Patho: Joints 2 RA Flashcards Preview

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Flashcards in Patho: Joints 2 RA Deck (5)
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1

RA define

is a chronic systemic inflammatory disorder that affects may tissues and organs including the joints, skin, blood vessels, heart and lungs and muscles

2

Joints are the principal thing attached what joints are affected?

• Diarthrotic joints symmetrically and bilaterally
• May progress first in one hand, than the other
• Proximal interphalangeal and metacarpophalangeal joints, elbows, knees, ankles, and spine

3

what would you expect the joint infiltrate to look like on aspiration?

Produces a nonsuppurative (not a WBC infectious process) proliferative and inflammatory synovitis – inflammation but if you drain, will not be purulent

4

RA will often progress to what?

Often progresses to destruction of the articular cartilage and ankylosis (fusion) of the joints (consolidation of bone). May not be able to close hand due to this.

5

what genetic factors influence RA?

HLA (human leukocyte antigen) proteins : HLA-DR4, DR1, DR10, DR14

Seropositive RA (poor prognosis): High frequency of arginine in the DR epitope

Seronegative RA (good prognosis)
High frequency of lysine in the DR epitope

PTPN22: Tyrosine phosphatase enzyme, when mutated activates inflammatory cells (T-cells)