patho book ch. 23 Flashcards
(23 cards)
adequate iron levels are crucial for effective
erythropoiesis and oxygen transport
unconjugated bilirubin is transported to where bound to albumin
liver
In the liver, bilirubin is conjugated with what, making it water-soluble
glucuronic acid
what happens to conjugated billirubin
it is excreted into bile, intestine, and feces
this is elevated in hemolytic anemia
reticulocyte percentage
a antigens b antibody
a
b antigens a antibodies
b
a and b antigens, no antibodies
ab
no a and b antigens, both a and b antibodies
o
if d antigen is on rbc
rh-positive
fever, chills, back pain, hypotension, hemoglobinuria
acute hemolytic reaction
mild fever, jaundice, decreased hemoglobin
dealayed hemolytic reaction
acute blood loss rbc characteristic
normocytic and normochromic
hereditary spherocytosis rbc characteristic
spherically shaped, increased fragility
sickle cell rbc characteristic
sickle shaped under low oxygen conditions
iron deficiency anemia rbc characteristic
microcytic, hypochromic
aplastic anemia rbc characteristic
reduced count with normal morphology
A myeloproliferative disorder with increased RBC production independent of erythropoietin; symptoms include headache, dizziness, and splenomegaly.
polycthemia
Elevated RBCs due to increased erythropoietin from chronic hypoxia or tumors; symptoms relate to underlying cause.
secondary polycythemia
has a higher affinity for oxygen, facilitating oxygen transfer from mother to fetus.
hemoglobin F
factors that predispose hyperbilirubinemia in infants
- Immature liver enzymes.
- Increased RBC turnover.
- Breastfeeding-associated jaundice.
- Hemolytic diseases.
- Genetic disorders affecting bilirubin metabolism.
lipid-soluble can cross blood brain barrier
unconjugated bilirubin
water soluble less likely to cause neurotoxicity
conjugated bilirubin
