Path 3 Renal and Bladder Tumors Flashcards Preview

Test 9 > Path 3 Renal and Bladder Tumors > Flashcards

Flashcards in Path 3 Renal and Bladder Tumors Deck (34):
1

Renal Papillary Adenoma

Bening tumor of Renal Tubular Epithelium

2

Renal Papillary Adenoma histo

Complex, branching, papillomatous structures (typical adenoma)

3

Oncocytoma

Benign tumor of Collecting Duct Intercalated Cells

4

Oncocytoma gross, histo

Well circumscribed with central scar
-Large eosinophilic epithelial cells (numerous mitochondria)

5

Angiomyolipoma

Benign tumor of vessels, muscle, and fat
-Tuberous Sclerosis association
-Bleeds spontaneously

6

Tuberous Sclerosis

Loss of function of TSC tumor suppressor gene
-Cerebral Cortex lesions, Epilepsy, Mental Retardation
-SEGA (subependymal giant cell angiosarcoma)
-Angiofibromas, Rhabdomyomas, Angiomyolipomas

7

Renal Cell Carcinoma causes

Most common malignant tumor
-Tobacco use
-Chronic renal failure, acquired cystic disease, tuberous sclerosis

8

Familial causes of Renal Cell Carcinoma (3)

-VHL disease (renal cysts, multiple bilateral RCCs)
-Hereditary (familial) Clear Cell Carcinoma (same gene as VHL)
-Hereditary Papillary Carcinoma (MET proto-oncogene mutation)

9

Von Hippel-Lindau disease

Deletion of VHL on ch. 3p
-Multiple Clear cell renal carcinomas
-CNS & retinal hemangioblastomas

10

Renal cell carcinoma typical features

Arise in poles of kidney
-Invade renal vein

11

Clear Cell Carcinoma

95% are sporadic
-Mutation on chromosome 3
-Polygonal cells containing glycogen and lipid

12

Papillary carcinoma

Associated with dialysis cystic disease
-Frequently multifocal

13

Papillary carcinoma histo

Psammoma bodies
-Foamy macrophages

14

Chromophobe renal carcinoma

Excellent prognosis

15

Chromophobe renal carcinoma histo

Distinction from oncocytoma difficult
-Eosinophilic cytoplasm with halo around nucleus
-Prominent cell membranes

16

Collecting (Bellini) duct carcinoma histo

Nests of malignant cells in medullary fibrotic stroma
-Irregular channels

17

Renal cell carcinoma clinical

-Costovertebral pain
-Palpable Mass
-Hematuria

18

Renal cell carcinoma metastasis locations

Lungs (50%)
Bones (30%)

19

Urothelial Carcinoma of Renal Pelvis clinical

-Clinically apparent quickly (obstruction, hematuria)
-Poor prognosis
-50% preexisting bladder tumor

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Urothelial carcinoma cause

Analgesic nephropathy
Preexisting bladder urothelial tumor

21

Urothelial bladder carcinoma clinical

Prognosis depends on invasion of muscularis propria (detrusor muscle)

22

Urothelial bladder carcinoma precursors

-Non-invasive papillary tumor (reg, inverted)
-Flat non-invasive urothelial carcinoma

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Bladder papillary tumor Tx

Excision

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Low grade papillary urothelial carcinomas

-Can recur and invade

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High grade papillary urothelial carcinoa

80% invade into muscularis
-May produce fistulas

26

Pagetoid spread

Flat urothelial carcinoma (in situ)

27

Squamous cell carcinoma of the bladder

Shistosomiasis

28

Adenocarcinoma of the bladder

Urachal remnants or extensive intestinal metaplasia

29

Bladder cancer etiology (5)

-Tobacco
-Arylamines
-Schistosoma
-Analgesics
-Cyclophosphamide (immunosuppressant)

30

Bladder cancer clinical

Painless hematuria
-Tendency for higher grade recurrence after excision

31

Bladder cancer Dx

Urine FISH
Cytoscopy & biopsy

32

Bladder cancer Tx

Excision
-Intravesicular BCG to prevent recurrence
-Radical cystectomy for invasive cancer

33

Urethral caruncle

-Painful inflammatory lesion of urethra in older females

34

Peyronie disease

Fibrous bands involving corpus cavernosum