Pathogenesis

Question 1

3 factors affecting pathogenesis

Answer 1

Pathogen
Host
Environment

Question 2

Infective dose of Coxiella (Q fever)

Answer 2

1

Question 3

Infective dose of shigella

Answer 3

10

Question 4

Infective dose of Salmonella

Answer 4

100-1000

Question 5

What is prodromal period?

Answer 5

When you feel disease coming

Question 6

3 acute disease

Answer 6

Measles
Mumps
Flu

Question 7

3 chronic diseases

Answer 7

TB
Leprosy
Syphilis

Question 8

What is an example of a subacute disease?

Answer 8

Bacterial endocarditis

Question 9

Is Gonorrhea symptomatic?

Answer 9

It’s symptomatic in males right away and in females months later

Question 10

Is Trichomoniasis symptomatic?

Answer 10

It’s only symptomatic in females (which makes it hard to tract contact for males)

Question 11

2 examples of latent diseases

Answer 11

Herpes & Chickenpox

Question 12

How long does it take for syphilis tertiary phase?

Answer 12

5-50 years

Question 13

How long does it take for syphilis secondary phase?

Answer 13

2-6 months

Question 14

Virulence factors (3)

Answer 14

Integrin (receptor)
Adhesion (ligand)
Pili (fimbriae)

Question 15

Adhesion & Receptor of GAS

Answer 15

Adhesion = Protein F
Receptor = fibronectin

Question 16

Adhesion & Receptor of HIV

Answer 16

Adhesion: gp120
Receptor: CD4

Question 17

What virulent factor is considered a colonization factor?

Answer 17

Fimbriae (pili)

Question 18

Obligate intracellular pathogens

Answer 18

Chlamydia
Rickettsia
Ehrlichia
(Sporozoan protozoa;)
Plasmodium
Bebesia

Question 19

2 Types of ehrlichia infections

Answer 19

Anaplasma (PMNL)
Ehrlichia (Monocyte)

Question 20

4 microbial mechanisms to escape host

Answer 20

Camouflage
Molecular mimicry
Antigenic variation
Destruction of antibodies

Question 21

Which microbe uses camouflage?

Answer 21

Schistosomes

Question 22

Which microbe uses molecular mimicry?

Answer 22

GAS > Hyaluronic acid capsule similar to humans
Mycoplasma pneumoniae > Makes cell fight own Ags

Question 23

Which microbe uses Antigenic variation?

Answer 23

Flu
HIV
Gonococcus
Borrelia
Trypanosomes (sleeping sick)

Question 24

Which microbe uses Destruction of Abs?

Answer 24

H. Flu
Gonococcus
Pneumococcus

Question 25

What does S. Aureus exoenzyme do ?

Answer 25

Coagulation

Question 26

Which bacteria use kinases?

Answer 26

Strep & Staph

Question 27

Which MOs produce Hyaluronidase exotoxin?

Answer 27

Strep , staph, Clostridium

Question 28

2 Necrotizing enzyme examples

Answer 28

Flesh eating GAS Clostridium

Question 29

Which 2 MOs produce neurotoxins?

Answer 29

Clostridium tetani (tetanus) Clostridium botulinum

Question 30

How does tetansospasmin work?

Answer 30

Inhibiting GABA release

Question 31

How does botulinal toxin work?

Answer 31

Block release of Ach

Question 32

Which MOs cause enterotoxin

Answer 32

Bacillus cereus C. Difficile Salmonella C. Perfringens Vibra cholerae (to) S. Aureus

Question 33

What does SSSS stand for

Answer 33

Staph Scalded skin syndrome

Question 34

What does STSS stand for?

Answer 34

Staph toxic shock syndrome

Question 35

Causes of STSS

Answer 35

Tampon Nasal packing Wounds

Question 36

What disease does GAS’s eythrogenic toxin cause?

Answer 36

Scarlet fever

Question 37

4 Potent exotoxins (sAg)

Answer 37

TSST-1 Enterotoxins (S. Aureus) Enterotoxin (C. Perfringes) Erythrogen toxin

Question 38

What is a superantigen?

Answer 38

Stimulates MHCII with very high potency and cause toxic shock

Question 39

What toxin causes septic shock?

Answer 39

G- endotoxin

Question 40

What toxin causes Toxic shock?

Answer 40

S. Aureus exotoxin

Question 41

4 exotoxins that inhibit protein synthesis?

Answer 41

C. Diphtheria Pseudomonas aeruginosa Shigella E. Coli

Question 42

What toxin does E. Coli release?

Answer 42

Shiga like toxin

Question 43

Only pathogenic fungi (yeast) with a capsule?

Answer 43

Cryptococcus neoformans

Question 44

5 G+ bacteria with capsule?

Answer 44

Pneumococcus S. Aureus/Epidermidis Strep. Pyogenes/Agalactiae

Question 45

What kind of capsule does GBS (S. Agalactiae) have?

Answer 45

Sialic acid

Question 46

Bacteria with polypeptide capsule

Answer 46

Bacillus anthracis