PD Drugs Flashcards
(14 cards)
discuss levodopa
immediate precursor of dopamine
peripheral dopamine cant cross BBB kaya need ng precursor
pass BB –> decarboxylated to dopamine = effect
oral, inhalation and IV
side effects of levodopa
nausea
dizzy
HA
somnolence
OH
older pt: confusion, hallucination, delusion, psychosis and agitation
effects of abrupt withdrawal of levodopa
neuroleptic malignant syndrome
- high fever
- involuntary movements
- muscle rigidity
discuss carbidopa
ldopa can be converted to dopamine in the periphery - not good since usto natin sa brain pa
inhibs dopa decarboxylase = di ma convert sa periphery
side effects of carbidopa
agitation
allergic reax
anxiety
blurred vision
confusion
constipation
darkening of urine and sweat
dec appetite
discuss MAO-B inhibitors
inhibs metabolism of dopamine to DOPAC
DOPAC - metabolite and usto natin di maconvert para madaming dopamine
selegiline and rasagiline
side effects of MAO-B inhibitors
nausea
dry mouth
light headedness
constipation
discuss COMT inhibitors
inhibits metabolism of dopamine to 3-methoxytyramine
entacapone
side effects of COMT inhibitors
dyskinesia
nausea
vomiting
OH
sleep disorders
hallucination
discuss dopamine agonists
inc binding of dopamine in synaptic cleft and mimic dopamine - to inc dop cellular level
bromocriptine
pramipexole
ropinirole
side effects of dopamine agonists
nausea
vomiting
OH
HA
dizzy
cardiac arrythmias
discuss amantadine
blocks domapine reuptake mechanism - inc dopamine in synapse
side effects of amantadine
OH
syncope
peripheral edema
dizziness
delusions
hallucinations
falls
xerostomia
constipaton
discuss deep brain stim
planting electeodes in the brain c neurostimulator
surgical procedure - invasive
if pt are not responsive to usual pharmacological mx
