PeriOp Flashcards

Question

Analysis of variance (ANOVA) is a statistical test to determine: a) The validity between an expected and observed outcome in a population b) The difference between the means of more than two populations c) The difference between two populations with non-parametric data d) The degree of similarity of the median between two or more populations e) If the variance within a population is likely to be abnormally or normally distributed

Answer 1

REPEAT B) analyse the difference between the means of more than two groups

Answer 2

AT Repeat Can occur in healthy young people The third heart sound is mainly created by the early-diastolic rapid distension of the left ventricle that accompanies rapid ventricular filling and abrupt deceleration of the atrioventricular blood flow S3 may be normal in people under 40 years of age and some trained athletes but should disappear before middle age. Re-emergence of this sound late in life is abnormal[5] and may indicate serious problems such as heart failure. 'Sounds like Ken-tu-cky'

Answer 3

REPEAT a) Critical appraisal PICO is a mnemonic used to describe the four elements of a good clinical foreground question: P = Population/Patient/Problem - How would I describe the problem or a group of patients similar to mine? I = Intervention - What main intervention, prognostic factor or exposure am I considering? C = Comparison - Is there an alternative to compare with the intervention? O = Outcome - What do I hope to accomplish, measure, improve or affect?

Answer 4

VICTORIA Am I missing something? I can't see total occlusion of anything here. Wellens syndrome- Lad

Answer 5

Victoria Screenshot sent to JJ B

Answer 6

REPEAT b. Unstable angina UTD: Unstable angina (UA) and acute non-ST elevation myocardial infarction (NSTEMI) differ primarily in whether the ischemia is severe enough to cause sufficient myocardial damage to release detectable quantities of a marker of myocardial injury (troponins): ●UA is considered to be present in patients with ischemic symptoms suggestive of an ACS and no elevation in troponins, with or without electrocardiogram changes indicative of ischemia (eg, ST segment depression or transient elevation or new T wave inversion). ●NSTEMI is considered to be present in patients having the same manifestations as those in UA, but in whom an elevation in troponins is present. MINS: Myocardial injury after non-cardiac surgery (up to 30 days post-op): 1. Elevated postop troponin 2. Resulting from myocardial ischaemia (i.e. no evidence of a non-ischaemic aetiology), not requiring an ischaemic feature (i.e. no chest pain, no ECG change) VISION studies (Vascular Events in Noncardiac Surgery Patients Cohort Evaluation) demonstrated that severity of MINS strongly associated with 30-day mortality after NCS. hs-cTnT <20ng/L ~ 0.5% 30 day mortality 20-64ng/L ~3% 30 day mortality 65-999 ng/L ~9% 30 day mortality >1000ng/L ~30% 30 day mortality Whilst VISION trial identified MINS in at risk patients, the question now becomes what interventions are available to prevent this complication?

Answer 7

REPEAT B) 02 consumptiom at rest One metabolic equivalent (MET) is the amount of oxygen consumed while sitting at rest, equal to 3.5 mL O2 per kg body weight × min

Answer 8

? Normal Can only find absolute numbers or according to BSA not weight per se Image https://thoracickey.com/cardiac-chambers/ PSAX End diastolic AREA: Hypovolemia <8cm2 Normal 8-14cm 2 Hypervolemia > 14cm2 IVSd and IVSs – Interventricular septal end diastole and end systole. The normal range is 0.6-1.1 cm. LVIDd and LVIDs – Left ventricular internal diameter end diastole and end systole. The normal range for LVIDd is 3.5-5.6 cm, and the normal range for LVIDs is 2.0-4.0 cm. LVPWd and LVPWs – Left ventricular posterior wall end diastole and end systole. The normal range is 0.6-1.1 cm. RVDd – Right ventricular end diastole. The normal range is 0.7-2.3 cm. Ao Root Diam – Aortic root diameter. The normal range is 2.0-4.0 cm. LA Diameter – Left atrium diameter. The normal range is 2.0-4.0 cm. The IVSd and IVPWd measurements are used to determine left ventricular hypertrophy, which is the thickening of the muscle of the left ventricle. LV hypertrophy is a marker for heart disease. In general, a measurement of 1.1-1.3 cm indicates mild hypertrophy, 1.4-1.6 cm indicates moderate hypertrophy, and 1.7 cm or more indicates severe hypertrophy. Hypovolaemia Normal for end diastole is 3.5 to 5.6cm

Answer 9

d. Severe liver failure but could also be e. Sepsis LIFTL: INTERPRETATION High SvO2 - increased O2 delivery (increased FiO2, hyperoxia, hyperbaric oxygen) - decreased O2 demand (hypothermia, anaesthesia, neuromuscular blockade) - high flow states: sepsis, hyperthyroidism, severe liver disease Low SvO2 - decreased O2 delivery: 1. decreased Hb (anaemia, haemorrhage, dilution) 2. decreased SaO2 (hypoxaemia) 3. decreased Q (any form of shock, arrhythmia) - increased O2 demand (hyperthermia, shivering, pain, seizures) - Causes of High SvO2 despite evidence of End-organ Hypoxia: 1. microvascular shunting (e.g. sepsis) 2. histotoxic hypoxia (e.g. cyanide poisoning) 3. abnormalities in distribution of blood flow Anesthesia Monitoring Of Mixed Venous Saturation: https://www.ncbi.nlm.nih.gov/books/NBK539835/ In sepsis, ScvO2 less than 70% or SvO2 lower than 65% correlate with poor prognosis.[2] In application, certain studies have shown that maintaining a goal ScvO2 greater than 70% leads to reduced mortality.[11] Therefore, ScvO2 is used to guide treatment algorithms in the Surviving Sepsis Campaign (SSC). Studies have shown that normal to higher levels of mixed venous oxygen saturation in patients with clinically worsening sepsis do not rule out tissue hypoxia due to the inability to utilize O2.[11][7] Therefore, several studies support the conclusion that abnormally low or high ScvO2 correlates with higher mortality in patients with septic shock.

Answer 10

IV hydration Fluid first (hartmanns or saline w k+) then insulin BJA Developments in the management of diabetic ketoacidosis 2015 Diabetic ketoacidosis (DKA) is a medical emergency and bedside capillary ketone testing allows timely diagnosis and identification of successful treatment. >0.9% saline with premixed potassium chloride should be the main resuscitation fluid on the general wards and in theatre; this is because it complies with National Patient Safety Agency recommendations on the administration of potassium chloride. >Weight-based fixed rate i.v. insulin infusion (FRIII) is now recommended rather than a variable rate i.v. insulin infusion (VRIII). >The blood glucose must be kept above 14 mmol litre−1 with the FRIII. >Precipitating factor(s) needs to be identified and treated. Surgery and also critical care may be indicated to manage the patient presenting with DKA.

Answer 11

b. sinus tachy with BBB The most correct answer would be Trifasicular block: RBBB with LAD (RBBB with left anterior hemiblock) and 1st degree heart block Barash 8E 2017: The term bifascicular block often refers to block in the right bundle and one of the two major fascicles of the left bundle. RBBB with left anterior hemiblock is present when the ECG shows an RBBB with a left axis deviation (usually greater than −60 degrees) in the absence of an inferior myocardial infarction. Complete RBBB with right axis deviation (greater than 90 degrees) is indicative of RBBB and left posterior hemiblock in the absence of a lateral myocardial infarction or evidence of right-sided heart failure. The term trifascicular block is used to describe first-degree AV block in the presence of bifascicular block. Is it necessary to insert a temporary pacemaker before general anesthesia for an asymptomatic patient with bifascicular or trifascicular block? The risk for progression to complete heart block in asymptomatic patients with bifascicular block is low. Further, no clinical characteristics have been identified that accurately predict the risk of development of complete heart block. Therefore, routine PPM implantation in patients with asymptomatic bifascicular block is not recommended. Observations made in the perioperative period have suggested that development of complete heart block during general anesthesia is also rare; therefore, it is generally not recommended that patients undergo temporary pacemaker insertion before general anesthesia. However, it is advisable to have an external pacemaker available in the operating room.

Answer 12

c) droplet precautions https://www.safetyandquality.gov.au/sites/default/files/migrated/Recommendations-for-the-control-of-Carbapenemase-producing-Enterobacteriaceae.pdf

Answer 13

a. Normal - Normal A normal or high oximetry reading should be disregarded because saturation monitors cannot differentiate between carboxyhaemoglobin and oxyhaemoglobin, owing to their similar absorbances. The blood gas PO2 will also be normal in these cases (despite the presence of tissue hypoxia). ## Footnote file:///Users/newuser/Downloads/BTS%20Guideline%20for%20oxygen%20use%20in%20adults%20in%20healthcare%20and%20emergency%20settings.pdf

Answer 14

c. Ischemic optic neuropathy Cardiac: Anterior Spinal: Posterior ION

Answer 15

a) Autonomy - Obligation to respect the decision-making capacities of persons. Non-maleficence: Obligation to avoid causing harm - If refused to proceed. Paternalism: A set of attitudes and practices in which the health provider determines that a patient's wishes or choices should not be honored. - If transfused patient against their wishes Beneficence: Obligation to provide benefits and to balance benefits against risks; obligation of physician to act for the benefit of the patient - Controversial interpretation in this case. Both proceeding and refusing to do case may be acting for the benefit of the patient, depending on how you look at the scenario. BJA: ‘MORAL balance’ decision-making in critical care https://www.bjaed.org/article/S2058-5349(18)30145-8/fulltext

Answer 16

a) anaesthetic consent implied in surgical consent or e) nil consent required if would be in patients interest/ not against wishes https://journals.sagepub.com/doi/pdf/10.1177/0310057X1003800504 The anaesthetist should give the parent or relative the same kind of information as a patient and recommend the appropriate procedure. The consent of a parent or relative is lawful authority to proceed. If the parent or relative does not wish to take this role, it may be necessary for a court or a guardianship body to appoint someone else to make the decision. This may take some time, and if the procedure is medically necessary and cannot be deferred, then reasonable treatment may be administered without consent (this is a principle of the common law and, in some jurisdictions, is also in legislation: for example, in New South Wales, the Guardianship Act 1987 (NSW) s 37; and in Victoria

Answer 17

e. Oxygen consumption/min divided by HR VO2/HR: oxygen consumption divided by HR, known as the ‘oxygen pulse’ (ml beat–1) https://www.bjaed.org/article/S2058-5349(19)30021-6/fulltext The objective of CPET is to determine functional capacity in an individual. Deficiencies in CPET-derived variables—specifically: 1. ventilatory anaerobic threshold (AT) 2. peak O2 consumption (VO2peak) 3. ventilatory efficiency for carbon dioxide (VE/VCO2) —are associated with poor postoperative outcomes (mortality, morbidity, admission to intensive care, and length of hospital stay) after intra-abdominal surgery. 7. Does the oxygen pulse increase with exercise? The oxygen pulse is the VO2 divided by HR, and represents the product of the stroke volume and the arterial-venous oxygen difference. It can be seen in panel 2 and can be viewed as a surrogate for stroke volume, and as such should increase at the start of exercise before slowly reaching a plateau at its highest predicted value.

Answer 18

b) 1 or more RF

Answer 19

d. asepsis Asepsis: the prevention of microbial contamination of living tissues or sterile materials. Disinfection: the inactivation of non-sporing organisms using either thermal or chemical means. Sterilisation: complete destruction of all micro-organisms, including spores. https://www.anzca.edu.au/getattachment/e4e601e6-d344-42ce-9849-7ae9bfa19f15/PG28(A)-Guideline-on-infection-control-in-anaesthesia

Answer 20

History of eczema APRICOT study

Answer 21

4 | GCS 7-12

Answer 22

50 4th consensus guidelines for management of PONV

Answer 23

D 90 A-a = PAO2 - PaO2 Alveolar air equation gives PAO2 PAO2 = PiO2 - PaCO2 / R PAO2 = 0.4 x (760 - 47) - 48 / 0.8 so, as PaO2 given as 135 A-a = 228 - 135 = 93

Answer 24

1 hour ASRA: 1 hour Although the occurrence of a bloody or difficult neuraxial needle placement may increase risk, there are no data to support mandatory cancellation of a case. Direct communication with the surgeon and a specific risk-benefit decision about proceeding in each case are warranted. Currently, insufficient data and experience are available to determine if the risk of neuraxial haematoma is increased when combining neuraxial techniques with the full anticoagulation of cardiac surgery. We suggest postoperative monitoring of neurologic function and selection of neuraxial solutions that minimise sensory and motor block to facilitate detection of new/progressive neurodeficits. NYSORA: Administration of intravenous heparin intraoperatively should be delayed for at least 1 hour after epidural placement; a delay before administration of subcutaneous heparin is not required. In cases of full heparinization for CPB, additional precautions include delaying surgery for 24 hours in the event of a traumatic tap, tightly controlling the heparin effect and reversal, and removing catheters when normal coagulation is restored.

Answer 25

200mg Hydrocortisone or 25mg Prednisolone Conversion Prednisone 1mg = Hydrocortisone 4mg = Dexamethasone 0.15mg = Triamcinolone 0.8mg = Methylprednisolone 0.8mg = Betamethasone 0.15mg = (https://litfl.com/corticosteroids-overview/)

Answer 26

c) Embolic Blue Book 2017 Perioperative Stroke Epidemiology A perioperative stroke is defined as one that occurs either intra-operatively or in the post-operative period within 30 days70. Perioperative strokes are associated with an increased length of stay and a six-fold increased mortality. Any combination of surgery and anaesthesia is associated with an increased risk of stroke irrespective of the type of surgery. This may relate to coagulation changes The most common type of perioperative stroke is ischaemic stroke of embolic origin (heart or aorta). Hypotension is rarely the cause of perioperative stroke. Haemorrhagic stroke is uncommon which probably reflects the fact that severe hypertension during anaesthesia is a rare event, and anticoagulants have typically been withheld. The risk of perioperative stroke varies depending on the type of the surgery and patients’ risk factors. Procedural risk Urgent surgery is associated with an increased risk of stroke when compared to elective surger. Cardiac, vascular and brain surgeries are defined as “high-risk” as these have an increased risk of stroke when compared to other types of surgery. Valvular and aortic repair surgeries have a stroke risk as high as 8 to 10 per cent. Perioperative strokes in non-high-risk surgery are relatively rare and are estimated to have an incidence of about 1/1000 cases80. Patients’ risk factors >Age >history of previous stroke or transient ischaemic attack >renal failure >atrial fibrillation >history of cardiovascular diseases are identified risk factors for perioperative stroke. Atrial fibrillation is associated with a two-fold increase in the risk of death and stroke after carotid endarterectomy.

Answer 27

Lean Body Weight For infusion: Adjusted body weight NDMB: Lean Body weight Sux: Total body weight Source: SOBA UK

Answer 28

B do blood patch at lumbar level with no further investigation

Answer 29

d) Respiratory Acidosis with incomplete compensation Uncertain of this answer, not enough info to calculate anion gap pH 7.2 = acidaemia pCO2 84 = respiratory acidosis HCO3 43 = metabolic alkalosis as compensation BE 16 = metabolic alkalosis Boston rules: Chronic fully compensated Respiratory acidosis Expected compensation is 3-4 mmol/L rise for every 10mmHg rise in PCO2. Expected metabolic compensation therefore is HCO3 = 24 + 4 x ((84-40)/10) = 24 + 4x (44/10) = 24 + 4 x (4.4) = 24 + 17.6 = 41.6 Metabolic acidosis PaCO2 should be 1.5 x HCO3 + 8 = 72.5 Rules (from K.Brandis Acid-base rules anaesthesia mcq): - 1 for 10 (acute resp acidosis), 4 for 10 (chronic resp acidosis) - 2 for 10 (acute resp alkalosis), 5 for 10 (chronic resp alkalosis) - 1.5xHCO + 8 = expected pCO2 in a metabolic acidosis - 0.7xHCO3 + 22 = expected pCO2 in a metabolic alkalosis https://www.anaesthesiamcq.com/AcidBaseBook/ab9_3.php

Answer 30

SS /GCS Repeat APMSE

Answer 31

a. 35 Major updates (2022) to 1991 National Institutes of Health guidelines for bariatric surgery Metabolic and bariatric surgery (MBS) is recommended for individuals with a body mass index (BMI) 35 kg/m2 , regardless of presence, absence, or severity of co-morbidities. MBS should be considered for individuals with metabolic disease and BMI of 30-34.9 kg/m2 BMI thresholds should be adjusted in the Asian population such that a BMI 25 kg/m2 suggests clinical obesity, and individuals with BMI 27.5 kg/m2 should be offered MBS. Long-term results of MBS consistently demonstrate safety and efficacy. Appropriately selected children and adolescents should be considered for MBS. https://www.soard.org/article/S1550-7289(22)00641-4/fulltext#:~:text=The%201991%20NIH%20Consensus%20Statement,surgery%20that%20is%20applied%20universally Contraindications: - Inflammatory disease of GI tract (ulcers, oesophagitis, Crohn's) - Upper GI bleeding - Portal Htn - Liver Cirrhosis - Chronic Pancreatitis - Laparascopic surgery may be technically difficult in patients weighing >180kg and may be considered a relative contraindication

Answer 32

a) Stopping caffeine Eat a well-balanced diet that's low in salt Limit alcohol Enjoy regular physical activity Manage stress Maintain a healthy weight Quit smoking Foods that are rich in potassium are important in managing high blood pressure (HBP or hypertension) because potassium lessens the effects of sodium. The more potassium you eat, the more sodium you lose through urine. Potassium also helps to ease tension in your blood vessel walls, which helps further lower blood pressure. Source AHA

Answer 33

e. Hypotension https://www.safetyandquality.gov.au/sites/default/files/2022-06/sepsis_clinical_care_standard_2022.pdf

Answer 34

28 days Aprepitant PI: "Alternative or "back-up" measures of contraception should be used during treatment with this medicine and for one month following the last dose of this medicine." Pharmacokinetics: - aprepitant is a CYP3A4 inhibitor - caution is also advised with warfarin and phenytoin use

Answer 35

pain score

Answer 36

Mast cell degranulation - anaphylactoid reaction

Answer 37

a. Obesity Obesity and pulmonary function testing https://www.jacionline.org/article/S0091-6749(05)00164-8/fulltext - Full pulmonary function tests are often necessary to better characterize the spirometric abnormalities seen in the obese patient - The most sensitive indicator of obesity is a low expiratory reserve volume (ERV) and functional residual capacity - Restriction is seen in more severe obesity, with reductions in TLC and FVC. - However, residual volume is often preserved because of the relative high closing volume in relation to ERV.

Answer 38

a. 3 (snoring, BMI, Htn) Snoring loudly Tiredness during day time Observed Apnoea Pressure: Htn BMI > 35 Age > 50 Neck circumference >40cm (43cms male) Gender: Male

Answer 39

B. Cardiac hernation https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.109.896829

Answer 40

d) aortic dilation Osteoarthritis nerve compression syndrome due to bony overgrowth, and carpal tunnel syndrome Hypertension Diabetes mellitus Cardiomyopathy/HF Colorectal cancer Sleep Apnea Thyroid nodules and thyroid cancer Hypogonadism Compression of the optic chiasm Source: BJA

Answer 41

a. Barrier protection for a week In the case of non-oral hormonal contraceptives, the patient must use an additional non hormonal contraceptive method for the next 7 days

Answer 42

b. 24 hours ASA guidelines -If creatinine clearance >/=30 ml.min-1 (Cockcroft-Gault), proceed with surgery after two half lives (24 h) since the last dose, under general anaesthesia (or spinal anaesthesia if indicated) - If creatinine clearance < 30 ml.min-1, proceed with surgery after four half lives (48 h) since the last dose, under general anaesthesia (or spinal anaesthesia if indicated)

Answer 43

d) Reduced RR BJA: HFNP oxygen therapy https://www.bjanaesthesia.org/article/S0007-0912(17)53999-9/fulltext - reduced RR - increased MV - reduced WOB, reduced Vd, reduced AWR - provides CPAP 3-7 cmH20 (mouth closed)

Answer 44

HOCM if these remembered options are correct Alternative is Aortic Stenosis which is more common than HOCM in this age group

Answer 45

Absolute most = Insulin, but probably not an option. Sulphonylureas most likely

Answer 46

Answer: c) MS CEACCP 2012 Neuromuscular disorders and anaesthesia. Part 2: specific neuromuscular disorders Multiple sclerosis This is the most frequently occurring demyelinating neuromuscular disorder. It is a chronic relapsing condition characterized by the formation of plaques within the brain and spinal cord. These plaques cause demyelination around the axons, resulting in weakness and spasticity as well as sensory dysfunction. Anaesthetic considerations. Local anaesthetics may exacerbate symptoms due to the increased sensitivity of demyelinated axons to local anaesthetic toxicity. Non-depolarizing neuromuscular blocking agents may be used in normal doses. Caution should be exercised when using depolar- izing neuromuscular blocking agents if the patient is debilitated. Temperature maintenance is important as symptoms can deteriorate with an increase in temperature, as demyelinated axons are also more sensitive to heat. BJA: Perioperative management of myasthenia gravis (2021 - written after this MCQ): Several factors, many associated with surgery and anaesthesia, may exacerbate myasthenia or lead to a myasthenic crisis, a life-threatening condition in which severe respiratory muscle insufficiency leads to respiratory failure. Crises are most commonly precipitated by infection. Other precipitants include surgery, residual neuromuscular block, pain, many drugs, hypo- and hyperthermia, reduction or withdrawal of treatment, pregnancy, stress and sleep deprivation.

Answer 47

d. Urine osmolarity <100 DIAGNOSTIC CRITERIA >hypotonic hyponatraemia >urine osmolality > plasma osmolality (<275mOsm/kg) (i.e. concentrated urine despite hypotonic blood) >urinary Na+ > 20mmol/L >normal renal, hepatic, cardiac, pituitary, adrenal and thyroid function >euvolaemia (absence of hypotension, hypovolaemia, and oedema) correction by water restriction CAUSES (MAD CHOP) Major Surgery >abdominal >thoracic >transsphenoidal pituitary surgery (6-7 days post op) ADH production by tumours (Ectopic) >small cell bronchogenic carcinoma >adenocarcinoma of pancreas/duodenum >leukaemia >lymphoma >thymoma Drugs >antidepressants (e.g. SSRI, TCAs, MAOIs) >psychotropics (e.g. haloperidol, chlorpromazine), carbamazepine, Na+ valproate) >anaesthetic drugs (barbiturates, inhalational agents, oxytocin, opioids) >ADH analogues (vasopressin, DDAVP) >chemotherapy (e.g.Vinca alkaloids, Melphalan, Methotrexate and cyclophosphamide) >others (e.g. NSAIDs, amiodarone, ciprofloxacin, morphine, MDMA, proton pump inhibitors) CNS Disorders >cerebral trauma >brain tumour (primary or metastases) >meningitis/encephalitis >brain abscess >SAH >acute intermittent porphyria >SLE Hormone deficiency >hypothyroidism >adrenal insufficiency Others >Guillain-Barre Syndrome >HIV infection (early symptomatic or AIDS) >hereditary SIADH >giant cell arteritis >idiopathic (occult small cell or olfactory neuroblastoma) Pulmonary Disorders >pneumonia (viral, fungal, bacterial) >TB >lung abscess MANAGEMENT 1. see hyponatraemia 2. fluid restrict 3. incremental increase in Na+ if indicated to avoid central pontine myelinolysis 4. medications to decrease ADH secretion >Demeclocycline >Tolvaptan / Conivaptan

Answer 48

e Na 140 Mg 1.5 K 5.0 acetate 27 lactate 0

Answer 49

d) 10 minutes - best answer; one of those shit questions that depends on your source. Morgan & Mikhail's (chapter 36: anaesthesia for ophthalmic surgery): " Succinylcholine increases IOP by 5-10mmHg for 5-10 minutes". - due to prolonged contracture of the EOM BARASH: Succinylcholine increases IOP 7 to 10 mmHg reaching a peak pressure 1 to 2 minutes after IV administration and returns to the baseline in 5 to 7 minutes. This increase may be attenuated by pretreatment with anesthetics, although none completely eliminates the increase in IOP. In the presence of a lacerated globe, this increase in IOP may increase the extrusion of intraocular contents although greater increases in IOP may occur during crying and coughing. Yao & Artusio's: - also quotes same information: increases IOP 7 to 10mmHg, returning to baseline in 5 - 7 minutes. Stoelting's: Intraoccular pressure peaks at 2-4 minutes after administration and returns to normal by 6 minutes

Answer 50

a. Splenomegaly Associated with high doses >4mg/kg/hr and prolonged use (>48hrs) Safe doses of propofol infusion for sedation in ICU are considered to be 1-4mg/kg/hr -> fatal Cases pf PRIS have been reported after infusion doses as low as 1.9-2.6mg/kg/hr Risk factors: i. Young age ii. Critical illness iii. High fat and low Carbohydrate intake iv. Inborn errors of mitochondrial fatty acid oxidation v. Catecholamine infusion/ High catecholamine and glucocorticoid levels vi. Steroid therapy vii. Severe head injuries Characteristics: i. Bradycardia ii. Severe metabolic acidosis iii. Cardiovascular collapse iv. Rhabdomyolysis v. Hyperlipidaemia vi. Renal failure vii. Hepatomegaly Management: - Routine monitoring of CK and triglycerides should be performed for the at risk population ○ Daily CK and triglyceridees after 48hrs of propofol infusion ○ Increasing CK in the absence of other pathology triggers suspiscion of PRIS - Propofol immediately stopped and alternative (midazolam and alfentanil) are used - PRIS is difficult to treat once it occurs - CVS support provided as needed - Renal replacement therapy may be required to treat lactic acidosis, clear propofol and its metabolites from the patient rapidly - Catecholamine resistant shock has been reported - Pacing has been used with limited success ECMO has been reported and successfully used in the CVS support of PRIS

Answer 51

A. Reduced RR BJA HFNOT It has been demonstrated that patients with acute hypoxaemic respiratory failure experience improved comfort and tolerance with HFNOT compared with humidified oxygen via a facemask, and traditional non-invasive ventilation masks. Subjective feelings of dyspnoea AND RESPRIATORY RATES are REDUCED as is airway dryness.

Answer 52

e) VVI with intermittent failure to sense

Answer 53

e. Increased risk of non fatal cardiac arrest POISE II * clonidine 200mcg per day - did not reduce the rate of composite outcome of death or nonfatal MI - but it increased the risk of clinically important hypotension and nonfatal cardiac arrest * aspirin initiation or continuation – no significant effect on rate of composite of death or non fatal MI but increased risk of major bleeding

Answer 54

a. increased bleeding and normal aptt and inr Bleeding because cold = we know this Haemtology analyzer in labs warms blood to 37.2 degrees (fixes hypothermia on sample)

Answer 55

f. perindopril Hypotensive transfusion reactions, which account for almost 3% of all transfusion reactions, are associated with patients treated with angiotensin-converting enzyme inhibitors. The current hypothesis suggests that they are caused by bradykinin-induced vasodilation in the absence of allergic, hemolytic, or septic mechanisms. The hypotension observed frequently is unresponsive to conventional therapy with catecholamines. The suggested intraoperative management includes cessation of transfusion and washing red blood cells before blood replacement. Hypotensive reactions to transfusion may not always be recognized. To prevent these reactions, clinicians have several options: they may discontinue the ACE inhibitor (elective transfusion), not use a leukoreduction filter (if the patient has no absolute requirement for leukoreduced blood components), use washed cellular components, or use components that have undergone leukoreduction at the collection facility or the hospital blood bank before transfusion (since bradykinin is degraded during storage).

Answer 56

Decreased SVR - increased CO, increased SBP and decreased DBP with widened PP Up to Date Cardiovascular - Patients with hyperthyroidism have an increase in cardiac output, due both to increased peripheral oxygen needs and increased cardiac contractility. Heart rate is increased, pulse pressure is widened, and peripheral vascular resistance is decreased

Answer 57

RCA or LCx https://litfl.com/mi-localization-ecg-library/

Answer 58

a. 1% i.e. what is the positive predictive value (PPV) for this test PPV= TP/ TP +FP Negative Predictive Value = TN / TN + FN Prevalence of 1/1000 Sensitivity of 100% Specificity of 90% Of patients that are disease positive in population of 1000 TP = 1 FN = 0 -> 100% sensitivity Of patients that are disease negative in population of 1000 FP = 99 TN = 900 -> 90% Specificity PPV= 1/ 1 + 99 = 1/100 =1% NPV= 900/ 900 + 0 = 1/1 = 100%

Answer 59

a) delayed gastric emptying

Answer 60

B. 7.32 https://emj.bmj.com/content/18/5/340 The values of pH on arterial and venous samples were highly correlated (r=0.92) with an average difference between the samples of −0.4 units. There was also a high level of agreement between the methods with the 95% limits of agreement being −0.11 to +0.04 units. https://litfl.com/vbg-versus-abg/ pH - Good correlation - pooled mean difference: +0.035 pH units

Answer 61

A Apnea is defined as the cessation of airflow for ten or more seconds. Hypopnea is defined as a recognizable, transient reduction, but not a complete cessation of, breathing for ten or more seconds. Hypopnea requires a 4% fall in SpO2 https://www.ncbi.nlm.nih.gov/books/NBK441909/#:~:text=Obstructive%20Sleep%20Apnea%20(OSA)%2C,for%20ten%20or%20more%20seconds.

Answer 62

b IV fluids and KCL UTD Stricture post Lap Sleeve Gastrectomy management Although sleeve strictures have been reported in 0.26 to 4 percent of LSG operations, <1 percent result in symptoms that require endoscopic or surgical intervention A stricture can manifest acutely, early after surgery, or more chronically. Although strictures can occur anywhere along the long staple line, they are most often located at the level of the incisura angularis for anatomic reasons. The etiologies of post-LSG strictures are either mechanical or functional. Mechanical strictures usually derive from the use of small bougies, stapling too close to the bougie (especially at the incisura angularis), twisting of the staple line creating a "spiral" sleeve, or aggressive imbrication of the staple line. Functional stenoses derive from edema or hematomas at the staple line. As a result, functional stenoses are transient, which present immediately following LSG and resolve spontaneously with expectant treatment. Patients who present with obstructive symptoms during the early postoperative period should be resuscitated with hydration and antiemetic medications and studied with an upper gastrointestinal (UGI) series. Stable patients with a stricture can be observed to allow postsurgical mucosal edema to resolve, typically in 24 to 48 hours. Patients who cannot handle their own secretions require nasogastric tube decompression, preferably placed under fluoroscopic guidance. Patients with an acute stricture who do not respond to conservative management require early surgical reintervention. Laparoscopy could demonstrate kinking of the gastric tube, a tight suture, or a compressing hematoma. ●Endoscopy is a good initial treatment for short-segment strictures, most of which can be dilated with balloons. Multiple treatments in four- to six-week intervals are sometimes needed to treat the stricture and improve patient symptoms. Stents have also been tried but are not effective for post-LSG strictures. ●Laparoscopic seromyotomy is a treatment option for long-segment strictures . In a small retrospective study, patients treated with laparoscopic seromyotomy had good symptomatic relief. ●Conversion to an RYGB is the last option for patients with a refractory stricture who have failed all other treatments.

Answer 63

c) 0, 1, 4, 24 Serum tryptase levels are recommended to be collected as soon as possible after the onset of symptoms and then at 1 hour, 4 hours and after 24 hours. https://www.anzca.edu.au/resources/professional-documents/endorsed-guidelines/anaphylaxis-guideline-2022.pdf

Answer 64

e) Interquartile Range https://statisticsbyjim.com/basics/skewed-distribution/ https://statisticsbyjim.com/basics/variability-range-interquartile-variance-standard-deviation/ A measure of variability is a summary statistic that represents the amount of dispersion in a dataset. How spread out are the values? While a measure of central tendency describes the typical value, measures of variability define how far away the data points tend to fall from the center. In statistics, variability, dispersion, and spread are synonyms that denote the width of the distribution. Just as there are multiple measures of central tendency, there are several measures of variability. When a distribution has lower variability, the values in a dataset are more consistent. However, when the variability is higher, the data points are more dissimilar and extreme values become more likely. Consequently, understanding variability helps you grasp the likelihood of unusual events. > Range is easy to understand, it is based on only the two most extreme values in the dataset, which makes it very susceptible to outliers. If one of those numbers is unusually high or low, it affects the entire range even if it is atypical. >The interquartile range is the middle half of the data. To visualize it, think about the median value that splits the dataset in half. The interquartile range is the middle half of the data that is in between the upper and lower quartiles. In other words, the interquartile range includes the 50% of data points that fall between Q1 and Q3 > The interquartile range is a robust measure of variability in a similar manner that the median is a robust measure of central tendency. Neither measure is influenced dramatically by outliers because they don’t depend on every value. Additionally, the interquartile range is excellent for skewed distributions, just like the median. > when you have a normal distribution, the standard deviation tells you the percentage of observations that fall specific distances from the mean. However, this doesn’t work for skewed distributions, and the IQR is a great alternative. > Variance is the average squared difference of the values from the mean. Unlike the previous measures of variability, the variance includes all values in the calculation by comparing each value to the mean. To calculate this statistic, you calculate a set of squared differences between the data points and the mean, sum them, and then divide by the number of observations. Hence, it’s the average squared difference. >While higher values of the variance indicate greater variability, there is no intuitive interpretation for specific values. Despite this limitation, various statistical tests use the variance in their calculations. For an example, read my post about the F-test and ANOVA. While it is difficult to interpret the variance itself, the standard deviation resolves this problem! > The standard deviation is the standard or typical difference between each data point and the mean. When the values in a dataset are grouped closer together, you have a smaller standard deviation. On the other hand, when the values are spread out more, the standard deviation is larger because the standard distance is greater > The standard deviation is just the square root of the variance. Recall that the variance is in squared units. Hence, the square root returns the value to the natural units. The symbol for the standard deviation as a population parameter is σ while s represents it as a sample estimate. To calculate the standard deviation, calculate the variance as shown above, and then take the square root of it. Voila! You have the standard deviation! > People often confuse the standard deviation with the standard error of the mean. Both measures assess variability, but they have extremely different purposes. > When you have normally distributed data, or approximately so, the standard deviation becomes particularly valuable. You can use it to determine the proportion of the values that fall within a specified number of standard deviations from the mean. For example, in a normal distribution, 68% of the values will fall within +/- 1 standard deviation from the mean. This property is part of the Empirical Rule. This rule describes the percentage of the data that fall within specific numbers of standard deviations from the mean for bell-shaped curves.

Answer 65

b) Subclinical Hyperthyoirdism Subclinical hyperthyroidism: low TSH, normal T3 + T4 Clinical hyperthyroidism: low TSH, high T3, high/normal T4 Subclinical hypothyroidism: high TSH, normal T3 + T4 Clinical hypothyroidism: high TSH, low/normal T3, i T4 Amiodarone: high/normal TSH, low T3 (2o to inhibition of pituitary T4 to T3 conversion) Sick euthyroid: low TSH, low T3 Hypophysectomy (central hypothyroidism): low/normal TSH/T3/T4 Compliant on thyroxine: normal TSH, high/normal T3, low T4 Non-compliant w thyroxine (pt taking several tabs prior to Dr’s appointment): high TSH, normal T4

Answer 66

c. Lupus anticoagulant (normal PT, raised APTT) Lupus anticoagulant (more likely to be associated with thrombosis than bleeding) ## Footnote https://www.uptodate.com/contents/image?imageKey=HEME%2F79969

Answer 67

c) Discharge from recovery Aldrete score, which includes five elements (activity, respiration, circulation, consciousness, oxygen saturation) [16]. The original scoring system was developed before the invention of pulse oximetry and used the patient's colouration as a surrogate marker of their oxygenation status. A modified Aldrete scoring system was described in 1995 which replaces the assessment of skin colouration with the use of pulse oximetry to measure SpO2. The Modified Aldrete system includes five additional elements that are particularly useful during the Phase II recovery period prior to discharge to home (dressing, pain, ambulation, feeding, urine output)

Answer 68

a) Ischaemic optic neuropathy Postoperative visual loss (POVL) occurs in 1/60 000–1/125 000 operations. Spinal surgery has the highest incidence of POVL. American Society of Anesthesiologists (ASA) Post Operative Visual Loss Registry, spinal surgery accounted for 93/131 (70%) of all cases of visual loss after non-ophthalmic surgery. Of these: > 83 were attributable to ischaemic optic atrophy (ION) > 10 were caused by central retinal artery occlusion (CRAO). CRAO - caused by direct pressure on the globe causing raised intraocular pressure and compromising retinal perfusion. - visual loss is usually unilateral and associated with other signs of pressure (e.g. ophthalmoplegia, ptosis, or altered sensation in the territory of the supraorbital nerve). - Initial careful positioning of the head and regular checks throughout the procedure in case of movement minimizes the risk - documentation of eye checks should occur every 30mins and horseshoe shaped head rests should be avoided in prone patients ION > associated with: - male gender - obesity - increasing blood loss - operative procedures >6 hrs in length. - The use of the Wilson frame has also been implicated. > final common pathway is thought to be hypoperfusion of the optic nerve, there is no clear association with either intraoperative systemic hypotension or with the presence of peripheral vascular disease or diabetes. > recently updated ASA practice advisory for POVL associated with spinal surgery recommends regular intraoperative testing of haemoglobin concentration. However, it was unable to suggest a transfusion threshold that would prevent POVL. Other possible causes of POVL: 1. Cortical ischaemia 2. Haemorrhage into a cerebral tumour. In high-risk cases, assessment of vision should be performed as soon as possible in PACU and an early ophthalmic opinion sought if there is a suggestion of visual compromise. Initial management 1. optimization of arterial pressure 2. oxygenation 3. correction of anaemia. Treatment with agents such as acetazolamide has not been beneficial and there is rarely any useful improvement in vision with either injury, so attention should be focused on preventative measures: 1. Careful positioning with the head at the same level as the heart 2. Meticulous haemostasis, 3. Possibly staging prolonged procedures should be considered. Because of the devastating nature of this complication, patients should be informed of an increased incidence of visual loss after spinal operations that are expected to be of prolonged duration and associated with significant blood loss.

Answer 69

dopamine - least likely to cause pulmonary vasodilation (all the others do to my knowledge) - From UP TO DATE: > At low doses of 1 to 3 mcg/kg per min, dopamine acts primarily on dopamine-1 receptors to dilate the renal and mesenteric artery beds > At 3 to 10 mcg/kg per min (and perhaps also at lower doses), dopamine also stimulates beta-1 adrenergic receptors and increases cardiac output, predominantly by increasing stroke volume with variable effects on heart rate. > At medium-to-high doses, dopamine also stimulates alpha-adrenergic receptors, although a small study suggested that renal arterial vasodilation and improvement in cardiac output may persist as the dopamine dose is titrated up to 10 mcg/kg per min *clinically, the haemodynamic effects of dopamine demonstrate individual variability Dobutamine (inodilator): - selective β1-agonist that increases cardiac contractility and reduces pulmonary vascular and systemic vascular resistances Vasopressin: - vasopressin may have pulmonary vasodilatory effects in addition to a systemic vasoconstrictive effect Milrinone (inodilator): - the phosphodiesterase-3 inhibitors, milrinone and enxoimone, have positive inotropic effects combined with the capacity to reduce RV afterload (‘inodilators’) without significant chronotropic effect, but they can be associated with significant systemic hypotension

Answer 70

b. Insufficient fludrocortisone replacement In Primary Adrenal Insufficency, cortisol deficiency results in decreased feedback to the HPA axis, leading to increased secretion of ACTH to stimulate the adrenal cortex. Simultaneously, MCs deficiency causes increased release of renin by the juxtaglomerular apparatus of the kidneys.

Answer 71

8mg/hr Guidelines for mx of glucocorticoids during the perioperative period for patients with adrenal insufficiency https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.14963

Answer 72

c) 15mg Oral Tapentadol 25mg = 8mg Oral Morphine Oral Oxycodone 5mg = 8mg Oral Morphine Oral Tramadol 25mg = Oral Morphine 5mg Oral Hydromorphone 4mg = Oral Morphine 20mg S/L Buprenorphine 200mcg = 8mg Oral Morphine IV Oxycodone 5mg = Oral Morphine 15mg IV Morphine 5mg = Oral Morphine 15mg IV Hydromorphone 1mg = Oral Morphine 15mg

Answer 73

gelofusin Anaphylaxis after vaccination is probably due to anaphylactic sensitivity to gelatin or neomycin, not an egg allergy

Answer 74

d) Reduce length of stay less time in aged care and reduced mortality Blue book 2019: "A referral to a geriatrician for further assessment and management may also be warranted in the preoperative period. Indeed, a meta-analysis of perioperative interventions to reduce delirium found that a geriatrics consultation before surgery was one of only two perioperative interventions that were associated with a reduction in delirium." Association of anaesthetists: The impact of pre-operative comprehensive geriatric assessment on postoperative outcomes in older patients undergoing scheduled surgery: a systematic review - reduced medical complications > reduced postop delirium, > reduced pneumonia > reduced pressure sores - fewer cancellations - reduced length of stay

Answer 75

e. 200mmol K+ < 3.0 mmol/L: 200-400 mmol of potassium are required to raise it by 1 mmol/L K+ > 3.0 mmol/L: 100-200 mmol of potassium are required to raise it by 1 mmol/L Hypokalaemia P. GLOVER https://www.cicm.org.au/CICM_Media/CICMSite/CICM-Website/Resources/Publications/CCR Journal/Previous Editions/September 1999/05-Sept_1999_Hypokalaemia.pdf If the serum potassium level is greater than 3 mmol/L, 100-200 mmol of potassium are required to raise it by 1 mmol/L; 200 - 400 mmol are required to raise the serum potassium level by 1 mmol/L when the potassium concentration is less than 3mmol/L, assuming a normal distribution between cells and the intracellular space, and a linear relationship between plasma potassium and body deficit (which has been described, i.e. 0.27 mmol/L/100 mmol deficit/70 kg), exists. The rate of administration of potassium will be influenced by the presence and seriousness of the pathophysiological changes caused by hypokalaemia. The underlying disorder should also be treated simultaneously.

Answer 76

b. 45ml/hr N saline w 5% dextrose Nsaline + 5% dextrose is fluid of choice A guide to paediatric anaesthesia fluid management -421 rule overestimates fluid resus -due to stress response from ADH release -post-op fluid maintenance is 2/3rds calculated due to increased ADH -never use hypotonic fluids https://www.rch.org.au/clinicalguide/guideline_index/Intravenous_fluids/

Answer 77

a) 50mg six times a day 42mg IV Morphine = 126mg Oral Morphine 126/8= 15.75 15.75 x 25 = 393.75 (*400mg/day Tapentadol) Option 50mg 6 times a day = 300mg As direct OME to tapentadol conversion is 400mg, a 300mg dose represents a 25% dose reduction, which is line with a 25-50% dose reduction due to incomplete cross-tolerance during opioid rotation. Oral Tapentadol 25mg = 8mg Oral Morphine Oral Oxycodone 5mg = 8mg Oral Morphine Oral Tramadol 25mg = Oral Morphine 5mg Oral Hydromorphone 4mg = Oral Morphine 20mg S/L Buprenorphine 200mcg = 8mg Oral Morphine IV Oxycodone 5mg = Oral Morphine 15mg IV Morphine 5mg = Oral Morphine 15mg IV Hydromorphone 1mg = Oral Morphine 15mg

Answer 78

a. Cholecystitis Example and explanation taken from RACGP: The raised AlP relative to Alt suggests cholestasis and the high GGt confirms liver origin. The mild hyperbilirubinaemia confirms the clinical impression of jaundice. Biliary disease is highly likely with gallstones the most likely differential diagnosis. however, this clinical picture may also occur in drug reactions or infiltrative conditions. After a careful history, abdominal ultrasound is the most appropriate next investigation.

Answer 79

b. Unstable angina Not a Repeat, no Tropnin rise in this question making the answer unstable angina as opposed to NSTEMI UTD: Unstable angina (UA) and acute non-ST elevation myocardial infarction (NSTEMI) differ primarily in whether the ischemia is severe enough to cause sufficient myocardial damage to release detectable quantities of a marker of myocardial injury (troponins): ●UA is considered to be present in patients with ischemic symptoms suggestive of an ACS and no elevation in troponins, with or without electrocardiogram changes indicative of ischemia (eg, ST segment depression or transient elevation or new T wave inversion). ●NSTEMI is considered to be present in patients having the same manifestations as those in UA, but in whom an elevation in troponins is present. MINS: Myocardial injury after non-cardiac surgery (up to 30 days post-op): 1. Elevated postop troponin 2. Resulting from myocardial ischaemia (i.e. no evidence of a non-ischaemic aetiology), not requiring an ischaemic feature (i.e. no chest pain, no ECG change) VISION studies (Vascular Events in Noncardiac Surgery Patients Cohort Evaluation) demonstrated that severity of MINS strongly associated with 30-day mortality after NCS. hs-cTnT <20ng/L ~ 0.5% 30 day mortality 20-64ng/L ~3% 30 day mortality 65-999 ng/L ~9% 30 day mortality >1000ng/L ~30% 30 day mortality Whilst VISION trial identified MINS in at risk patients, the question now becomes what interventions are available to prevent this complication?

Answer 80

e. 45ml/hr 0.9% NS 5% dextrose REPEAT 2/3rd standard full maintenance as unwell

Answer 81

c. Pharyngeal muscles Millers Anaesthesia: Reference artyicle from Millers: https://pubs.asahq.org/anesthesiology/article/92/4/977/710/The-Incidence-and-Mechanisms-of-Pharyngeal-and An adductor pollicis TOF ratio of 0.90 or less was associated with impaired pharyngeal function and airway protection, resulting in a four- to fivefold increase in the incidence of pharyngeal dysfunction causing misdirected swallowing. Moreover, pharyngeal function and airway protection may be impaired, even if the adductor pollicis muscle has recovered to a TOF ratio of more than 0.90.

Answer 82

Hypercalcaemia

Answer 83

Gilberts Gilbert’s syndrome is a benign genetic condition that commonly presents as incidental hyperbilirubinaemia or painless jaundice. It is relatively common with a population frequency of approximately 2–10%. Gilbert’s syndrome is caused by defective bilirubin clearance by the hepatic conjugating enzyme UDP-glucuronosyltransferase https://www.rcpa.edu.au/getattachment/8b9a8acf-f7f5-4088-951c-3f65f0c2f8fe/Interpreting-liver-function-tests.aspx

Answer 84

Unknown options but… Factors associated WITH difficulty during Gastroscopy were younger age, procedure indication, male sex, presence of a trainee, psychiatric history and benzodiazepine and opioid use. Factors associated with difficulty during COLONOSCOPY were younger age, female sex, BMI <25, procedure indication, tobacco, benzodiazepine, opioid and other psychoactive medication use

Answer 85

c) 20mmHg Intra-abdominal hypertension is defined as a sustained intra-abdominal pressure of >12 mm Hg, and abdominal compartment syndrome occurs at a pressure >20 mm Hg in association with new organ dysfunction. Intra-abdominal hypertension is graded as follows: Grade 1=12–15 mm Hg; Grade 2=16–20 mm Hg; Grade 3=21–25 mm Hg; and Grade 4 >25 mm Hg. ## Footnote https://academic.oup.com/bjaed/article/12/3/110/258792

Answer 86

a) polydipsia Hypocalcemia varies from a mild asymptomatic biochemical abnormality to a life-threatening disorder. Acute hypocalcemia can lead to paresthesia, tetany, and seizures (characteristic physical signs may be observed, including Chvostek sign, which is poorly sensitive and specific of hypocalcemia, and Trousseau sign). https://bestpractice.bmj.com/topics/en-us/160

Answer 87

a. Normal SpO2, Normal PaO2 ABG HbCO (elevated levels are significant, but low levels do not rule out exposure) lactate (tissue hypoxia) PaO2 should be normal, SpO2 only accurate if measured (not calculated from PaO2) MetHb (exclude) https://litfl.com/carbon-monoxide-poisoning/

Answer 88

E. Pulmonary Stenosis DERANGED PHYSIOLOGY: Splitting of the first heart sound Right bundle branch block can produce a split first heart sound - because the contraction of the right ventricle is delayed- the conduction occurs via the left ventricle rather than the bundle of His- and thefore the closure of the tricuspid valve occurs after a substantial delay. Atrial septal defect can result in a fixed split of the first heart sound Splitting of the second heart sound It is normal for this sound to be split. The high pressure in the systemic circulation slams the aortic valve shut rather abruptly, almost angrily. In contrast, low pressure of the pulmonary circulation tends to close the pulmonary valve gently, and therefore the pulmonary component of the second heart sound (P2) is usually delayed by about 20-30 milliseconds. It is also normal for increased right ventricular filling to cause a widening of the split. The more blood in the RV, the longer it takes to eject, and therefore the greater the delay until pulmonary valve closure. n the spontaneously breathing patient, the delay is greatest during inspiration. Naturally, in the patient ventilated with positive pressure the delay is greatest during expiration (positive pressure being a barrier to diastolic filling). Increased normal splitting of S2 Anything that delays the end of right ventricular systole can cause this sort of picture. Right bundle branch block - the delay in conduction via the left ventricle causes a delay in right ventricular contraction, and therefore a delay in pulmonary valve closure. The S1 will also be split. Ventricular septal defect - because the right ventricle receives a large volume load directly from the left ventricle, and therefore takes longer to complete its systolic contraction. Pulmonary valve stenosis - because the right ventricle takes longer to empty though a narrowed valve Mitral regurgitation- not because right ventricular contraction is delayed, but because left ventricular contraction is shortened (as the LV empties in both the aortic and the atrial directuion, systole is over very quickly). Fixed splitting of S2 Atrial septal defect - the atria, joined by a gaping hole in their seput, act as one atrium. The result is a reasonably equal distribution in volume betweent the right and left atrium. This way, both sides of the circulation share the same diastolic filling pressure. Dragging more volume into the right atrium with respiratory activity will not cause an inequality of ventricular filling (between the right and left ventricles) because the venous return will be "shared". Reversed splitting of S2 In this situation, P2 occurs before A2, and splitting widens during expiration (or inspiration in the mechanically ventilated patient). This only happens if the conduction to the left ventricle is delayed, or if the left ventricle is massively volume overload (and the right ventricle is not). Left bundle branch block - the left ventricle depolarises after the right ventricle, and A2 is delayed Aortic stenosis - the left ventricle empties slowly though a narrow valve Large patent ductus arteriosus - the left ventricle receives a backflow of blood from the aorta, which causes it to become volume-overloaded

Answer 89

a. Drugs that absolutely must not be used for pregnancy. (absolute contraindication) https://www.tga.gov.au/australian-categorisation-system-prescribing-medicines-pregnancy

Answer 90

a. 1-3 days

Answer 91

B II ASA II Paediatric examples: Asymptomatic congenital cardiac disease, well controlled dysrhythmias, asthma without exacerbation, well controlled epilepsy, non-insulin dependent diabetes mellitus, abnormal BMI percentile for age, mild/moderate OSA, oncologic state in remission, autism with mild limitations

Answer 92

d. pregnancy

Answer 93

E - SSRIs ANZCA PG12 Background Paper

Answer 94

c) Cease clopidogrel for 5 days, continue aspirin - prostatic surgery, the risk of major bleeding may be greater than the risk of stent thrombosis - For clopidogrel, we stop five days before surgery - Clopidogrel, if stopped, should be restarted with a loading dose of 300 mg as soon as possible after surgery, perhaps later in the day if postoperative bleeding has stopped. Some experts recommend a higher loading dose of 600 mg to decrease time to effectiveness in the higher-risk postoperative setting - suggest that surgery be performed in centers with 24-hour interventional cardiology coverage UP TO DATE: Noncardiac surgery after PCI Nonemergency noncardiac surgery — For patients who have undergone previous stenting with either BMS or DES and who will need cessation of one or both antiplatelet agents, we prefer to defer planned nonemergency, nonurgent noncardiac surgery until at least six months after stent implantation. The risks of noncardiac surgery before six months are increased after both BMS and DES. For patients whose surgery requires cessation of one or both antiplatelet agents and cannot wait six months, and where the risks of delaying surgery outweigh the benefits, our recommended minimal duration of DAPT is four to six weeks, depending on the urgency of surgery and risk of thrombotic complication. This is based in part on evidence suggesting that the increased risk of MI and cardiac death is highest within the first month after stent placement and no clear difference in risk between BMS and DES. Although we prefer to wait at least six weeks when possible, in patients for whom earlier surgery is in their best interest after weighing risks and benefits, we sometimes refer patients as early as four weeks after stent placement. The proinflammatory and prothrombotic risks of surgery may increase the baseline risk of stent thrombosis even in the presence of DAPT and regardless of stent type during this early period after stenting. We believe this risk to be higher prior to the minimum duration of DAPT recommended above, but the final decision to continue or discontinue antiplatelet therapy in the perioperative period should be made only after an informed discussion among the surgeon, managing cardiologist (and other health care providers), and patient has taken place. In many cases, DAPT can be continued in the perioperative period, although for some surgeries, such as neurosurgery, posterior eye surgery, or prostatic surgery, the risk of major bleeding may be greater than the risk of stent thrombosis. In these patients who undergo noncardiac surgery before the recommended minimum duration of DAPT, a platelet P2Y12 receptor blocker should be discontinued for as brief a period as possible. Aspirin should be continued through the perioperative period, since the risk of stent thrombosis is further increased with the cessation of both aspirin and clopidogrel and surgery can usually be safely performed on aspirin. The rationale to continue aspirin comes in part from the POISE-2 trial (PCI subgroup analysis), which is discussed separately. However, as many neurosurgical patients, for whom bleeding might be life threatening or lead to severe adverse outcomes, were not enrolled in POISE-2, the optimal strategy is not known. ●Minor surgical and dental procedures usually do not require cessation of antiplatelet therapy. ●With regard to stopping P2Y12 inhibitor prior to noncardiac surgery, we generally follow recommendations found in the manufacturer's package insert for each drug. - For clopidogrel, we stop five days before surgery; that is, the last dose is taken on the sixth day before surgery. - For prasugrel, we stop seven days before surgery. - For ticagrelor, we stop three to five days before surgery. - Some experts are willing to recommend shorter discontinuation periods for procedures less likely to be associated with major bleeding. ●Clopidogrel, if stopped, should be restarted with a loading dose of 300 mg as soon as possible after surgery, perhaps later in the day if postoperative bleeding has stopped. Some experts recommend a higher loading dose of 600 mg to decrease time to effectiveness in the higher-risk postoperative setting. ●We suggest that surgery be performed in centers with 24-hour interventional cardiology coverage

Answer 95

C) Cease clopidogrel for 5 days, continue aspirin WFSA update document https://resources.wfsahq.org/wp-content/uploads/uia29-Perioperative-management-of-patients-with-coronary-stents-for-non-cardiac-surgery.pdf Dual antiplatelet therapy should be continued in all patients with coronary stents presenting for surgery. However, if there is a high risk of surgical bleeding then clopidogrel should be stopped 5-7 days before surgery and monotherapy with aspirin should be continued. Clopidogrel should be restarted as soon as possible post surgery. Cessation of aspirin therapy may be considered during intracranial surgery and transuretheral resection of prostrate as these procedures are associated with an increased risk of bleeding, but only after contemplating the risk-benefit ratio. 2014 AHA/ACC guidelines on perioperative medicine don't give a firm answer except: > 180 days since insertion = proceed (Level II b evidence)

Answer 96

c. myasthenia gravis

Answer 97

d) Von willebrand disease - autosomal dominant inheritance - may have normal or prolonged APTT, PT is normal *Haem A: X-linked recessive disorder; would expect prolonged aPTT, and normal PT *Haem B: X-linked recessive disorder; would expect normal aPTT and normal PT Up to date: Inheritance patterns — Most cases of VWD are transmitted as an autosomal dominant trait; this includes types 1 and 2B, and most types 2A and 2M. Baseline hemostasis assessment — Most patients will have a complete blood count (CBC) with platelet count and coagulation studies during the initial evaluation for excessive bleeding or bruising. ●Individuals with VWD generally have a normal CBC and a normal platelet count, with the exception of those with type 2B VWD, most of whom will have mild thrombocytopenia (eg, platelet count 100,000 to 140,000/microL). ●Individuals with VWD may have a normal or prolonged activated partial thromboplastin time (aPTT), depending on the degree of reduction of the factor VIII level. The prothrombin time (PT) is normal in VWD. Up to date: ●Hemophilia A – Inherited deficiency of factor VIII (factor 8 [F8]); an X-linked recessive disorder. ●Hemophilia B – Inherited deficiency of factor IX (factor 9 [F9]); also called Christmas disease; an X-linked recessive disorder. Laboratory findings — Hemophilia is characterized by a prolonged activated partial thromboplastin time (aPTT). However, the aPTT may be normal in individuals with milder factor deficiencies (eg, factor activity level >15 percent), especially in hemophilia B (factor IX deficiency), where even individuals with moderate disease may have a normal aPTT. In some individuals with hemophilia A, factor VIII levels may increase with stress, leading to a normalization of the aPTT or mis-categorization of factor levels and disease severity. In patients with hemophilia, the aPTT corrects in mixing studies, unless an inhibitor is present, which only applies to individuals who have received factor infusions or who have an autoantibody such as a lupus anticoagulant or an acquired factor inhibitor. Mixing studies that do not show correction of a prolonged aPTT suggest an alternative diagnosis such as an acquired factor inhibitor. The platelet count and prothrombin time (PT) are normal in hemophilia. Thrombocytopenia and/or prolonged PT suggest another diagnosis instead of (or in addition to) hemophilia. Measurement of the factor activity level (factor VIII in hemophilia A; factor IX in hemophilia B) shows a reduced level compared with controls (generally <40 percent). One exception is an individual with mild hemophilia A who undergoes testing when stressed or pregnant and has a falsely elevated factor level. If this is suspected, factor activity testing should be repeated under conditions of low stress. The plasma von Willebrand factor antigen (VWF:Ag) is normal in hemophilia. If VWF:Ag is reduced, this suggests the possibility of von Willebrand disease (VWD) rather than (or in addition to) hemophilia. Urinalysis is not done routinely, but if performed it may sometimes (but not always) show microscopic or macroscopic hematuria.

Answer 98

D) Cefaclor 1. Cephalexin? More so than Cephazolin (no B-lactam) 2. Cefaclor Source: UpToDate

Answer 99

history of eczema

Answer 100

a) Urine osmolality <100mOsm/kg DIAGNOSTIC CRITERIA hypotonic hyponatraemia urine osmolality > plasma osmolality (<275mOsm/kg) (i.e. concentrated urine despite hypotonic blood) urinary Na+ > 20mmol/L normal renal, hepatic, cardiac, pituitary, adrenal and thyroid function euvolaemia (absence of hypotension, hypovolaemia, and oedema) correction by water restriction Source LITFL

Answer 101

HOCM: pathopneumonic A person who has syncope during exertion is more likely to have an obstruction to blood flow (aortic stenosis or hypertrophic cardiomyopathy) or ventricular tachycardia as a cause. On the other hand, syncope after completion of exercise is more likely of reflex origin, such as the common faint. https://www.uptodate.com/contents/syncope-fainting-beyond-the-basics#:~:text=A%20person%20who%20has%20syncope,such%20as%20the%20common%20faint

Answer 102

Sx and exacerbations FEV1 GOLD ABE assessment tool

Answer 103

d) Creatinine - Originally devised to predict outcomes in Cirrhotic patients undergoing portosystemic Surgery - Assess perioperative risk for patients with liver disease who undergo hepatic or non-hepatic surgery - Factors include: o Encepahlopathy § None +1 § Mild to moerate + 2 § Severe +3 o Ascites § None +1 § Mild to moderate (diuretic responsive) +2 § Severe (diuretic refractory) +3 o Bilirubin § <2 mg/dl +1 § 2-3mg/dl +2 § >3 mg/dl +3 o Albumin § >3.5g/dl +1 § 2.8-3.5g/dl +2 § <2.8g/dl +3 o INR § <1.7 +1 § 1.7-2.3 +2 § >2.3 +3 - Class A 5-6 points o 1-5yr survival rate 95% - Class B 7-9 points o 1-5 year survival rate 75% - Class C 10-15 points 1-5 yr survival rate 50% Original study Mortality rates in patients who undergo abdominal surgeries: - Class A 10% - Class B 82% - Class C 82% Newer Study mortality rates after surgery: - Class A 2% - Class B 12% - Class C 12% Drawbacks: - Subjective measurement of: o ascites o encephalopathy - Does not consider o Pre-op infection o Aetiology of cirrhosis o Surgery type

Answer 104

B. 29 PaCO2= 1.5 x 14 + 8 PaCO2= 21 + 8 PaCO2= 29 Winter’s formula: expected PaCO2 = [1.5 x (serum HCO3)] + [8±2] if PaCO2 lower, there is a concomitant primary respiratory alkalosis if PaCO2 higher, there is a concomitant primary respiratory acidosis

Answer 105

d) Pulmonary hypertension Normal spirometry + low DLCO Asthma: obstructive pattern and normal DLCO Obesity: restrictive pattern and normal DLCO Sarcoid: restrictive pattern and low DLCO

Answer 106

Give 3mg of Vitamin K and re-check on day of surgery proceed if INR <1.5 on DOS

Answer 107

d) Fixed upper Airway obstruction Fixed upper airway obstruction (can be intrathoracic or extrathoracic): flow limitation and flattening are noted in both the inspiratory and expiratory limbs of the flow-volume loop.

Answer 108

c. 9 AHA guidelines 12 Months But 12 weeks minimum Although the evidence between surgical timing and stroke risk is limited to only these 2 studies, we suggest that elective noncardiac surgery be deferred at least 6 months after a prior stroke, and possibly as long as 9 months to reduce the risk of perioperative stroke in patients undergoing noncardiac surgery. Alternatively, patients who stand to gain significant improvements in quality of life with elective surgery may consider waiting only 6 months after a prior stroke REPEAT

Answer 109

a. 35 Major updates (2022) to 1991 National Institutes of Health guidelines for bariatric surgery Metabolic and bariatric surgery (MBS) is recommended for individuals with a body mass index (BMI) 35 kg/m2 , regardless of presence, absence, or severity of co-morbidities. MBS should be considered for individuals with metabolic disease and BMI of 30-34.9 kg/m2 BMI thresholds should be adjusted in the Asian population such that a BMI 25 kg/m2 suggests clinical obesity, and individuals with BMI 27.5 kg/m2 should be offered MBS. Long-term results of MBS consistently demonstrate safety and efficacy. Appropriately selected children and adolescents should be considered for MBS. https://www.soard.org/article/S1550-7289(22)00641-4/fulltext#:~:text=The%201991%20NIH%20Consensus%20Statement,surgery%20that%20is%20applied%20universally.

Answer 110

Hypoplastic mandible (micrognathia) – difficult intubation § Pierre Robin sequence § Treacher Collins § Hemifacial microsomia (Goldenhar syndrome) Midface hypoplasia – difficult bag-mask ventilation § Apert syndrome § Crouzon syndrome § Pfeiffer syndrome § Saethre-Chotzen syndrome Macroglossia – difficult bag-mask ventilation AND difficult intubation § Hurler’s/Hunter’s syndrome (mucopolysaccharidoses) § Beckwith-Wiedemann syndrome § Down’s syndrome https://www.frca.co.uk/Documents/250%20The%20Difficult%20Paediatric%20Ai Mucopolysaccharidoses, Down syndrome, muscular dystrophies, and other neurologic disorders have been associated with obstructive sleep apnea Prevalence of OSAS. Genetic Disorder Prevalence of OSAS Neuromuscular diseases 69.2% Prader–Willi syndrome 94.7% Arnold–Chiari syndrome 80% Achondroplasia 100% Crouzon syndrome 100% https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156845/ | https://www.frca.co.uk/Documents/250%20The%20Difficult%20Paediatric%20Ai

Answer 111

Acromegaly IGF-2 is consistently elevated GH should be suppressed by glucose load in healthy pt. The continued elevation of GH despite glucose is suggestive of acromegaly

Answer 112

400mls of clear fluids pre op Safe upper limit - definitely has not not been identified and will vary from patient to patient. Clear fluids Water / CHO rich fluids / pulp free fruit juice / clear cordial / black tea and coffee

Answer 113

a. Proceed with lobectomy or pneumonectomy FEV1 surgical suitability: - >80% or >2l pneumonectomy ○ no further testing required - >80% or >1.5l lobectomy ○ no further testing required - <80% or <2l for pneumonectomy ○ -> calculate ppoFEV1 - <80% or <1.5l for lobectomy ○ -> perform DLCO and express as % of predicted DLCO ○ Saturations on air - ppoFEV1 < 40% and DLCO <40% = High Risk - ppoFEV1 >40% and DLCO >40% and SaO2 >90% = Average risk (no further testing)

Answer 114

b) Diaphragm

Answer 115

b) Myasthenia Gravis

Answer 116

b. Rocuronium 1.2mg/kg Cis not appropriate for intubation Sux with K 6.3 is risky. (I've never heard of reduced dose)

Answer 117

d. Ferritin ANZCA blue book: ACD caused primarily by inflammation Mechanism: 1. Iron - Inflammation reduces Iron availabilty as a protective mechanism whereby Iron is sequestered and stored in macrophages to limit availability to microbial pathogens - Hepcidin expression is increased, this prevents the release of Iron by reticuloendothelial system resulting in "functional iron deficiency" with reduced tissue availability of iron, despite apparently normal total body iron stores. (hence increased Ferritin) 2. Response to erythropoietin - mechanism not clear suspect blunting of response to erythropoietin 3. Therapeutic agents chemotherapies that impair bone marrow response to erythropoiesis 65% of patients with lung and gynae cancer treated with platinum based drug develop anaemia RCPA advice on interpretation of Soluble Transferrin Receptor: Soluble transferrin receptor levels in plasma are elevated if there is increased iron demand due to Iron deficiency, increased erythropoiesis (eg, Haemolysis) or dyserythropoiesis (eg, Megaloblastic anaemia), regardless of other, coexistent states. Thus, it can be used to demonstrate iron deficiency in patients who also have an acute phase response and it can distinguish Iron deficiency from the Anaemia of chronic disease. Patients with an acute phase response have reduced plasma iron and transferrin with elevation of Ferritin, making these usual indicators unreliable.

Answer 118

b. Myaesthenia gravis | ED95 is 0.8mg/kg in a MG patient

Answer 119

b) Variable extra-thoracic obstruction

Answer 120

b) flaccid paralysis Guillain–Barré syndrome (GBS) is an inflammatory disease of the PNS and is the most common cause of acute flaccid paralysis

Answer 121

Repeat c) Breast milk 3 hours, clear fluids 1 hour to max 3ml/kg Infants <6 months having elective procedure * 4 hours for formula * 3 hours for breast milk * 1 hour for clear fluids (≤3 ml/kg/hr) Children > 6 months having elective procedure * 6 hours for limited solid food or formula * 4 hours for breast milk * 1 hour for clear fluids (≤ 3ml/kg/hr)

Answer 122

multiple sclerosis. https://academic.oup.com/bjaed/article/11/4/119/266998 Anaesthetic considerations. - Local anaesthetics may exacerbate symptoms due to the increased sensitivity of demyelinated axons to local anaesthetic toxicity. - Non-depolarizing neuromuscular blocking agents may be used in normal doses. Caution should be exercised when using depolarizing neuromuscular blocking agents if the patient is debilitated. - Temperature maintenance is important as symptoms can deteriorate with an increase in temperature, as demyelinated axons are also more sensitive to heat.

Answer 123

a) 100-200 2012 BERLIN DEFINITION OF ARDS ARDS is an acute diffuse, inflammatory lung injury, leading to increased pulmonary vascular permeability, increased lung weight, and loss of aerated lung tissue…[with] hypoxemia and bilateral radiographic opacities, associated with increased venous admixture, increased physiological dead space and decreased lung compliance. Key components - acute, meaning onset over 1 week or less - bilateral opacities consistent with pulmonary edema must be present and may be detected on CT or chest radiograph - PF ratio <300mmHg with a minimum of 5 cmH20 PEEP (or CPAP) - “must not be fully explained by cardiac failure or fluid overload,” in the physician’s best estimation using available information — an “objective assessment“ (e.g. echocardiogram) should be performed in most cases if there is no clear cause such as trauma or sepsis. Severity - ARDS is categorized as being mild, moderate, or severe:

Answer 124

Phenoxybenzamine UpToDate Phenoxybenzamine is the preferred drug for preoperative preparation to control blood pressure and arrhythmia in most centers in the United States. It is an irreversible, long-acting, nonspecific alpha-adrenergic blocking agent. With their more favorable side-effect profiles and lower financial cost, selective alpha-1-adrenergic blocking agents (eg, prazosin, t erazosin, or d oxazosin) are utilized in many centers or are preferred to phenoxybenzamine when long-term pharmacologic treatment is indicated (eg, for metastatic pheochromocytoma).

Answer 125

d. 65 to 85 per hundred 85% of australians are CMV positive by the age of 40 https://www.blood.gov.au/system/files/documents/cmv-blood-components.pdf

Answer 126

A. Digitalis toxicity Miller’s The ECG made easy http://lifeinthefastlane.com/ecg-library/pmi/ Normal Q waves - Due to depolarisation of the interventricular septum from left to right - Seen in the left-sided leads (I, aVL, V5, V6) Pathological Q waves - > 1 mm depth - > 1 mm (= 40 ms) across Digoxin ECG changes - Therapeutic: prolonged PR interval (AV nodal delay), shortened QTC intervals (rapid ventricular repolarisation), ST depression (↓ slope of phase 3), T wave inversion - Toxic: atrial or ventricular arrhythmias (↑ automaticity), prolonged PR interval → heart block, SA node inhibition → sinus arrest - Atrial tachycardia with block = most common arrhythmia attributed to digoxin toxicity - VF = most frequent cause of death - QRS = normal! Q waves in MI - Occur with transmural infarctions, and are less likely with subendocardial infarctions - Develops days after the onset of AMI, and is usually permanent - Indicates the part of the heart that has been damaged LBBB ECG changes - Wide QRS - Wide QS complex in lead V1 - Wide R wave in lead V6 with slight notching at the peak and TWI - The axis is highly variable: can be normal or deviated to the left or right Wolff-Parkinson-White syndrome - Due to the presence of an accessory bundle between the atrium and ventricle, which has no AV node to delay conduction - Short PR interval - Early slurred upstroke of the QRS complex due to delta wave

Answer 127

a) Closing capacity see graph in Millers

Answer 128

age Domains: 1. Cognition 2. General health status 3. Functional independance 4. social support 5. Medication use 6. Nutrition 7. Mood ?interpreted as mental illness in stem? 8. Continence 9. Functional performance Scoring 0-5= Not frail 6-7= Vulnerable 8-9= Mild Frailty 10-11= Moderate Frailty 12-17= Severe Frailty Easy way to remember is CONFUSION Cognition Overall Health Nutrition Function performance Urine incontinence Social support Independence Oral Meds Nightmares

Answer 129

a) Variable intra-thoracic obstruction Dynamic (or variable, nonfixed) intrathoracic obstruction: flow limitation and flattening are noted on the expiratory limb of the loop.

Answer 130

b) severe dermatographia

Answer 131

b) severe dermatographia

Answer 132

Anaemia of chronic inflamation with iron deficiciency

Answer 133

Fluoxetine

Answer 134

) Hypertension Talley & O'Connor CVS Exam: S3: Physiological in pregnancy; sign of LV failure; AR & MR S4: Never physiological, most often due to systemic hypertension Atrial gallop - stiff LV - hypertrophy or ischaemic ventricle Source CV phys

Answer 135

Emboli Blue book repeat

Answer 136

albumin ALBUMIN AND PHOSPHATE the normal anion gap depends on serum phosphate and serum albumin the normal AG = 0.2 x [albumin] (g/L) + 1.5 x [phosphate] (mmol/L) albumin is the major unmeasured anion and contributes almost the whole of the value of the anion gap. every 1g/L decrease in albumin will decrease anion gap by 0.25 mmoles a normally high anion gap acidosis in a patient with hypoalbuminaemia may appear as a normal anion gap acidosis. this is particularly relevant in ICU patients where lower albumin levels are common Effects of albumin: Anion gap may be underesitmated in hypoalbuminaemia, because if albumin decreased by 1g/L then the anion gap decreases by 0.25 mmol To overcome the effects of the hypoalbuminaemia on the AG, the corrected AG can be used which is AG + (0.25 X (40-albumin) expressed in g/L

Answer 137

c) non-tunneled CVL UTD: In a systematic review that included 200 studies, the risk of catheter-related blood stream infection per 1000 catheter-days and varied by types of intravascular catheter were as follows [38]: ●Peripherally inserted central catheters (PICCs) – 1.1 (95% CI 0.9-1.3) ●Cuffed and tunneled central venous catheters – 1.6 (95% CI 1.5-1.7) ●Noncuffed central venous catheters *Nonmedicated and tunneled – 1.7 (95% CI 1.2-2.3) *Nonmedicated and nontunneled – 2.7 (95% CI 2.6-2.9) However, there was no adjustment for severity of illness. Therefore, a particular type of catheter could be associated with an increased risk of infection if it was preferentially used in more severely ill or vulnerable patients.

Answer 138

e) hypoglycaemia

Answer 139

d) No difference Repeat Conclusions In patients undergoing mechanical ventilation, the rate of survival at 90 days associated with the use of an energy-dense formulation for enteral delivery of nutrition was not higher than that with routine enteral nutrition. (Funded by National Health and Medical Research Institute of Australia and the Health Research Council of New Zealand; TARGET ClinicalTrials.gov number, NCT02306746. opens in new tab.) https://www.nejm.org/doi/full/10.1056/NEJMoa1811687

Answer 140

ASA 3 Source: ASA Classification https://www.asahq.org/standards-and-guidelines/asa-physical-status-classification-system

Answer 141

c. Low potassium diet (high K diet - dec HTN)

Answer 142

neurological damage due to methionine deficit

Answer 143

pancreatic fistula -> should cause NAGMA HAGMA: Lactate Toxins Ketones Renal failure NAGMA Chloride Addison's, adrenal insuffiency, acetazolamide GI loss (pancreatic fistula) Extra: RTA Anion gap: - Anion Gap = Na+ – (Cl- + HCO3-) - The Anion Gap (AG) is a derived variable primarily used for the evaluation of metabolic acidosis to determine the presence of unmeasured anions - The normal anion gap is assumed to be 12, and the normal HCO3 is assumed to be 24 Delta ratio: - can check delta ratio in the presence of a high anion gap metabolic acidosis (HAGMA) to determine if it is a ‘pure’ HAGMA or if there is coexistant normal anion gap metabolic acidosis (NAGMA) or metabolic alkalosis.

Answer 144

Postpone 3 months and give oral iron

Answer 145

e) Normal Normal flow-volume loop: the expiratory portion of the flow-volume curve is characterized by a rapid rise to the peak flow rate, followed by a nearly linear fall in flow. The inspiratory curve is a relatively symmetrical, saddle-shaped curve.

Answer 146

c. Decreased platelet function

Answer 147

strained broth ANZCA PS07: "Clear fluids are regarded as water, carbohydrate rich fluids, specifically developed for perioperative use, pulp free fruit juice, clear cordial, black tea and coffee. It excludes fluids containing particulate matter, soluble fibre, milk-based drinks and jelly"

Answer 148

d) Sarcoidosis Pulmonary hypertension: Normal spirometry + low DLCO Asthma: obstructive pattern and normal DLCO Obesity: restrictive pattern and normal DLCO Sarcoid: restrictive pattern and low DLCO

Answer 149

I:E ration 1:3 BJA Lung-protective ventilation for the surgical patient: international expert panel-based consensus recommendations: An expert consensus was reached for 22 recommendations and four statements. The following are the highlights: (i) a dedicated score should be used for preoperative pulmonary risk evaluation; and (ii) an individualised mechanical ventilation may improve the mechanics of breathing and respiratory function, and prevent PPCs. The ventilator should initially be set to a tidal volume of 6–8 ml kg−1 predicted body weight and positive end-expiratory pressure (PEEP) 5 cm H2O. PEEP should be individualised thereafter. When recruitment manoeuvres are performed, the lowest effective pressure and shortest effective time or fewest number of breaths should be used. Inspiratory/expiratory ratio: Several studies have compared prolonged inspiratory-to-expiratory (I:E) ratios to the 1:2 ratio commonly used during mechanical ventilation. An I:E ratio of 1:1, which has been characterised as providing a ‘balanced stress to time product’, was associated with attenuation of lung damage. Prolonged I:E ratio increases mean airway pressure and concomitantly reduces peak airway pressure. Studies using prolonged inspiratory times have described beneficial effects, including increased CRS and PaO2, lower alveolar–arterial gradient, and reduced inflammatory markers. Given the lack of evidence for a clear benefit of a specific I:E ratio, no recommendation was offered by the panel. However, the panel noted that optimisation of inspiratory time for individual patients can be achieved by monitoring parameters, such as oxygenation, CRS, and ΔP. Intraoperative FIO2 Increased FIO2 during mechanical ventilation is administered to prevent or correct hypoxaemia, but may result in hyperoxia. The negative effects of hyperoxia are not clear, but it has been suggested that it may increase oxidative stress, peripheral vascular and coronary artery vasoconstriction, decrease cardiac output, increase resorption atelectasis, and increase the rate of PPCs. Recommendations for optimal use of oxygen and current evidence regarding the association between hyperoxaemia and clinically relevant outcomes during intraoperative mechanical ventilation are lacking. Few studies have revealed a protective effect of hyperoxaemia, some report an association with mortality, whilst others show no association with clinically relevant outcomes. Therefore, in the absence of evidence, the most prudent course of action during mechanical ventilation is to maintain normoxaemia. SpO2 monitoring can assist in the detection of hypoxaemia, but during oxygen therapy SpO2 cannot detect hyperoxia. Whilst SpO2 monitoring reduces the incidence of hypoxaemia, it does not improve the overall patient outcomes and does not reduce morbidity and mortality. Therefore, once the airway is secured, FIO2 should be set to ≤0.4 with the goal of using the lowest possible FIO2 to achieve normoxia (or SpO2 ≥94%) Unnecessarily high FIO2 should be avoided. Administering lower FIO2 will not only decrease the risk of hyperoxia, but will also reduce the masking effect of oxygen therapy and allow for earlier diagnosis of gas-exchange impairment.

Answer 150

30ml/cm H2O 600/32-8+4 = 30 Static lung compliance (Cstat), mL/cm H2O = TV / (Plateau pressure (Pplat) – TotalPEEP) remembered parameters included PEEP = 8 and autop PEEP = 4 if actual answer states TotalPEEP= 8 then no need to add 4 to the calculation

Answer 151

b) 2 - if male CHA2DS2-VASc score ≥2 to be recommended chronic OAC (Grade 1A). - if female CHA2DS2-VASc score ≥3 to be recommended chronic OAC (Grade 1A). * non-sex risk factor also holds bearing: - For patients with CHA2DS2-VASc score of 1 in males and 2 in females based on age 65 to 74 years, we recommend chronic OAC (Grade 1A). Up to date: Our approach to deciding whether to prescribe anticoagulant therapy for patients with AF (excluding those with rheumatic mitral stenosis that is severe or clinically significant [mitral valve area ≤1.5 cm2], a bioprosthetic valve [surgical or bioprosthetic] within the first three to six months after implantation, or a mechanical heart valve) is as follows: *For a CHA2DS2-VASc score ≥2 in males or ≥3 in females, we recommend chronic OAC (Grade 1A). *For a CHA2DS2-VASc score of 1 in males and 2 in females: -For patients with CHA2DS2-VASc score of 1 in males and 2 in females based on age 65 to 74 years, we recommend chronic OAC (Grade 1A). Age 65 to 74 years is a stronger risk factor than the other factors conferring one CHA2DS2-VASc score point. -For patients with other risk factors, the decision to anticoagulate is based upon the specific nonsex risk factor and the burden of AF. For patients with very low burden of AF (eg, AF that is well documented as limited to an isolated episode that may have been due to a reversible cause such as recent surgery, heavy alcohol ingestion, or sleep deprivation), it may be reasonable to forgo chronic OAC and institute close surveillance for recurrent AF, although it may not be possible to reliably estimate AF burden from surveying symptoms or infrequent monitoring. The frequency and duration of AF episodes vary widely over time, and episodes are often asymptomatic. *For patients with a CHA2DS2-VASc of 0 in males or 1 in females, we suggest against OAC (Grade 2C). Patient values and preferences may impact the decision. For example, a patient who is particularly stroke averse and is not at increased risk for bleeding may reasonably choose anticoagulation, particularly if the patient is a candidate for treatment with a direct oral anticoagulant (DOAC). 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline

Answer 152

e. Obstructive w/ reduced FEV1 Mucous narrowing airways = obstructive Parenchymal damage = restrictive Obstructive PFP remains the most common pulmonary function pattern in adult CF and is associated with -decrease FEV1 & FVC/FEV1 For patients with CF, an obstructive pattern is generally seen, with a decrease in forced expiratory volume in 1 s (FEV1), and forced vital capacity (FVC) to FEV1 ratio. https://academic.oup.com/bjaed/article/11/6/204/263786

Answer 153

c. 9 AHA guidelines 12 Months But 12 weeks minimum Although the evidence between surgical timing and stroke risk is limited to only these 2 studies, we suggest that elective noncardiac surgery be deferred at least 6 months after a prior stroke, and possibly as long as 9 months to reduce the risk of perioperative stroke in patients undergoing noncardiac surgery. Alternatively, patients who stand to gain significant improvements in quality of life with elective surgery may consider waiting only 6 months after a prior stroke

Answer 154

a) R1 side chain UP TO DATE: - sensitisation to R1 side chain in cephalosporins important in determining cross reactivity with penicillins.

Answer 155

Repeat d) Sarcoidosis Normal FEV1/FVC ratio = no obstruction Low FVC = restrictive pattern Low DLCO = interstitial lung disease Asthma and emphysema would have obstructive pattern. Myasthenia gravis would have normal DLCO Pulmonary HTN would have normal spirometry and low DLCO.

Answer 156

Answer: b. rocuronium anaphylaxis NB RadioAllergoabsorbentSpecificTesting is a serum test for specific IgE antibodies RAST morphine is both more sensitive and more specific than the RAST for individual NMBDs (due to reaction with quaternary ammonium) and is being used increasingly to determine NMBDs as cause of anaphylaxis. IKR! http://www.anzaag.com/anaphylaxis-management/testing-guidelines.pdf

Answer 157

Answer: d. Rocuronium BJA Anaphylaxis to neuromuscular blocking drugs: incidence and cross-reactivity in Western Australia from 2002 to 2011 https://academic.oup.com/bja/article/110/6/981/245571 Rocuronium has a higher rate of IgE-mediated anaphylaxis compared with vecuronium, a result that is statistically significant and clinically important. Cisatracurium had the lowest rate of cross-reactivity in patients who had previously suffered anaphylaxis to rocuronium or vecuronium. Anaphylaxis rates (highest to lowest) Primary anaphylaxis: rocuronium > atracurium > vecuronium > pancuronium = cisatracurium Cross-reactivity: suxamethonium > rocuronium > vecuronium > pancuronium > atracurium > cisatracurium

Answer 158

b. von willebrand's disease - autosomal dominant inheritance - may have normal or prolonged APTT, PT is normal *Haem A: X-linked recessive disorder; would expect prolonged aPTT, and normal PT *Haem B: X-linked recessive disorder; would expect normal aPTT and normal PT REPEAT | vWD can have prolonged APTT or normal APTT. Haemophilias are X-linked

Answer 159

5d ANZCA - CrCl >80 (3D) 80-50 (4D) <50 (5D)

Answer 160

Taking > 1 month https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/anae.14963 Daily doses of prednisolone of 5 mg or greater in adults and 10–15 mg.m−2 hydrocortisone equivalent or greater in children may result in hypothalamo–pituitary–adrenal axis suppression if administered for 1 month or more by oral, inhaled, intranasal, intra-articular or topical routes; this chronic administration of glucocorticoids is the most common cause of secondary adrenal suppression, sometimes referred to as tertiary adrenal insufficiency All children who have known glucocorticoid deficiency (primary or secondary), or who are at risk of glucocorticoid deficiency (on significant exogenous dose of glucocorticoid >10–15 mg.m-2 per day) 38, should receive an i.v. dose of hydrocortisone at induction (2 mg.kg−1 for minor or major surgery under general anaesthesia).

Answer 161

c) FEV1 43% In pulmonary function testing, a post-bronchodilator FEV1/FVC ratio of <0.70 is commonly considered diagnostic for COPD. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) system categorises airflow limitation into stages. In patients with FEV1/FVC <0.70: GOLD 1 - mild: FEV1 ≥80% predicted GOLD 2 - moderate: 50% ≤ FEV1 <80% predicted GOLD 3 - severe: 30% ≤ FEV1 <50% predicted GOLD 4 - very severe: FEV1 <30% predicted.

Answer 162

b) Alcoholic liver disease - AST>ALT In hepatitis and paracetamol toxicity would expect ALT>AST. In cholecystitis, would expect a cholestatic picture with raised conjugated bilirubin and raised GGT/ALP. LITFL: Overall analysis of Liver Function Tests (LFT) Transaminitis: Aminotransferases (AST, ALT) - Generally associated with hepatocellular damage - Generally not associated with cholestasis Ratio of AST and ALT can be useful in differential ALT is more specific for liver damage than AST AST: ALT =1 -> Associated with ischaemia (CCF and ischaemic necrosis and hepatitis) AST: ALT >2.5 -> Associated with Alcoholic hepatitis -> Alcohol induced deficiency of pyridoxal phosphate AST: ALT <1 -> High rise in ALT specific for Hepatocellular damage -> Paracetamol OD with hepatocellular necrosis -> Viral hepatitis, ischaemic necrosis, toxic hepatitis -> Elevation with cholestasis (ALP, GGT) ALP – primarily associated with cholestasis and malignant hepatic infiltration Marker of rapid bone turnover and extensive bony metastasis GGT – sensitive to alcohol ingestion Marker of hepatocellular damage but non-specific Sharpest rise associated with biliary and hepatic obstruction

Answer 163

c) Continuation leads to increased risk of major bleeding Aspirin in patients undergoing non cardiac surgery https://www.nejm.org/doi/full/10.1056/nejmoa1401105 Conclusions Administration of aspirin before surgery and throughout the early postsurgical period had no significant effect on the rate of a composite of death or nonfatal myocardial infarction but increased the risk of major bleeding. (Funded by the Canadian Institutes of Health Research and others; POISE-2 ClinicalTrials.gov number

Answer 164

Creatinine Model for End-stage Liver Disease - Estimates disease severity and survival in patients with Liver Disease - Objective assessment - Score from 6-40 - Validated across a number of liver diseases and surgeries - MELD score is used as a method of allocation of organs to estimate survival MELD uses the following parameters: - Bilirubin - INR - Creatinine - [Hyponatraemia] ○ Part of the MELD-Na score update in 2016 ○ Sodium (Na) Values < 125 are set to 125 and values >137 are set to 137 4 MELD levels are: - >/=25 (gravely ill) - 24-19 - 18-11 - 15 should avoid elective surgery Calculation: MELD = 3.8*loge(serum bilirubin [mg/dL]) + 11.2*loge(INR) + 9.6*loge(serum creatinine [mg/dL]) + 6.4 MELD-Na = MELD + 1.32 * (137-Na) - [0.033*MELD * (137-Na)]

Answer 165

b) 90 PAO2: 0.4 (760 - 47) - 48/0.8 = 285 - 60 = 225mmHg 225 - 135 = 90mmHg.

Answer 166

Hereditary spherocytosis. Auto-haemolytic, intraplenic haemolysis. High reticulocyte count (6-20%) (normal range 0.5-2%)

Answer 167

renal tubular acidosis-> NAGMA HAGMA: Causes CATMUDPILES - CO/CN - Alcoholic ketoacidosis/ starvation ketoacidosis - Toluene (paint thinners) - Metformin/Methanol - Uraemia - DKA - Pyroglutamic Acidosis/paracetamol/ phenformin/propylene glycol/paraldehyde - Iron/ Isoniazid - Ethylene glycol (anti-freeze) - Salicylic Acid NAGMA: Causes CAGE: - Chloride - Acetazolamide and Addison's - GI causes (vomiting, diarrhoea, fistula) Extras: RTA

Answer 168

Uncertain SIADH: 1. hypotonic hyponatraemia 2. urine osmolality > plasma osmolality (<275mOsm/kg) (i.e. concentrated urine despite hypotonic blood) 3. urinary Na+ > 20mmol/L 4. normal renal, hepatic, cardiac, pituitary, adrenal and thyroid function 5. euvolaemia (absence of hypotension, hypovolaemia, and oedema) 6. correction by water restriction Addison's Hypo natraemia HYPER kalaemia Hypo glycaemia Acidosis Diuretics Hypo natraemia Hypo kalaemia High urinary Na and K https://www.derangedphysiology.com/files/Electrolyte%20Disturbance.pdf JAMA article on hyponatraemia https://emergencymed.org.il/wp-content/uploads/2022/08/jama_adrogu_2022_rv_220011_1657919726.49616.pdf

Answer 169

b. Unstable angina UTD: Unstable angina (UA) and acute non-ST elevation myocardial infarction (NSTEMI) differ primarily in whether the ischemia is severe enough to cause sufficient myocardial damage to release detectable quantities of a marker of myocardial injury (troponins): ●UA is considered to be present in patients with ischemic symptoms suggestive of an ACS and no elevation in troponins, with or without electrocardiogram changes indicative of ischemia (eg, ST segment depression or transient elevation or new T wave inversion). ●NSTEMI is considered to be present in patients having the same manifestations as those in UA, but in whom an elevation in troponins is present. MINS: Myocardial injury after non-cardiac surgery (up to 30 days post-op): 1. Elevated postop troponin 2. Resulting from myocardial ischaemia (i.e. no evidence of a non-ischaemic aetiology), not requiring an ischaemic feature (i.e. no chest pain, no ECG change) VISION studies (Vascular Events in Noncardiac Surgery Patients Cohort Evaluation) demonstrated that severity of MINS strongly associated with 30-day mortality after NCS. hs-cTnT <20ng/L ~ 0.5% 30 day mortality 20-64ng/L ~3% 30 day mortality 65-999 ng/L ~9% 30 day mortality >1000ng/L ~30% 30 day mortality Whilst VISION trial identified MINS in at risk patients, the question now becomes what interventions are available to prevent this complication?

Answer 170

c) Lower airway obstruction Peripheral or lower airways obstruction: expiratory limb demonstrates concave upward, also called "scooped-out" or "coved" pattern.

Answer 171

E. 100 mcg/L ?? < 30mcg/L < 100mcg/L IF CRP > 5 and/or Transferrin saturation < 20 https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.13773#:~:text=Recommendations%20for%20best%20clinical%20practice,-Physicians%20should%20consider&text=The%20presence%20of%20anaemia%20should,identification%20of%20absolute%20iron%20deficiency.

Answer 172

Tracheal stenosis

Answer 173

b) No difference NEJM: Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis Among patients with septic shock who had severe acute kidney injury, there was no significant difference in overall mortality at 90 days between patients who were assigned to an early strategy for the initiation of renal-replacement therapy and those who were assigned to a delayed strategy.

Answer 174

b. 1 or more RF In this iteration of the PONV guideline, one of the major changes is that we now recommend the use of multimodal prophylaxis in patients with one or more risk factors. This decision was made due to the concern over inadequate prophylaxis as well as the availability of antiemetic safety data.

Answer 175

b. Gelofusin Gelatin

Answer 176

repeat a) Less transfusion, same thrombosis ●A 2019 meta-analysis of randomized trials comparing preoperative administration of EPO versus placebo (32 trials; 4750 patients, mostly orthopedic and cardiac surgery) found reduced blood transfusions in the EPO groups. Decreased blood transfusions were seen in the entire population (RR 0.59, 95% CI 0.47-0.73; 28 trials), as well as the subgroups undergoing cardiac surgery (RR 0.55, 95% CI 0.47-0.73; nine trials) and major orthopedic surgery (RR 0.36, 95% CI 0.28-0.46; five trials). In addition, the EPO group had increased hemoglobin levels. There was no increase in the incidence of thromboembolic events with EPO.

Answer 177

a) over-expansion The first graphic (loop a) shows the pattern of a typical pressure-volume loop, which rises in a counterclockwise direction until forming a complete loop. It also displays inflection points, which display rapid changes to the slope of the limb. The lower inflection point (LIP) occurs due to the opening of collapsed alveoli, resulting in a sharp increase in volume. The upper inflection point (UIP) occurs near the end of inspiration when more pressure leads to only a minimal increase in volume. The second graphic (loop b) displays how overdistension and hysteresis appear on a pressure-volume loop. Overdistention occurs when the lungs receive too much volume or pressure and can result in injury. Hysteresis refers to lung tissue that behaves differently on inspiration and expiration. In other words, it takes more energy for the lungs to inflate than it does to deflate. Therefore, hysteresis on a pressure-volume loop refers to the space between the inspiratory and expiratory limbs. When the patient’s lung compliance or airway resistance changes, so will the hysteresis and, thus, the appearance of the loop. Note: A pressure-volume loop under normal conditions should resemble the shape of a football (American). A curve with a flat appearance indicates decreased lung compliance. A steep curve, on the other hand, indicates increased lung compliance. A wide curve indicates increased airway resistance, whereas the opposite is true if the loop appears more narrow. https://www.respiratorytherapyzone.com/ventilator-waveforms/#:~:text=Note%3A%20A%20pressure%2Dvolume%20loop,hand%2C%20indicates%20increased%20lung%20compliance.

Answer 178

b) O2 consumption when sitting One metabolic equivalent (MET) is defined as the amount of oxygen consumed while sitting at rest and is equal to 3.5 ml O2 per kg body weight x min.

Answer 179

Life threatening organ dysfunction caused by a dysregulated host response to infection

Answer 180

Category GFR ml/min/1.73 m2 Terms G1 ≥90 Normal or high G2 60-89 Mildly decreased* G3a 45-59 Mildly to moderately decreased G3b 30-44 Moderately to severely decreased G4 15-29 Severely decreased G5 <15 Kidney failure Assign Albuminuria category as follows: Albuminuria categories in CKD Category ACR (mg/g) Terms A1 <30 Normal to mildly increased A2 30-300 Moderately increased* A3 >300 Severely increased** Abbreviations: ACR, albumin-to-creatinine ratio; CKD, chronic kidney disease. *Relative to young adult level. **Including nephrotic syndrome (albumin excretion ACR >2220 mg/g) **Collectively referred to as “CGA Staging” REPEAT

Answer 181

ANSWER: d. Ferritin <100mcg/L Serum ferritin level < 30 μg.l−1 is the most sensitive and specific test used for the identification of absolute iron deficiency. However, in the presence of inflammation (C-reactive protein > 5 mg.l−1) and/or transferrin saturation < 20%, a serum ferritin level < 100 μg.l−1 is indicative of iron deficiency. International consensus statement on peri-operative management of anaemia and iron deficiency https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.13773#:~:text=Recommendations%20for%20best%20clinical%20practice,-Physicians%20should%20consider&text=Serum%20ferritin%20level%20%3C%2030%20%CE%BCg,serum%20ferritin%20level%20%3C%20100%20%CE%BCg.

Answer 182

c Oral iron and defer or d give IV iron - most assume its IV iron and proceed but - Assuming IDA and raised CRP then iron therapy but 'deferable' surgery? then oral and come again in 6 weeks if not deferrable then IV iron - surely a revision THR is deferable?? - If give IV iron and defer was an option I would choose that one, it would allow assessment of inflammatory process and to confirm Hb and ferritin are at an acceptable level International consensus statement on the peri-operative management of anaemia and iron deficiency https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.13773 However, many patients will not respond to oral iron, especially those with functional iron deficiency and chronic illness or infection and those with ongoing blood loss 15, 25. Others will not tolerate oral iron due to gastro-intestinal side-effects. Once oral iron has been commenced, the Hb should be measured again, at least 4 weeks before surgery. In the absence of an increased Hb or if the patient is intolerant, i.v. iron is the preferred replacement route. If surgery is planned in less than 6 weeks time, i.v. iron may also be the most effective option.

Answer 183

d. Asthma What are the causes of an elevated DL CO ? The causes of an elevated DLCO are numerous, but is most commonly caused by asthma and obesity (increased pulmonary blood flow). Pulmonary hemorrhage is an additional important cause. https://www.atsjournals.org/doi/pdf/10.1513/AnnalsATS.201605-355CC

Answer 184

b) Pulmonary hypertension Up to date: Overview of pulmonary function testing in adults Diffusing capacity — Measurement of the single-breath diffusing capacity for carbon monoxide (DLCO; also known as transfer factor or TLCO) is quick, safe, and useful in the evaluation of restrictive and obstructive lung disease, as well as pulmonary vascular disease. The technique and interpretation are discussed separately. In the setting of restrictive disease, the diffusing capacity helps distinguish between intrinsic lung disease, in which DLCO is usually reduced, and other causes of restriction, in which DLCO is usually normal. In the setting of obstructive disease, the DLCO helps distinguish between emphysema, in which it is usually reduced, and other causes of chronic airway obstruction, like asthma or chronic bronchitis, where it is usually normal. The DLCO is also used in the assessment of pulmonary vascular disease (eg, thromboembolic disease, pulmonary hypertension), which typically causes a reduction in DLCO in the absence of significant restriction or obstruction

Answer 185

a. Reduced myoglobinuria weird double negative question, answers don't quite fit grammatically, however - There is NOT reduced myoglobinuria with AIR compared to MH (both have myoglobinuria) - There IS less increase in ETCO2 - There IS less muscle rigidity Anesthesia-induced rhabdomyolysis or malignant hyperthermia: is defining the crisis important? College library drop "is defining the crisis important?" from search https://onlinelibrary-wiley-com.ezproxy.anzca.edu.au/doi/full/10.1111/pan.13130?sid=worldcat.org

Answer 186

d) 6 months ANZCA PS 12 perioperative smoking https://www.anzca.edu.au/getattachment/5deb6800-e8f9-453f-b9a6-a151a9323249/PG12(POM)-Guideline-on-smoking-as-related-to-the-perioperative-period-(PS12) Effects of quitting 1 day - Reduced HbCO3-> increased O2 content - Reduced nicotine/ SNS stimulation 3 weeks - Increased wound healing 6-8 weeks - Reduced sputum volume - Increased lung function 6 months - Increased immune function

Answer 187

C) AMI The association between OSA and perioperative mortality is unclear [19], with various studies showing increased [12,23] or comparable [14] mortality. While decreased mortality [7,18,43] has been reported in retrospective studies, this may be due to unrecognized or undiagnosed OSA in the control or non-OSA groups, and/or the possibility that patients with diagnosed OSA received monitoring and treatment of their OSA. SOBA 2015: Severe OSA occurs in 10–20% of patients with BMI > 35 kg.m2 and is often undiagnosed. Overall, a diagnosis of OSA is associated with a greater than doubling of the incidence of postoperative desaturation, respiratory failure, postoperative cardiac events and ICU admission [16]. The presence of multiple and prolonged oxygen desaturations increases the sensitivity to opioid-induced respiratory depression [17]. However, if identified pre-operatively and treated appropriately with continuous positive airway pressure (CPAP), the risk of complications is much reduced [18]. Obesity has no influence on the rate of unanticipated admission, postoperative complications, readmission or other unplanned contact with health professionals after home discharge.

Answer 188

HCO3- is derived from pCO2 and pH Base excess is derived from pH SaO2 is derived from oxyHb and Hb Source LITFL

Answer 189

b) IgE mediated (i.e. anaphylaxis) rocuronium allergy Morphine RAST is most sensitive (88%) and specific (100%) test for NMBD as cause of anaphylaxis (quaternary ammonium epitope)

Answer 190

Previous Q (23.1) with different options. ANSWER C (INR)

Answer 191

b) Pain score Aldrete score, which includes five elements (activity, respiration, circulation, consciousness, oxygen saturation) [16]. The original scoring system was developed before the invention of pulse oximetry and used the patient's colouration as a surrogate marker of their oxygenation status. A modified Aldrete scoring system was described in 1995 which replaces the assessment of skin colouration with the use of pulse oximetry to measure SpO2. The Modified Aldrete system includes five additional elements that are particularly useful during the Phase II recovery period prior to discharge to home (dressing, pain, ambulation, feeding, urine output)

Answer 192

d) Pulmonary haemorrhage Rewording of 21.2 Question Won't increase in Myasthenia Gravis Causes of HIGH value include: Asthma Left-right intracardiac shunt polycythaemia Pulmonary haemorrhage Obesity - Dlco will increase but kco will not

Answer 193

Warm ischaemia time: - Time from treatment withdrawal to the start of cold perfusion of the donated organs - Significance is the impact on graft function - Most important phase of WIT begins when the systolic BP is < 60mmHg - This includes the waiting period from the absence of circulation to the declaration of death and the time before initiating the flow of cold perfusate through the cannula Maximum WARM Ischaemia time - Heart 30 mins - Liver 30 mins - Pancreas 30 mins - Kidney 60 mins - Lungs 90 mins Maximum COLD Ischaemia time: - Heart = 4 hrs - Lungs = 6-8hrs - Liver/Pancreas = 12hrs (DBD)/6 hrs (DCD) - Kidneys = 18hrs (DBD)/ 12 hrs (DCD)

Answer 194

24hrs Oxford handbook

Answer 195

b) O2 consumption when sitting One metabolic equivalent (MET) is defined as the amount of oxygen consumed while sitting at rest and is equal to 3.5 ml O2 per kg body weight x min.

Answer 196

Most likely answer will be related to hypophosphataemia Refeeding syndrome is a constellation of biochemical abnormalities which occurs when normal intake is resumed after a period of starvation. Its characteristic features are **low levels of phosphate, potassium, magnesium and sodium**. Its major complications include **cardiac arrhythmias, heart failure (due to hypophosphataemia), muscle weakness, rhabdomyolysis, seizures and an altered sensorium.** The major risk factors are calorie malnutrition of any cause, alcohol or drug use, low BMI (18-16) and starvation for 5-10 days. Pathophysiology With the restoration of glucose as a substrate, insulin levels rise and cause cellular uptake of these ions. **Depletion of adenosine triphosphate (ATP) and 2,3-diphosphoglyceric acid (2,3-DPG)** results in **tissue hypoxia** and **failure of cellular energy metabolism.** This may manifest as **cardiac and respiratory failure**, with **paraesthesiae** and **seizures** also reported. Thiamine deficiency may also play a part. - Exogenous sources of phosphate are inadequate to supplement the daily phosphate requirements - Intracellular phosphate stores are used to synthesise ATP (using protein and fat as fuel) - Homeostatic mechanisms maintain serum concentrations of these ions at the expense of intracellular stores Reference: https://derangedphysiology.com/main/required-reading/endocrinology-metabolism-and-nutrition/Chapter%20315/refeeding-syndrome "

Answer 197

e) stop 2 weeks before, start moclobemide and omit Moclobemide day of surgery -> probably in discussion with the patients psychiatrist Tranylcypromine, sold under the brand name Parnate among others, is a monoamine oxidase inhibitor. More specifically, tranylcypromine acts as nonselective and irreversible inhibitor of the enzyme monoamine oxidase. In the elective setting, there is some debate regarding the management of patients on MAOI. Although the risks associated with anaesthesia in those taking this group of drugs are significant, abrupt withdrawal may precipitate serious psychiatric relapse. Traditionally, irreversible MAOIs have been stopped 2 weeks before operation; however, omitting the dose of moclobemide on the day of surgery is acceptable. It has been suggested that in the elective situation, patients could be switched from an irreversible MAOI to moclobemide to avoid a prolonged period of discontinuation.

Answer 198

a) Iron transfusion Iron infusion (ferric carboxymaltose) – can cause renal wasting of phosphate resulting in severe hypophosphataemia Vitamin D deficiency and hyperparathyroidism can also cause hypophosphataemia. Vitamin D deficiency would result in low calcium whereas hyperparathyroidism would result in hypercalcaemia. Fanconi syndrome: rare defect of proximal tubule leading to decreased reabsorption -> results in hypokalaemia, hypophosphataemia, hyperchloraemic metabolic acidosis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689119/

PeriOp Flashcards

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