Flashcards in Pharm: Random Topics: Emesis with chemo Deck (10):
1
Vomiting risk of chemo drugs
High:
Mod:
Low:
Min
•High: cisplatin, cyclophosphamide >1500
•Mod: -rubicin, cyclophaphamide <1500
•Low: -taxel, mitoxantrone, methotrexate
•Min: -tine, beva/rituximab
2
Serotonin (5HT) anatagonists
-
-
-
-
SE
• Ondansetron (zofran), dolasetron (anzemet), granisetron (granisol),
palonosetron (aloxi)-longest half life
SE: QT prolongation, correct hypo kalemia and magnesemia prior
3
Corticosteriods
dexamethasone, methylprenisolone (deop-medrol)
4
Neurokinin 1 receptor antagonist
Aprepitant (EMDEND) can pass thought the BBB to bind to Substance P and NK receptors, used to decreased N/V
5
DA receptor antagonist
drug:
SE:
• Metoclopramide (reglan)
• SE: extrapyridimal symptoms, sedation, restlessness, fatigue- doesn't use a lot due to se
6
➢ Phenothiazines
Phenothiazine: Blocks H1, not histamine
Peochlorperazine (compazine): Inhibits chemotrigger zone
just know its avb
7
➢Cannabiniods
•Dronabinol (marinol)
•Nabilone (cesamet)
8
➢Guideline Overview
➢Guideline Overview
9
Time of onset for N/V:
acute:
delayed:
anticipatory:
-Acute= initial 24hrs after chemo
-Delayed= later than 24hrs after chemo
-Anticipatory=days to hours before chemo
10