PATHOLOGY - Equine Urinary Disease Flashcards

(75 cards)

1
Q

Describe the appearance of normal urination in a male horse

A

When male horses urinate, they will be in a stretched, lordotic (inward curvature of the lumbar spine) position, the tail will be elevated and the penis will be out of the sheath. Urination in horses requires abdominal contraction, and there should be a brisk stream of urine which won’t contaminate their limbs due to their posturing. Male horses may grunt when urinating, this is normal and not a sign of pain

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2
Q

Describe the appearance of normal urination in a female horse

A

When female horses urinate, they will be in a stretched lordotic position, the tail will be elevated and there should be a brisk stream of urine which which won’t contaminate their limbs or perineum due to their posturing

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3
Q

How does urination differ in horses in oestrus?

A

When female horses are in oestrus, they will have pollakuria

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4
Q

How much water should a horse intake per day?

A

2 - 4 litres of water per kg of dry matter consumed per day

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5
Q

When is a horse classified as polydipsic?

A

A horse is classified as polydipsic if they are drinking more than 100ml/kg/day

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6
Q

What is one of the first signs of polydipsia in the horse?

A

Hard faeces

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7
Q

What are the differential diagnoses for PUPD in horses?

A

Psychogenic polydipsia
Secondary renal medullary washout
Hyperadrenocorticism
Chronic renal failure
Diabetes insipidus

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8
Q

What is the most common cause of PUPD in horses?

A

Psychogenic polydipsia

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9
Q

What causes psychogenic polydipsia in horses?

A

Psychogenic polydipsia is usually due to boredom, environmental changes or feeding changes in horses

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10
Q

What is secondary renal medullary washout?

A

Renal medullary washout is a condition where the normal osmotic gradients between the renal interstitium and the renal tubules are reduced due to a loss of sodium, resulting in an inability to concentrate urine. This loss of sodium can be caused by long term psychogenic polydipsia as excessive water intake will dilute sodium levels in the blood, and result in the loss of both water and sodium in the urine. Horses with renal medullary washout and psychogenic polydipsia usually concentrate their urine in response to the gradual restriction of water, achieved via a water deprivation test

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11
Q

What is the gross appearance of normal adult equine urine?

A

Normal adult equine urine will appear pale yellow to brown, slightly turbid and viscous

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12
Q

Why does normal adult equine urine appear turbid and viscous?

A

Horses have a large quanitity of mucus in their urinary tract which causes the urine to be viscous, and horses excrete a lot of calcium crystals into their urine due to their diet being so high in calcium, causing the urine to be turbid

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13
Q

When is urine specific gravity (USG) classified as hypersthenuric in an adult horse?

A

Urine specific gravity above 1.020 is classified as hypersthenuric

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14
Q

What is the gross appearance of normal foal urine?

A

Normal foal urine will appear yellow, watery and translucent

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15
Q

Why do foals typically have dilute urine?

A

Foals should typically have dilute urine as they have a higher intake of fluids, primarily milk, which is high in water content. As a result they should be producing dilute urine

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16
Q

What can be indicated if a foal produces more concentrated urine?

A

If a foal produces more concentrated urine, this can indicate they are not getting sufficient fluid intake

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17
Q

Which urinary tract diseases are seen in young horses?

A

Patent urachus
Ectopic ureters
Rectovaginal fistula
Rectourethral fistula
Polycystic kidney disease
Renal agenesis

Most of these are congenital diseases

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18
Q

What is the key sign of ectopic ureters in horses?

A

Urinary incontinence in a young horse can be a key sign of ectopic ureters

More common in fillies

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19
Q

Which urinary tract diseases are more commonly seen in older horses?

A

Neoplasia
Urolithiasis

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20
Q

What are the most common forms of bladder neoplasia seen in horses?

A

Bladder squamous cell carcinoma
Bladder transitional cell carcinoma

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21
Q

Which history questions can be benefial to ask when investigating equine urinary tract disease?

A

Have there been any recent dietary changes?
Has the horse been moved from pasture to stabling?
Is the forage the horse is being fed high in calcium?
Is the horse being given any supplements (such as calcium supplements)?
Is the water intake adequate?
Does the horse have access to salt blocks?
Has there been any recent environmental changes?
Has there been any recent trauma?
Are any of the other horses affected?
Could the horse have had access to any toxins?
Is the horse being treated with NSAIDS?

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22
Q

Why is it important to establish if the horse has had any recent dietary changes or has been moved from pasture to stabling?

A

Dietary changes and movement from pasture to stabling can cause a dramatic drop in water intake in horses (which could increase the risk of urolithiasis, and impaction if thinking in terms of colic)

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23
Q

Why is it important to determine the quantity of calcium in a horse’s diet?

A

Equine diets are already very high in calcium so it is important to determine if the owner has been providing high calcium forage or supplements as this could contribute to the development of further calcium carbonate crystals in the urine and increase the risk of urolithiasis

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24
Q

Which toxins can cause urinary tract disease in horses?

A

Red maple
Acorns
Aflatoxins

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25
What are the potential clinical signs of urinary tract disease in horses?
Dysuria Stranguria Pollakuria Haematuria Oliguria Anuria PUPD Urine scalding/staining of the hindlimbs or perineum Weight loss Lethargy Poor performance Pyrexia Anaemia Can appear lame due to external genital pain | More systemic clinical signs typically indicate renal disease
26
Which factors should you assess during the clinical exam of a horse with suspected urinary tract disease?
Thorough clinical examination Take a blood sample *(prior to sedation)* Rectal examination Collect a sterile urine sample Examine the external genitalia
27
Which structures should you palpate on rectal examination of the horse when investigating urinary tract disease?
Caudal aspect of the left kidney Bladder
28
How do you collect a sterile urine sample in horses?
Urinary catheterisation
29
Which sedative drugs should you use to examine the penis on a horse?
To examine the penis you should sedate the horse with a combination of acepromazine and xylazine as acepromazine is the most reliable sedative drug for relaxation of the retractor penis muscle
30
What are the differential diagnoses for a mass on the penile sheath in horses?
Sarcoid Squamous cell carcinoma Habronemiasis Melanoma
31
Which signalement is more prone to melanoma in horses?
Grey horses are more prone to melanoma due to having increased numbers of melanocytes
32
What are the differential diagnoses for a perineal or perivulval mass in female horses?
Squamous cell carcinoma Abscess Post-service injury Fibrosarcoma Lymphoma
33
What is indicated by depigmentation of the external genitalia in horses?
Depigmentation of the external genitalia in horses can be a key sign of papilloma virus lesions which can precede the development of squamous cell carcinomas
34
What is a urethral diverticular concretion?
A urethral diverticular concretion, also known as a bean, is an accumulation of excess smegma which has hardened at the urethral fossa in male horses
35
What are the clinical signs of a urethral diverticular concretion?
Urine spraying Dysuria Swelling of the urethral opening
36
How do you treat a urethral diverticular concretion?
Manual removal of the bean and sheath cleaning with water based lubricant and water
37
Which diagnostic tests can be done when investigating urinary tract disease in the horse?
Urinalysis Haematology and Biochemistry Ultrasound Cystoscopy Abdominocentesis Neurological examination
38
What are the limitations of urine dipsticks in horses?
Urine dipsticks have a very low specificity in horses as they cannot distinguish between blood, haemaglobin, myoglobin and certain plant proteins that can be passed into the urine in horses
39
How do you assess the urine in horses?
Cytology
40
What is a more reliable method than can be used to measure proteins levels in the urine in horses?
Urine protein:creatinine ratio (UP:C)
41
Which crystals are normal to see in equine urine?
Calcium carbonate Calcium oxalate Triple phosphate
42
What are the most common causes of pre-renal azotaemia in horses?
Dehydration Hypovolaemia Endotoxaemia
43
What are the most common causes of renal azotaemia in horses?
Progression from pre-renal azotaemia NSAIDs Aminoglycosides
44
What is the most common cause of post-renal azotaemia in horses?
Urinary tract obstruction
45
How do the serum electrolytes change in horses with urinary tract obstructions?
Hyperkalaemia Hyponatraemia Hypochloraemia
46
What can cystoscopy be used to assess in horses?
Trauma Cystoliths Visualise the ureters Neoplasia
47
What is the typical signalement for urolithiasis in horses?
Middle-aged, male horses
48
What are some of the key clinical signs of urolithiasis in horses?
Dysuria Stranguria Haematuria after exercise Haematuria at the end of urination Urine scalding Colic signs
49
How can you diagnose urolithiasis in horses?
Rectal palpation Urinalysis and culture Ultrasound Cystoscopy
50
Why should you do a urine culture on patients that you suspect have urolithiasis?
Urolithiasis can predispose patients to urinary tract infections
51
How can you treat urolithiasis in horses?
Laprocystotomy Lithotripsy Direct removal via the external urethral orifice in mares Perineal urethrostomy
52
When is urolithiasis classfied as a surgical emergency?
Urolithiasis of the urethra is a surgical emergency due to urethral obstruction and may require referral
53
How can you medically manage urolithiasis in horses?
Restrict calcium intake Maximise water intake Diet with low cation to anion balance (DCAB) *(grain ration)*
54
What is sabulous urolithiasis in horses?
Sabulous urolithiasis refers to a condition where the bladder becomes filled with sandy or gravel-like sediment which can be made up of mineral particles or small uroliths
55
How can you treat sabulous urolithiasis in horses?
Bladder lavage with sterile saline Bethanechol Phenoxybenzamine
56
What are the benefits of bethanecol to treat sabulous urolithiasis in horses?
Bethanecol will increase detrusor contractility to try and excrete the sediment from the bladder
57
What are the benefits of pheonxybenzamine to treat sabulous urolithiasis in horses?
Phenoxybenzamine decreases internal urethral sphincter tone which can help to excrete the sedminent from the bladder
58
Why is cystitis more common in mares?
Mares have a shorter urethra compared to male horses which can make it easier for bacteria to enter the urinary tract and cause cystitis. Furthermore, mares that have birthed foals are more prone to cystitis due to the altered conformation of the urogenital tract relative to the anal sphincter, which can make it easier for ascending infections to reach the urogenital tract
59
How do you treat cystitis in horses?
Treat with antibiotics, ideally based on culture and sensitivity
60
Which antibiotics can you use to treat cystitis in horses when you don't have culture and sensitivity results?
Trimethroprim-sulphonamides (TMPS) Penicllin
61
What is the typical signalement for bladder rupture in horses?
Post-partum mares Male foals
62
What are the clinical signs of bladder rupture in horses?
Lethargy Inappetence Passage of small volumes of urine Pendulous abdomen
63
How can a bladder rupture present on biochemistry?
Azotaemia Hyperkalaemia Hyponatraemia Hypochloraemia
64
What can be done to assess if a horse has a uroabdomen secondary to bladder rupture?
Abdominocentesis and compare the effusion creatinine levels to the serum creatinine levels
65
What are the benefits of cystoscopy to diagnose a bladder rupture?
Cystoscopy can be used to determine the extent of the rupture and thus give a prognosis
66
How do you treat bladder ruptures?
Stabilse electrolyte imbalances Surgical correction Allow to heal by second intention
67
What are the congenital causes of urinary incontinence in horses?
Ectopic ureters Hydroureters
68
What are hydroureters in horses?
Congenital malformations can predispose horses to hydroureters which is where the ureters become abnormally enlarged or dilated
69
What are the neurological causes of urinary incontinence in horses?
Cauda equina syndrome Trauma to the spinal cord or brain
70
What is renal tubular acidosis in horses?
Renal tubular acidosis in horses is where the kidneys are unable to regulate the body's acid base balance, resulting in metabolic acidosis
71
What is type 1 renal tubular acidosis?
Type 1 renal tubular acidosis is where there is an inability to excrete H+ ions at the distal convoluted tubule
72
What is type 2 renal tubular acidosis?
Type 2 renal tubular acidosis is where there is an inability to reabsorb bicarbonate at the proximal convoluted tubule
73
What are the clinical signs of renal tubular acidosis in horses?
Lethargy Muscle weakness Ataxia Decreased body condition score Tachypnoea Tachycardia
74
How does renal tubular acidosis typically present on biochemistry and venous blood gas analysis?
Hyperchloraemia Hypokalaemia Metabolic acidosis
75
How do you treat renal tubular acidosis?
Correct the bicarbonate deficit and provide long term oral supplementation of bicarbinate based on venous blood gas analysis and response to treatment