Pharm 5 Androgens Flashcards Preview

Test 9 > Pharm 5 Androgens > Flashcards

Flashcards in Pharm 5 Androgens Deck (23):
1

Primary stimulator of testosterone synthesis and androgen-binding globulin

LH - testosterone (leydig cells)
FSH - ABG

2

LH, FSH stimulated by

GnRH (pulsatile)

3

LH, FSH inhibitors (male)

Testosterone, Estradiol

4

Site of female androgen synthesis

Corpus luteum

5

Testosterone metabolism

5a-reductase -> dihydrotestosterone
P450 aromatase (CYP19) -> estradiol

6

5a reductase & CYP19 locations

5a reductase - Skin, bone, liver, genitals
CYP19 aromatase - Fat, liver, bone

7

Testosterone action

A-R ->
-Internal genitalia (Wolffian development)
-Skeletal muscle (puberty)
-Erythropoiesis

8

Dihydrotestosterone action

A-R ->
-Eternal genitalia (differentiation and maturation)
-Hair follicles (puberty)

9

Estradiol action

E-R ->
-Bone density and epiphyses closure
-Regulation of male reproductive tract fluid

10

Transdermal androgen Tx

Testosterone

11

IM deposit androgen Tx

Testosterone cypionate

12

Oral androgen Tx

-Methyltestosterone
-Oxandrolone
-Danazol

13

Endometriosis androgen Tx

Danazol

14

Unusual clinical uses for androgens

Hereditary angioedema
-AIDS muscle wasting
-Severe anemia (stimulate erythropoiesis)

15

Androgen Tx tumor risk

Liver tumors

16

Androgen Tx contraindications (3)

Pregnancy
Prostate/Breast cancer
Infants/Young children

17

-Danazol-
MOA
indications

Weak androgen, progestin, glucocorticoid
-INHIBITS gonadal steroidogenesis
-Endometriosis, Fibrocystic breast disease

18

-Ketoconazole-
indication

Inhibits P450 required for steroid synthesis
-Prostate cancer

19

-Finasteride-
MOA
indication

5a-reductase inhibitor
-Blocks dihydrotestosterone production
-Benign prostatic hyperplasia

20

-Flutamide-
indication

Nonsteroidal competitive A-R antagonist
-Prostate cancer

21

-Spironolactone-
MOA
indication

Blocks Aldosterone-R and Androgen-R
-Inhibits 17a-hydroxylase
-Hirsutism

22

-Tetrahydrogestrinone-
indication

The "clear" - THG
-Designer steroid to avoid drug test detection

23

Steroid abuse AE

-Retention of sodium and water
-CAD risk (+LDL, -HDL)
-Severe acne
-Hyperinsulinemia, altered glucose tolerance
-Liver toxicity
-Premature bone fusion
-Testicular atrophy and gynecomastia