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Flashcards in Pathology Final Exam Material Deck (134)
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1

Copper is a component of __________ and deficiency may result in reduced pigmentation

Copper is a component of tyrosinase and deficiency may result in reduced pigmentation

2

What is sebaceous adenitis?

Inflammatory reaction that targets sebaceous glands

mostly a disease of dogs (rare in cats and horses)

3

T/F: Hypercalcemia due to osteolysis by skeletal metastases is not a paraneoplastic syndrome

True

3

What is the proposed target for autoantibody binding in the case of Pemphigus Vulgaris?

Desmoglein III

Proposed pathogenesis: autoantibodies bind to desmoglein III → keratinocytes release proteases → adhesion proteins lost → acantholysis → suprabasilar vesicles and bullae 

3

Ventral deviation of the vertebral column is referred to as:

Lordosis

"boobs out"

3

T/F: Chondrosarcomas account for ~10% of primary bone tumors in the dog, and usually affect long bones more often than flat bones

False

Chondrosarcomas DO account for ~10% of primary bone tumors in the dog, but they usually affect flat bones (ribs, nasal turbinates, pelvis) more often than long bones

4

Decreased pigment of the hair is referred to as:

Leukotrichia

5

Sarcoidare locally aggressive, non-metastatic fibroblastic skin tumors primarily of which species? What age?

Typically in young horses, 3-6 years of age

Caused by BPV types 1 and 2

6

The superficial dermatitis that occurs on opposed skin surfaces, such as the folds on this dogs face, is referred to as:

Intertrigo (skin fold dermatitis)

6

the fracturing of trabeculae without external deformation of cortical bone is termed:

Microfracture/infraction

7

An increase in the number of cells in the stratum spinosum is referred to as:

acanthosis

acanthosis is a diffuse epidermal hyperplasia (thickening of the skin)

7

T/F: Fibrosis is a sign of acute inflammation.

False.

Fibrin deposition may be seen in acute inflammation. Fibrosis is an indication of chronic inflammation

8

Group of diseases clinically characterized by vesicles or bullae and acantholysis:

Pemphigus

8

__________ is defined as the inability of skeletal muscle fibers to relax, resulting in spasmodic contraction 

Myotonia

10

Most common cause(s) of Hepatogenous photosensitization

Lantana camara and mycotoxins (sporidesmin)

11

Decreased pigment of the skin is referred to as:

Leukoderma

11

The causative agent of exudative epidermitis of pigs is:

Staphylococcus hyicus

11

What is the bacterial agent responsible for Wooden Tongue in cattle?

Actinobacillus ligniersii

Produces pyogranulomatous lesions in soft tissue

11

T/F: A carcinoma-in-situ refers to a cancer within an epithelial surface that has penetrated the basement- membrane

FALSE

A carcinoma-in-situ refers to a cancer within an epithelial surface that has not penetrated the basement- membrane

12

This thick, hard, hairless plaque was found on the elbow of a kennel dog. What would be your diagnosis?

callus

It's a callus

12

Eosinophilic plaques are common lesions of the skin of which species?

Cats

(usually seen on the abdomen and medial thigh)

13

"Rubber Jaw," shown in the image, is commonly seen associated with:

2° Renal Hyperparathyroidism

Bones (especially those of the head) become swollen and are firm rather than hard; maxilla and mandible are usually affected; the mandibles may become quite pliable (rubber jaw)

14

Histamine is present in tissues, basophils, and platelets, but primarily in ____________

mast cells

16

Dermatophilosis affects a variety of domestic animal species. What is the causative agent?

Dermatophilus congolensis

16

T/F: Osteomalacia is a disease affecting young growing animals

False

Osteomalacia is a disease of grown (adult) animals (closed growth plate) - similar pathogenesis to rickets

Failure in the mineralization of osteoid primarily due to Vitamin D or Phosphorous deficiency

16

Inflammation of a joint resulting in fixation (lack of mobility) of a joint is termed:

ankylosis

16

Are bone neoplasias more commonly seen in dogs or cats?

Dogs

Primarily observed in dogs; to a lesser extent cats. Pretty rare in other animals

17

What a cute Landrace pig. But wait, what's that?! You notice erythematous papules and plaques and hoof malformation!

What should be on the top of your mind?

Dermatosis Vegetans 

inherited disorder of young Landrace pigs characterized by erythematous papules and plaques and hoof malformation, or giant cell pneumonia (fatal route)

18

UV light induces formation of which carcinogen from natural sterols in un-pigmented skin? 

cholesterol alpha oxide

UV light induces formation of a carcinogen (cholesterol alpha oxide) from natural sterols in un-pigmented skin

19

Failure of stratified squamous epithelium of skin, adnexa, and/or oral mucosa to develop completely is referred to as:

Epitheilogenesis Imperfecta (Aplasia cutis) 

Sharply demarcated areas devoid of the epidermis or mucosa exposing the underlying dermis or submucosa