Pathogenesis 10/5/16

Question 1

Is IL-1B high or low in disease?

Answer 1

High

Question 2

Is IL-4 high or low in disease?

Answer 2

Low

Question 3

Is IL-10 high or low in disease?

Answer 3

Low

Question 4

Is TNF-a high or low in disease?

Answer 4

High

Question 5

IS IL-1ra high or low in diesease?

Answer 5

Low

Question 6

Is INF-g high or low in disease?

Answer 6

High

Question 7

Is PGE2 high or low in disease?

Answer 7

High

Question 8

Is MMPs high or low in disease?

Answer 8

High

Question 9

Is TGF-b high or low in disease?

Answer 9

Low

Question 10

Are TIMPs high or low in disease?

Answer 10

Low

Question 11

What type of cytokine do you find in GFC?

Answer 11

IL-1 alpha and beta

Question 12

What does IL-1 alpha and beta activate?

Answer 12

CD4

Question 13

What interleukin is secreted by CD4 and NK cells?

Answer 13

-IL-2 alpha and beta

Question 14

What interleukin enhances the production of IgA?

Answer 14

IL-5

Question 15

What cytokine activates osteoclasts leading to bone resorption?

Answer 15

TNF alpha and beta

Question 16

Is IL-1B proinflammatory or anti-inflammatory?

Answer 16

Proinflammatory

Question 17

Is TNF alpha proinflammatory or anti-inflammatory?

Answer 17

Proinflammatory

Question 18

Is TGF-b proinflammatory or anti-inflammatory?

Answer 18

Anti-Inflammatory

Question 19

Is IL-1ra proinflammatory or anti-inflammatory?

Answer 19

Anti-inflammatory

Question 20

Is IL-10 pro or anti inflammatory?

Answer 20

Anti

Question 21

Is IFN-gamma Pro or anti inflammatory?

Answer 21

Pro

Question 22

Is PGE2 pro or anti inflammatory?

Answer 22

Pro

Question 23

Is IL 4 pro or anti inflammatory?

Answer 23

Anti

Question 24

Are MMPs anti or pro inflammatory?

Answer 24

Pro

Question 25

Are TIMPs pro or anti inflammatory?

Answer 25

Anti

Question 26

Is anti or pro inflammatory protective?

Answer 26

Anti

Question 27

What is the primary proteinases involved in periodontal tissue degradation?

Answer 27

MMP

Question 28

What do MMPs degrade?

Answer 28

- collagen - gelatin - elastin

Question 29

What inhibits MMPs?

Answer 29

modified tetracycline

Question 30

What does arachidonic acid do to the vasopermeability and vasodilation?

Answer 30

Increases

Question 31

What does arachidonic acid do to MMP secretion by monocytes and fibroblasts?

Answer 31

Induces them

Question 32

T/F | Arachidonic Acid is not increased in gingivitis and periodontal disease

Answer 32

False | It is increased

Question 33

What breaks down arachidonic acid?

Answer 33

COX 1/2

Question 34

What type of people do you find high levels of arachidonic acid in?

Answer 34

Type II diabetics

Question 35

How do you inhibit PGE2 synthase from making PGE2?

Answer 35

NSAIDs

Question 36

What are three cytokines that can upregulate monocyte PGE2 secretion?

Answer 36

- TNF alpha - IL-1b - GM-CSF

Question 37

What systemic factors can lead to more periodontitis?

Answer 37

- Host stress - Physical stress - Social effectors - Environmental stress

Question 38

Host stress will release what neuropeptide?

Answer 38

Corticotropin releasing factor (CRF)

Question 39

When CRF is released what does that lead to the release of?

Answer 39

IL-1 | TNF-a

Question 40

What does TNF-1 and IL-1 lead to?

Answer 40

Periodontitis