Path 3 Renal and Bladder Tumors Flashcards Preview

Test 9 > Path 3 Renal and Bladder Tumors > Flashcards

Flashcards in Path 3 Renal and Bladder Tumors Deck (34)
Loading flashcards...
1
Q

Renal Papillary Adenoma

A

Bening tumor of Renal Tubular Epithelium

2
Q

Renal Papillary Adenoma histo

A

Complex, branching, papillomatous structures (typical adenoma)

3
Q

Oncocytoma

A

Benign tumor of Collecting Duct Intercalated Cells

4
Q

Oncocytoma gross, histo

A

Well circumscribed with central scar

-Large eosinophilic epithelial cells (numerous mitochondria)

5
Q

Angiomyolipoma

A

Benign tumor of vessels, muscle, and fat

  • Tuberous Sclerosis association
  • Bleeds spontaneously
6
Q

Tuberous Sclerosis

A

Loss of function of TSC tumor suppressor gene

  • Cerebral Cortex lesions, Epilepsy, Mental Retardation
  • SEGA (subependymal giant cell angiosarcoma)
  • Angiofibromas, Rhabdomyomas, Angiomyolipomas
7
Q

Renal Cell Carcinoma causes

A

Most common malignant tumor

  • Tobacco use
  • Chronic renal failure, acquired cystic disease, tuberous sclerosis
8
Q

Familial causes of Renal Cell Carcinoma (3)

A
  • VHL disease (renal cysts, multiple bilateral RCCs)
  • Hereditary (familial) Clear Cell Carcinoma (same gene as VHL)
  • Hereditary Papillary Carcinoma (MET proto-oncogene mutation)
9
Q

Von Hippel-Lindau disease

A

Deletion of VHL on ch. 3p

  • Multiple Clear cell renal carcinomas
  • CNS & retinal hemangioblastomas
10
Q

Renal cell carcinoma typical features

A

Arise in poles of kidney

-Invade renal vein

11
Q

Clear Cell Carcinoma

A

95% are sporadic

  • Mutation on chromosome 3
  • Polygonal cells containing glycogen and lipid
12
Q

Papillary carcinoma

A

Associated with dialysis cystic disease

-Frequently multifocal

13
Q

Papillary carcinoma histo

A

Psammoma bodies

-Foamy macrophages

14
Q

Chromophobe renal carcinoma

A

Excellent prognosis

15
Q

Chromophobe renal carcinoma histo

A

Distinction from oncocytoma difficult

  • Eosinophilic cytoplasm with halo around nucleus
  • Prominent cell membranes
16
Q

Collecting (Bellini) duct carcinoma histo

A

Nests of malignant cells in medullary fibrotic stroma

-Irregular channels

17
Q

Renal cell carcinoma clinical

A
  • Costovertebral pain
  • Palpable Mass
  • Hematuria
18
Q

Renal cell carcinoma metastasis locations

A

Lungs (50%)

Bones (30%)

19
Q

Urothelial Carcinoma of Renal Pelvis clinical

A
  • Clinically apparent quickly (obstruction, hematuria)
  • Poor prognosis
  • 50% preexisting bladder tumor
20
Q

Urothelial carcinoma cause

A

Analgesic nephropathy

Preexisting bladder urothelial tumor

21
Q

Urothelial bladder carcinoma clinical

A

Prognosis depends on invasion of muscularis propria (detrusor muscle)

22
Q

Urothelial bladder carcinoma precursors

A
  • Non-invasive papillary tumor (reg, inverted)

- Flat non-invasive urothelial carcinoma

23
Q

Bladder papillary tumor Tx

A

Excision

24
Q

Low grade papillary urothelial carcinomas

A

-Can recur and invade

25
Q

High grade papillary urothelial carcinoa

A

80% invade into muscularis

-May produce fistulas

26
Q

Pagetoid spread

A

Flat urothelial carcinoma (in situ)

27
Q

Squamous cell carcinoma of the bladder

A

Shistosomiasis

28
Q

Adenocarcinoma of the bladder

A

Urachal remnants or extensive intestinal metaplasia

29
Q

Bladder cancer etiology (5)

A
  • Tobacco
  • Arylamines
  • Schistosoma
  • Analgesics
  • Cyclophosphamide (immunosuppressant)
30
Q

Bladder cancer clinical

A

Painless hematuria

-Tendency for higher grade recurrence after excision

31
Q

Bladder cancer Dx

A

Urine FISH

Cytoscopy & biopsy

32
Q

Bladder cancer Tx

A

Excision

  • Intravesicular BCG to prevent recurrence
  • Radical cystectomy for invasive cancer
33
Q

Urethral caruncle

A

-Painful inflammatory lesion of urethra in older females

34
Q

Peyronie disease

A

Fibrous bands involving corpus cavernosum