Pathology - Pancreas Flashcards
(23 cards)
Most common anomaly of the pancreas?
Pancreas Divisum - main pancreatic duct drains to the minor papillae
Gene responsible for pancreatic agenesis?
PDX1
Most common cause of acute pancreatitis in males and females?
Males: toxin exposure
Females: gallstones
What clinical signs might be present in acute pancreatitis?
Cullen and Gray Turner signs
What are the three main concepts that lead to acute pancreatitis?
Duct obstruction
Acinar cell injury
Defective intracellular transport
Which preventable childhoood disease can cause acute pancreatitis?
Mumps
Gene mutations ini acute pancreatitis?
PRSS1, SPINK1, CFTR
Where does pain referred to for acute pancreatitis?
Left shoulder and upper back
Lab values for acute pancreatitis:
plasma amylase +
plasma lipase +
Major difference between acute pancreatitis and chronic pancreatitis?
Acute is reversible
Chronic is irreversible
Typical patient in chronic pancreatitis?
Middle-aged alcoholic male
Can also be CF in kids though
How can you diagnose autoimmune pancreatitis?
IgG4+ plasma cells found inside the pancreas
responds well to steroids
Lab values for chronic pancreatitis:
Alk phos +
Albumin –
NO increase in amylase/lipase
Patient presents after being stabbed, symptoms of acute pancreatitis. May have history of CF or alcoholism.
Pancreatic pseudocyst
Morphology of a pancreatic pseudocyst?
Localized clumps of necrotic/hemorrhagic cells
NO epithelial lining
Associated conditions with congenital pancreatic cysts?
AD-PKCD and VHL
Which pancreatic neoplasm is located in the head of the pancreas?
IPMNs
Most common mutations in pancreatic adenocarcinoma?
KRAS ad CDKN2A
Thin, old lady comes in with new onset diabetes. Diagnosis?
Pancreatic cancer - diabetes may be the first symptom!
Most common location for pancreatic cancer?
Head of the pancreas
Possible clinical presentation of pancreatic cancer?
Characteristic, painless jaundice, abdominal pain, cachexia, Trousseau’s sign
Lab testing done for pancreatic cancer:
CA19-9+
Carcinoembryonic antigen +
Elderly woman presents with painless jaundice and elevated alk phos- diagnosis?
Pancreatic cancer
