PED pharm

Question 1

what pregnancy category is no risk evident

Answer 1

B

-note “A” is just no risk

Question 2

what pregnancy risk cannot be excluded

Answer 2

C

Question 3

what prego category is warfarin fall under

Answer 3

X (contr-indicated)

Question 4

what does Warfarin block which can cause teratogenic effects, fetal hemorrhage, and fetal death

Answer 4

Blood clotting factors (2,7,9,10)

Question 5

Is postpartum warfarin is useful and safe

Answer 5

yes

Question 6

what drug will you give to HELLP and/or pre-eclampsia bc these things are life threatening

Answer 6

corticosteriods

-specifically 9-fluoro-corticosteroids

Question 7

what is the last organ system to mature sufficiently to support extrauterine life

Answer 7

lungs

Question 8

what is used to treat RDS, neonatal death, and ventricular hemorrhage

Answer 8

corticosteroids

Question 9

When is antenatal corticosteriods indicated when a women as either the following; threatened pre-term labour, antepartum hemorrhage, preterm rupture of membranes, or conditions requiring c-section (pre-eclampsia, HELLP

Answer 9

women btw 24 and 34 weeks of gestation

-note his wave suffered from Pre-eclampsia and son needed the roids

Question 10

what is the drug of choice for fetal lung development

Answer 10

two doses of betamethasone 12 mg, i.m. 24 hours apart

Question 11

what is the path of corticosteroid mechanism of action

Answer 11

1) GCR binding 2) dissociation 3) dimerization 4) translocation

Question 12

Single course of this medication has no significant maternal or fetal adverse effects. But multiple courses for (~7 days) risk side effects

Answer 12

betamethasone or dexamethasone

Question 13

what are some contraindications for antenatal corticosteriods

Answer 13

mother w/ systemic infection, TB

-bc immunosuppression

Question 14

why dont we just give cortisol to the fetus

Answer 14

placenta metabolizes (inactivates) cortisol

• pacenta is rich in 11beta-hydroxy steroid dehydrogenase-2 (11B-HSD-2)
• fetus will be exposed to cortisone

Question 15

what drug class is used in pre-term delivery

Answer 15

Tocolytic agents

-relax uterine smooth muschle

Question 16

which tocolytic is a B-2 adrenergic receptor relaxes uterine smooth muscle

Answer 16

Terbutaline and Ritodrine

Question 17

Very useful to delay delivery for 24-48 hours, which allows time for a concurrent course of corticosteriods to act in a pre-term birth (24-32 weeks)

Answer 17

MgSO4

Question 18

what tocolytic drug is a COX inhibitor which blocks uterine PGF2alpha formation

Answer 18

Indomethacin

Question 19

what tocolytic drug is a Ca channel which relaxes uterine smooth muscle

Answer 19

Nifedipine

Question 20

which tocolytic drug has an adverse effect of acute onset pulmonary edema

Answer 20

Terbutaline and Ritodrine

Question 21

which tocolytic drug is contraindicated in maternal platelet dysfunction or bleeding disorder, hepatic dys, GI ulcers, renal dys, or asthma

Answer 21

Indomethacin

Question 22

Tocolytic drug who has an adverse effect of hypotension, reflex tachycardia

Answer 22

Nifedipine

Question 23

which drug is contraindicated in myasthenia gravis

Answer 23

MgSO4

Question 24

what drug used in the third trimester can cause maternal complications include prolongation of labor, postpartum hemorrhage, and gastric irritation

Answer 24

NSAID

Question 25

what drug used in third trimester has fetal adverse effects ranging from oligohydramnios and intrauterine closure of the ductus arteriosus to persistent pulmonary hypertension and fetal death

Answer 25

NSAID

Question 26

Drug that maintains a PDA

Answer 26

PGE1 (alprostadil) | -note to close PDA use indomethacin which inhbits PGE2

Question 27

what is indomethacin not effective in closing PDA

Answer 27

PDA in a full term baby | -used in premature infants

Question 28

what are some complications seen in PGE1 (alprostadil)

Answer 28

hypotension, tachycardia, apnea

Question 29

what is a good proxy of GFR

Answer 29

urine output

Question 30

what drug can cause neonatal encephalopathy due to bilirubin displacement and poor bilirubin clearance

Answer 30

Sulfonamides cause kernicterus

Question 31

what phase II enzyme which is responsible for hepatic ontongeny can cause gray baby syndrome

Answer 31

impaired glucuronidation in neonates | -the drug used is chloramphenicol

Question 32

what displaces bilirubin from albumin

Answer 32

SMX

Question 33

what pregnancy category are fluoroquinolones and trimethoprim

Answer 33

Pregnancy C | -birth defect risk

Question 34

what prego category do we see tetracyclines

Answer 34

Prego D | -see fatty liver, hepatotoxicity, stains teeth

Question 35

Do not admister age <18. Bc they cause cartilage erosion

Answer 35

Fluroquinolones

Question 36

Do not administer age < 8. Bc see bone, and teeth deposits

Answer 36

Tetracyclines

Question 37

what should we avoid to treat a fever & pain associated w/ viral illnesses. peak provalence is ~6 yrs of age

Answer 37

avoid aspirin. give acteminophen instead