Path Flashcards
Fibrocystic change
usually benign, some changes associated with increased risk for invasive carcinoma cystic breasts blue dome gross appearance
Anitschkow cells are plump macrophages seen in what dx?
Rheumatic heart disease (beta hemolytic, group A streptococcus) Anitschkow cells are part of the Aschoff bodies lesions
What drugs cause interstitial nephritis?
sulfonamides, penicillins, cephalosporins, the fluoroquinolone antibiotics ciprofloxacin and norfloxacin, and the antituberculous drugs isoniazid and rifampin. Acute tubulointerstitial nephritis also can occur with use of thiazide and loop diuretics, cimetidine, ranitidine, omeprazole, and nonsteroidal anti-inflammatory drugs. The disease manifests about 2 weeks after the patient begins to use the drug.
What is the effect of the following teratogen?
Phenytoin
Digit hypoplasia and cleft lip/palate
Anti-DNA topoisomerase antibody is seen in:
scleroderma (mainly affects vasculature of kidney)
What is the diagnosis? Benign cystic tumor with abundant lymphocytes and germinal centers; Almost always arises in the parotid
Warthin tumor 2nd most common tumor of the salivary gland
Name the dx:
The orifice of the prepuce cannot allow retraction over the glans penis, and can strangulate the glans and impede the outflow of venous blood
Phimosis
Complication when blood flow is obstructed is paraphimosis
Same small lymphocytes as CLL, but appearing in tissue and not blood; widespread lymphadenopathy; liver and spleen enlargement; lymphocytosis
Small lymphocytic lymphoma
Lobular Carcinoma In Situ (LCIS)
discohesive cells lacking E-cadherin
no mass or calcifications
treatment with tamoxifen
**LCIS, more than DCIS, serves as a marker for enhanced risk of subsequent invasive carcinoma in both breasts
Volvulus is found in the elderly in:
sigmoid colon
Neurogenic bladder
Control of micturition is disrupted by spinal cord transection above the sacral cord, and detrusor hyperreflexia can occur in this instance.
Blockade of muscarinic acetylcholine receptors with agents like tolterodine and other antispasmodics can decrease this parasympathetic-related hyperactivity.
Invasive Lobular Carcinoma
second most common form of invasive breast cancer
can be a discrete firm mass or not
single strands or lines of cells with stroma in between
Labs Hep B:
ALT>AST, in the thousands; Bili high
Name the diagnosis:
recent acute Hep B infection; ANCA (+); Proteinuria; Fever, muscle pain, weight loss; Lesions on legs - reddish-blue; Elevated ESR
Polyarteritis nodosa
small to medium arteries
fibrinoid necrosis = eosinophilic mass that stains for fibrin
Frataxin is essential for what?
Mitochondrial iron regulation;
loss results in iron build-up with free radical damage;
this is the gene impaired in Friedreich Ataxia
Frataxin, Fe, Free radical damage, Friederich Ataxia
CK activity does what after an MI?
CK activity begins to increase 2 to 4 hours after an MI, peaks at about 24 to 48 hours, and returns to normal within 72 hours. Total CK activity is a sensitive marker for myocardial injury in the first 24 to 48 hours.
Hep C is Sexual?
Not really, Hep B is sexually transmitted Hep C is blood (tattoos, IV drug use)
Most common breast cancer in men:
Invasive ductal carcinoma (still very rare)
BRCA2 plays a role
Name the disorder characterized by: 1. Platelet destruction secondary to heparin therapy 2. May cause thrombosis from destroyed platelets activating remaining platelets
Heparin-induced thrombocytopenia
Desquamative interstitial pneumonitis is related to what predisposition?
Desquamative interstitial pneumonitis (DIP) is an uncommon smoking-related interstitial disease in which monocytes gather to form intra-alveolar macrophages.
Necrotizing vasculitis occurs in pulmonary vasculature in association with:
Necrotizing vasculitis occurs in pulmonary vasculature in association with anti–neutrophil cytoplasmic autoantibody (ANCA)–associated granulomatous vasculitis.
Dental caries are most often caused by:
Strep mutans
Prevention is fluoride
A 10-year-old girl develops subcutaneous nodules over the skin of her arms and torso 3 weeks after a bout of acute pharyngitis. She manifests choreiform movements and begins to complain of pain in her knees and hips, particularly with movement. A friction rub is heard on auscultation of her chest. An abnormality detected by which serum laboratory finding is most characteristic of the disease affecting this girl?
anti–streptolysin O (ASO) titer
Acute rheumatic fever can involve any or all layers of the heart. Because rheumatic fever follows group A streptococcal infections, the antihyaluronidase, anti-DNase, and anti–streptolysin O (ASO) titers are often elevated.
What is the anatomical (as opposed to clinical) result of an ischemic stroke?
Liquefactive necrosis
Eosinophilic change –> Necrosis –> fluid-filled cystic space surrounded by gliosis

