PAth: Bone: 3 Flashcards
What is MC mesenchymal tumor
lipoma
CP of lipoma:
small mass beneath skin, some deep within soft tissue
Ewing’s marker (a number CD…)
CD 99
rhabdomyosarcoma marker ( a word)
Desmin
marker for hematopoietic cells (CD…)
CD45 =
Ewing sarcoma: histo, CP mimics what?
small, round blue-cell tumor\
CP: mimics osteomyelitis (pain, mass, pathologic fracture)
What is the MC primary malignant bone tumor in children
osteosarcoma
What does osteosarcoma produce
osteoid
Tx for osteosarcoma
chemotherapy followed by surgical excision and post-op chemo
What is MC sarcoma to metastasize to LNs?
synovial sarcoma
What populatino does ewings affect most
kids and adolescents
3 MC soft tissue sarcomas of hands and feet
what is unique about these 3 sarcomas
Synovial sarcoma
Epitheliod sarcoma
Rhabdomyosarcoma
They all 3 can metastasize to LNs (no other sarcomas mets to LNs)
liposarcoma is defined as
a lipoma
Below the fascia
3 MC soft tissue tumors in general (and MC)
MC = MFH sarcoma (malignant fibrous histiocytoma) -
Liposarcoma
Synovial sarcoma
what level is elevated in osteosarcomas
ALP
what is MC site for sarcoma mets
lung
tx of ewings?
chemo, radio, surgery
Codman triangle is dx of what
osteosarcoma
greater than what % of necrosis (f the tumor) is considered “good response” to chemo?
> 90%
high ALP present in what 2 things
osteosarcoma and pagets
What can be seen in synovial sarcomas
calcifications
synovial sarcoma marker
cytokeratin
adipose nucleus scalloped by fat drops is a hallmark for what
liposarcomas
