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D&T test 6 - endocrine, dermatology, MSK > Path: Skin 2 > Flashcards

Path: Skin 2 Flashcards

1
Q

Primary feature of spongiotic dermatitis and it’s histological appearance

A

intraepidermal edema

Intercellular bridges between keratinocytes are visisble (dt edema)

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2
Q

What is the clinical term for spongiotic dermatitis? and what does it look like? and what is the prototype

A

Eczematous dermatitis: Red, papulovesicular, oozing, crusting
prototype: poison ivy = contact dermatitis

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3
Q

Histo features of spongiotic/eczematous dermatitis (2)

A

intraepidermal vesicles (dt edema)

lymphocytes in dermis

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4
Q

What is pathogenesis of spongiotic/eczematous contact dermatitis?

A

Dendritic Langerhans cells present antigen to Tcells in LNs. Rexposure = T cell cytokine release

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5
Q

What is the most important feature of Psoriasiform Dermatitis

A

Epidermal acanthosis (thickening)

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6
Q

What are psoriasis sufferers at higher risk for (2)

A

CVD=occlusive vascular disease

psoriatic arthritis

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7
Q

CP of psoriasis (2)

A

salmon pink plaque with silver scale

pitted, yellow nails

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8
Q

Histological features of paoriasis (3)

A

parakeratosiswith neutrophils (monroe’s microabscesses)
thin S. granulosum
thick S. spinosum

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9
Q

What special “sign” is seen in psoriasis and why

A

Auspitz sign: pinpoint bleeding with scrapin go keratin bc papillary dermis is so close to surface

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10
Q

What is 1st line therapy for psoriasis

A

Vitamin D3 topical lotion =

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11
Q

What enzyme and function does Vitamin D3 topical lotion act on in psoriasis

A

it activates transglutaminase (an enzyme important to proper epidermal proliferation)

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12
Q

Key feature of interface dermatitis

A

damage to basal layer (Histo pattern is same in all of these, CP differs)

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13
Q

What are the 2 types of interface dermatits?

A

Perivascular inflammation with basal vacuolization

Lichenoid pattern

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14
Q

What is CP of Erythema multiforme

A

targetoid lesion (central necrosis)

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15
Q

What is erythema multiforme due to and what is the MC cause?

A

due to HSR

HSV = MC

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16
Q

What differentiates Erythema multiforme from Stevens-Johnson Syndrome (3),

A

diff: Skin sloughs off in SJS, Mucous mbs are involved in SJS, fever

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17
Q

Define: Toxic Epidermal Necrolysis

A

10-30% skin involvement in SJS denotes TEN-SJS

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18
Q

What is MC cause of SJS

A

drugs

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19
Q

Subactute Lupus erythematosis CP?(2)

A
  1. blanchable erythema

2. no systemic involvement

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20
Q

Chronic Lupus erythematosis (discoid Lupus) CP?(3)

A
  1. no systemic involvement
  2. hair loss
  3. plaques with hyper and hypo-pigmentation
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21
Q

Histology of Lupus eryhtematous

A

Mucin deposition

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22
Q

IF of Lupus erythematous (what is deposited (2) and where)

A

Ig and complement at D/E jct

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23
Q

CP of Lichen planus (mnemonic) (2)

A

“P’s” =
1. pruritic, purple, polygonal, planar papules,

  1. oral mucosal involvement is common
24
Q

What is the name and appearance of the oral involvement in Lichen planus

A

Wickham Striae (white lines)

25
Histo hallmark of lichen planus
"sawtooth" basal layer with lymphocytes hugging the dermal-epidermal jct
26
What are the 3 categories of Bullous dermatoses?
Subcorneal, suprabasal (above SB), or subepidermal
27
Pathogenesis of Pemphigus Vulgaris
IgG antibodies target desmoglein 3 in desmosomes (desmososmes hold epithelial cells together) a type II HSR
28
CP of Pemphigus Vulgaris (including hallmark) (2)
fragile bullae (blisters don't hold very long = erosion looking) hallmark = Oral Mucosal involvement- erythematous mucosa
29
What "sign" is assc with Pemphigus Vulgaris and what is it
Nikolsky's sign = separation of epidermis with q-tip
30
Describe the microscopic appearance of Pemphigus Vulgaris blister (category)
suprabasilar blister with "tombstone" basal layer
31
Pemphigus Vulgaris is unique for what cell type in epidermis?
Eosinophils in SS
32
IF of Pemphigus Vulgaris:
IgG between keratinocytes (chicken wire or "fish-net" pattern
33
Bullous Pemphigoid pathogenesis
AIDz: IgG antibodies against hemidesmosome proteins
34
What do Hemidesmosomes bind?
epidermis to basement membrane
35
Which Category of bullous dermatoses is Bullous Pemphigoid 9mnemonic)
Subepidermal Split (BUllous = "bullow" the epidermis
36
gross difference between bullous Pemphigoid and Pemphigus Vulgaris
bullous Pemphigoid = durable blisters
37
What micro feature does bullous Pemphigoid share with Pemphigus Vulgaris
Blister contains eosinophils
38
IF of bullous pemphigoid
linear IgG along BM
39
CP of dermatitis herpetiformis
Pruritic (super itchy), burning,
40
What is dermatitis herpetiformis assc with
Associated with Celiac Disease -
41
Pathogenesis of dermatitis herpetiformis
IgA antibodies against basement membrane anchoring fibrils
42
tx for dermatitis herpetiformis
responds to gluten-free diet
43
IF of dermatitis herpetiformis
IgA deposits at tips of dermal papillae
44
What 3 things cause acne
1) Androgens 2) Propionibacterium acnes Follicular obstruction, drugs, occlusion
45
histo feature of dermatitis herpetiformis
neutrophilic abscesses
46
What is, and what is the prototype of Panniculitis?
Inflammation of subQ fat | Prototype = erythema nodosum
47
How does erythema nodosum present?
tender nodules on anteroir shins
48
What is erythema nodosum assc with (4)
a) Infx: B-hemolytic strep b) Drugs: OCPs, sulfonamides 3. Sarcoidosis 4. IBD
49
What layer do dermatophytes infect (be specific)
keratin layer (stratum corneum)
50
What is seen in hosto of dermatophyte (2)
hyphae and neutros in keratin
51
Molluscum contagiosum gross appearance
Dome-shaped papule with central crater
52
What are Molluscum bodies: and where?
pink cytoplasmic inclusion bodies in upper epidermis
53
Impetigo CP:
"honey-colored crusts"
54
impetigo 2 causes (and MC)
Staphylococcus (MC) or Streptococcus
55
Histo of impetigo (type of infiltrate)
Subcorneal pustule (neutrophil infiltrate) - inflamed infectious blister
56
which HSV causes oral and which genital
``` HSV-1 = oral HSV-2 = genital ```
57
4 M's of herpes:
1) Multinucleation 2) Megaly - big cells 3) Margination- chromatin around edge of nuclei 4) Moulding- two cells together

D&T test 6 - endocrine, dermatology, MSK (22 decks)

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