Pathology

Question 1

Proteins for leukocyte rolling

Answer 1

Leukocyte: Mucin-like CAM + Sialyl Lewis Glycosylation, L-selectin

ET: E selectin, P selectin, GlyCAM1, CD34

Question 2

Proteins for stable adhesion

Answer 2

Leukocyte: CD11/18 Integrins (LFA1, Mac1), VLA4 integrin

ET: ICAM1, VCAM1

Question 3

Proteins for diapedesis

Answer 3

Leukocytes and ET: PECAM1

Question 4

Proteins for chemotaxis through tissue

Answer 4

Chemotactic agents: C5a, IL8, LTB4, Kallikrein, Platelet activating factor

Question 5

BCR-ABL

Answer 5

CML

ALL

Question 6

BCL2

Answer 6

Follicular Lymphoma

Undifferentiated Lymphoma

Question 7

BRAF

Answer 7

Melanoma

NHL

Question 8

c-KIT

Answer 8

GIST

Question 9

c-Myc

Answer 9

Burkitt Lymphoma

Question 10

Her2/Neu

Answer 10

Breast
Ovarian
Gastric carcinomas

Question 11

L-myc

Answer 11

Lung cancer

Question 12

N-myc

Answer 12

Neuroblastoma

Question 13

RAS

Answer 13

colon cancer
lung cancer
pancreatic cancer

Question 14

RET

Answer 14

MEN2A, 2B

Medullary thyroid cancer

Question 15

APC

Answer 15

colorectal cancer (FAP)

Question 16

BRCA1,2

Answer 16

Breast cancer

ovarian cancer

Question 17

DCC

Answer 17

Colon Cancer

Question 18

DPC4/SMAD4

Answer 18

Pancreatic cancer

Question 19

MEN1

Answer 19

MEN1

Question 20

NF1

Answer 20

Neurofibromin/RAS GTPase-activating protein

Question 21

NF2

Answer 21

Merlin/Schwannomin protein

Question 22

p16

Answer 22

melanoma

p16 is CDK2a

Question 23

p53

Answer 23

most cancers
Li Fraumeni syndrome
(TF for p21, blocks G1 to S transition)

Question 24

PTEN

Answer 24

Breast cancer
prostate cancer
endometrial cancer

Question 25

Rb

Answer 25

retinoblastoma osteosarcoma (Inhibits E2F, blocks G1 to S transition)

Question 26

TSC1

Answer 26

hammartin in tuberous sclerosis

Question 27

TSC2

Answer 27

tuberin in tuberous sclerosis

Question 28

VHL

Answer 28

VHL disease renal cell carcinoma (VHL inhibits HIF1a)

Question 29

WT1,2

Answer 29

Nephroblastoma (wilm's tumor)