Path Eye Flashcards

- Compare and contrast acute vs. chronic glaucoma (open angle vs. closed angle) - Define the following degenerative conditions of the eye: Arcus Senilis, Pterygium, Pinguecula, Macular degeneration (wet vs. dry), Cataracts - Describe the pathologic manifestations of diabetic retinopathy. - List the common causes of central retinal artery and vein occlusion. - Describe the clinicopathologic features of 2 common tumors of the eye (melanoma and retinoblastoma) - Define chalazion

1
Q

Viruses that can cause conjunctivitis

A

adenovirus and Herpes simplex

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2
Q

bacteria that can cause conjunctivitis

A

Opthalmia noenaturum

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3
Q

neoplasms that can cause conjunctivitis

A

Squamus cell carcinoma, melanoma

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4
Q

small raised pale yellow-tan nodule, usually nasal

A

pinguecula

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5
Q

triangular vascularized growth onto cornea from nasal limbus

A

pterygium

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6
Q

most common type of glaucoma

A

open angle

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7
Q

glaucoma more common in blacks

A

open angle

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8
Q

cause of close angle glaucoma

A

physical obstruction of outflow tract by peripherial iris, causing increased intraocular pressure

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9
Q

sx of closed angle glaucoma

A

pain, redness,photophobia, decreased vision, fixed, mid-dilated pupil

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10
Q

what can trigger sx in closed angle glaucoma

A

being in a dark room for a long time

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11
Q

sx of open angle glaucoma

A

arcuate visual field loss

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12
Q

types of cataracts

A

nuclear, cortical, or subcapsular

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13
Q

causes of adult cataracts

A

sun exposure, diabetes, steroids

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14
Q

causes of congenital cataracts

A

rubella, CMV

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15
Q

vascular causes of retainopathy

A

diabetes, hypertension, vessel occulsion

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16
Q

worse form of macular degeneration

17
Q

most common cause of macular degeneration

18
Q

drusen on a thick, possibly calcified bruch’s membrane is..

A

dry macular degeneration

19
Q

subretinal choroidal neovascular membrane breaks through bruche’s membrane - causing hemorrage and scar

A

wet macular degeneration

20
Q

causes os optic disc edema

A

malignant hypertension, optic neuropathy, elevated ICP

21
Q

histopathologic signs of optic disc edema

A

elevation of optic disc, displacement of retina at disc margin, neerve fiber layer menorrhages at disc margin, cotton wool microinfarcts

22
Q

mutation causing retinoblastoma

A

RB gene on 13q14 (both alleles need be mutated)

23
Q

type of gene RB is

A

tumor suppressor

24
Q

clinical features of retinoblastoma

A

white pupil, strabismus

25
most common secondary tumor wound in germline retinoblastoma
osteosarcoma
26
histology of retinoblastoma
rosettes, fleurette, pseudorosette
27
adverse prognstic findings
invasion into choroid and/or optic nerve, extraocular extension, diffuse and/or growth anterior to equator
28
most common primary eye malignancy in adults
melanoma
29
histology of eye melanoma
spindle cells, epitheliloid cells, necrosis
30
adverse prognosis in eye melanoma
extraocular extension, large tumor, eppitheloid type, closed loop patterns, metastatses
31
most common sites of melamona mets
liver, lung, brain, bone, GI