peptic ulcer disease

Question 1

describe the pathophysiology of peptic ulcer disease

Answer 1

1 Depends on cause :
- Reduction in protective prostaglandins or
Increase in gastric acid secretions
2 Acidic contents of stomach/duodenum
break down mucosa
3 Pain varies with acid level affecting
area of ulcer

Question 1

define peptic ulcer disease

Answer 1

A break in the epithelial cells which penetrate down to the muscularis mucosa of either the stomach or duodenum

Question 2

what are the complications of peptic ulcer disease?

Answer 2

upper GI bleed
- gastric ( less common)
- duodenal ( more common)

Question 3

where do gastric peptic ulcers occur?

Answer 3

mostly at lesser curve

Question 4

how common are gastric peptic ulcers?

Answer 4

less common

Question 5

what are the causes of both gastric and duodenal peptic ulcers?

Answer 5

• H pylori
• NSAIDS
• Zollinger Ellison syndrome
• increased gastric acid
• bile reflux

Question 6

where do duodenal peptic ulcers occur?

Answer 6

mostly at D1/D2 ( duodenum 1/2) posterior wall

Question 6

how common are duodenal peptic ulcers?

Answer 6

more common 2-3 x more

Question 7

what are the symptoms of gastric peptic ulcers?

Answer 7

-Weight LOSS
-Nausea
-Heartburn
- epigastric pain- worse on eating
- better between meals + with antacids

Question 8

what are the symptoms of duodenal peptic ulcers?

Answer 8

• weight GAIN
• nausea
• heartburn
• epigastric pain worse between meals
• better with food

Question 9

how do you diagnose peptic ulcers?- if no red flags

Answer 9

if no red flags
- non invasive tests
— C Urea breath
—- stool antigen test

Question 10

how do you diagnose peptic ulcers?- if red flags

Answer 10

if red flags
- endoscopy + biopsy —> will show brunners gland hypertrophy

Question 11

how are peptic ulcers treated?

Answer 11

-stop NSAIDs
- If H pylori +ve
– triple therapy CAP antibiotics
- stop smoking
- potion pump inhibitors