3 final Histology Deck (57)
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1

Cystic medial necrosis: weakening of connective tissue

Pink elastic fibers are disrupted by pools of blue mucinous ground substance

2

Liver congestion due to CHF

persinusoidal fibrosis and centrilobular sinusoidal dilation

3

Dilated cardiomyopathy

nonspecific cellular abnormalities: variation in myocyte size, vacuolation, loss of myofibrillar material and fibrosis

4

Hypertrophic cardiomyopathy

Hypertrophic myocardial fibers with prominent dark nuclei along with interstitial fibrosis

5

REstrictive cardiomyopathy: hemochroatosis

Prussian blue stain: excessive deposition of iron

6

Restrictive cardiomyopathy: amyloidosis

amorphous deposits of pale pink material between myocardial fibers

7

viral myocarditis

interstitial lymphocytic infiltrates: Note most common viral agent: Coxsackie virus

8

Rheumatic fever

Achoff bodies

9

Atrial myoxoma

Hypocellular myxoid mass with polygonal cells or elongated cell shape. Mono or multinuclear Finely vacuolated eosinophilic (stain) cytoplasms

10

Metastatic melanoma

areas of brown/black pigment: characteristic of melanoma

11

Achalasia

Lymphocytic infiltration of Auerbach's plexus eventually overtaking ganglion cells

12

Barrets Esophagus

Metaplasia: Normal stratified squamous epithelium change to gastric and/or colonic columnar cells

Characteristic goblet cells

NOTE: colonic cells are associated with increased risk of malignancy

13

 Espohageal Adenocarcinoma

variable nuclear size,  variable nuclear staining and variable

nuclear shape.

Mitotic figures in the neoplastic cells are abundant.

 

14

Acute Gastritis

Gastric mucosa invaded with infiltration of neutrophils

15

Heliobactor Pylori

Small curved to spiral rod-shaped bacterium is found

in the surface epithelial mucus: methylene blue stain.  

16

Atrophic Gastritis

Intestinal-type epithelium with numerous goblet cells (stained blue with the Alcian blue stain) has replaced the normal gastric mucosa. Mild chronic inflammation is noted by the presence of neutrophils in the lamina propria. 

17

Gastric adenocarcinoma

The neoplastic glands of gastric adenocarcinoma demonstrate mitoses, increased nuclear/cytoplasmic ratios and hyperchromatism

Signet ring cell pattern

Gastric glands not visible

18

Gastric lymphoma

Infiltration of mucosa by atypical lymphoid  cells

Characteristic: lymphoepitheleal lesions

19

Carcinoid tumor (gastric)

"Endocrine pattern" (nests of cells separated by thin-walled vessels) with less than 2 mitoses/10 HPF. Uniformity of cells and nuclei, normal nuclear/cytoplasmic ratio, small nucleoli, stippled chromatin

20

Celiac DZ

Blunting/flattening of intestinal villi

 

Note: DQw2 histocompatibility antigen shows in 95% of patients

21

Chron's DZ

Transmural lesions

Inflammatory cells appear as nodular infiltrates on the serosal surface with pale granulomatous centers.

epithelioid cells, giant cells, and many lymphocytes

22

Ulcerative Colitis

Crypt Abcesses

Neutrophilic exudate is found in glandular lumens.

The submucosa shows intense inflammation. The glands demonstrate loss of goblet cells and hyperchromatic nuclei with inflammatory atypia.

 

**Increased risk for adenocarcinoma

23

Solid psuedopallilary tumor

sheets of cells of similar size which display uniformly shaped and sized nuclei and slightly eosinophilic staining cytoplasm

 

Necrosis is often present and cell death may lead to changes in which finger-like projections of cells, known as pseudopapillae

24

Mucinous Cystadenoma

 “empty” appearing cells

(no nucleus or obvious cytoplasmic structures).

These are the mucin containing cells.

25

Serous cystadenoma

small cysts which are lined by ciliated cuboidal epithelium, characteristic of serous cystadenoma

26

Pseudomembranous enterocolitis

Pseudomembrane has numerous inflammatory cells, mainly neutrophils.

Pseudomembrane is usually composed of inflammatory cells, necrotic epithelium, and mucus in which the overgrowth of microorganisms takes place.

27

Leiomyoma

Elongated spindle cells containing cigar-shaped nuclei

NO evidence of increased mitotic activity is seen

28

Peutz-Jeghers Syndrome

Distinctive frond-like appearance with a stromal/smooth muscle core

Covered by acinar glands and normal mucosa.

Nuclear atypia is absent

29

Carcinoid Tumor (Intestine)

Nests of carcinoid tumor have a typical endocrine appearance

collections of small round cells containing nuclei

that are consistent in size and shape and surrounded by cytoplasm which stains pink to pale blue. 

30

Adenomatous polyp

Glands that are more irregular

contain darker and more crowded nuclei.

This neoplasm is benign and well-differentiated, as it still closely resembles the normal colonic structure